Effects of institutional room acoustics on speech discrimination of developmentally disabled residents and of staff.

High ambient noise levels and long reverberation times can degrade speech discrimination. An experiment examined the effects on speech discrimination of 2 acoustic factors: (a) noise level (high, 72 db; low, 65 db); and (b) reverberation times (long, 1.77 sec; short, .79 sec). Ss were 12 developmentally disabled state school residents and 12 normal staff members. Their speech discrimination abilities were tested under conditions simulating the institutional environment prior to renovations (high noise/long reverberation time) and following renovations (low noise/short reverberation time). A 3-way mixed ANOVA showed main effects of noise, reverberation time, and group. There was a Noise?×?Group interaction and a significant difference between simulated prerenovation and postrenovation conditions. (21 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Visual attention in HIV-1 infection.

27 nondemented HIV-seropositive men and 13 seronegative controls performed 2 versions of a spatial attention task that engaged either automatic or controlled attentional processing. Ss also performed a 3rd task requiring divided attention, which tested for potential deficits in attentional resources. HIV-seropositive symptomatic Ss were impaired on the automatic processing task, whereas asymptomatic Ss performed the task normally compared with controls. In contrast, no differences were observed among the 3 groups on the controlled attention task. However, both seropositive groups showed deficits on the divided attention task. These results suggest that deficits in selective attention are present early in the course of HIV-1 infection. The most prominent impairment is seen on tasks that are highly demanding of attentional resources, whereas deficits in automatic processing develop later in the disease process. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Typicality effects in attitudes toward social policies: A concept-mapping approach.

Social typicality effects occur when people apply their attitudes more consistently toward typical than toward atypical category members presumably because attitudes are directed toward the prototypic category member. Four studies tested whether individuals also apply social policy attitudes more consistently toward typical than toward atypical persons affected by the policy. Study 1 used attitude concept maps to assess how extensively individuals spontaneously reference the typical person affected by a social policy. Death penalty proponents did so more than did opponents; welfare proponents and opponents did so equally. In 3 other studies, death penalty proponents displayed greater typicality effects in sentencing "convicted murderers" than did opponents, welfare proponents and opponents displayed equal typicality effects in evaluating cases of suspected welfare fraud, and individuals whose attitude concept maps about welfare referred more to persons displayed greater typicality effects than did individuals whose maps referred more to principles. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Generalization of dissonance reduction: Decreasing prejudice through induced compliance.

Three studies involving a total of 318 White college students demonstrated that induced compliance can change socially significant attitudes and that the change generalizes to broader beliefs. Ss wrote an essay endorsing a pro-Black policy that was costly to Whites. In Exps 1 and 2, attitudes and general beliefs about Blacks became more favorable in both high- and low-choice conditions, provided publicity of the essay was high. Overall, choice and publicity had additive effects on attitude change. Some high-choice Ss wrote only semipositive (semicompliant) essays and did not change their essay attitudes. Yet their beliefs about Blacks still became more favorable. In Exp 3, racial ambivalence, but not prior attitude, predicted essay compliance. Ambivalent Ss were more likely to comply than were less ambivalent Ss. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Generation

The structure and function of the target-language generation module for KBMT-89 is described. The lexical selection module (which includes thematic-role subcategorization, a meaning distance metric, and syntactic subcategorization) is presented. We also describe the generation mapping rules, and rule interpretation in the generation of f-structures for target language utterances.     

Comprehensive assay of flavanones in citrus juices and beverages by UHPLC–ESI-MS/MS and derivatization chemistry

Flavanones, a class of flavonoids present in large amounts in fruits and vegetables, have been assayed by LC–MS/MS and derivatization chemistry using d₀/d₃-labelled derivatized internal standards obtained by simple reaction procedures which involves d₀/d₃ methoxyamine. The assay method considers 13 flavanones including aglycones, neohesperidosides, rutinosides and 3-hydroxy-3-methyl glutaryl derivatives. The strengths of the method consist in a relative short analysis time (16 min) and good repeatability and reproducibility values which are in most cases under 10% (RSD%). The accuracy values range from 95.4% to 111.3% whilst the LOQ values ranges from 0.05 to 0.29 mg/L depending on the analyte.     

Functional Chromatography Reveals Three Natural Products that Target the Same Protein with Distinct Mechanisms of Action

Access to lead compounds with defined molecular targets continues to be a barrier to the translation of natural product resources. As a solution, we developed a system that uses discrete, recombinant proteins as the vehicles for natural product isolation. Here, we describe the use of this functional chromatographic method to identify natural products that bind to the AAA+ chaperone, p97, a promising cancer target. Application of this method to a panel of fungal and plant extracts identified rheoemodin, 1‐hydroxydehydroherbarin, and phomapyrrolidone A as distinct p97 modulators. Excitingly, each of these molecules displayed a unique mechanism of p97 modulation. This discovery provides strong support for the application of functional chromatography to the discovery of protein modulators that would likely escape traditional high‐throughput or phenotypic screening platforms.     

Ecosystem matters: fish consumption, mercury intake and exposure among fluvial lake fish-eaters

Many studies use the number of fish meals as an estimate of Hg intake, although fish Hg concentrations, even within the same species, can greatly vary. Furthermore, most freshwater advisories only refer to local catch, while market fish advisories only focus on market fish, although both can contribute to Hg body burden. The present study, carried out in lakeside communities from 2 ecosystems in Quebec, Canada, sought to (i) estimate Hg intake from local freshwater sources, hunted waterfowl and market fish and seafood, and (ii) examine the relations between fish consumption, estimated Hg intake and biomarkers of exposure. A total of 238 adults (18-74 years), who had consumed local catch within the past three months, responded to an extensive interview-administered fish and waterfowl frequency questionnaire. Anthropometric measures were taken and a self-administered questionnaire was used to obtain socio-demographic information. Hg intake was estimated as µg Hg/kg body weight/day. Blood and hair samples were analyzed for Hg content. Results showed that persons from one ecosystem ate significantly more fish compared to those from the other (median: 52.1 g/day vs 38.9 g/day), but presented significantly lower concentrations of hair Hg (median: 448.0 ng/g vs 730.5 ng/g), blood organic Hg (median: 1.1 µg/L vs 3.4 µg/L) and inorganic Hg (median: 0.4 µg/L vs 0.8 µg/L). Median daily total Hg intake was 0.080 µg/kg bw/day for the former community and 0.141 µg/kg bw/day for the latter. Overall, 59.5% from the first ecosystem and 41.0% from the other, exceeded the US EPA RfD (0.1 µg/kg bw/day), while 13.2% and 6.0%, respectively, exceeded the Canadian tolerable daily intake (0.47 µg/kg bw/day) for adults. For the two groups, freshwater fish consumption frequency, but not total fish, was positively associated with bioindicators of Hg while estimated Hg intake from freshwater catch as well as from total fish consumption were positively related to Hg biomarkers. There was a positive relation between consumption and estimated Hg intake from freshwater fish and blood inorganic Hg. These findings indicate that the number of fish can be a poor surrogate for Hg exposure. The differences observed here for Hg intake and exposure reflect ecosystem disparities in fish diversity and Hg bioaccumulation. Studies and advisories need to consider Hg fish concentrations and fish-eating patterns in different ecosystems, as well as the contribution of market fish. The relation between fish consumption and inorganic Hg exposure, reported as well in other studies, needs to be further investigated.     

Towards ecological management of Australian powerline corridor vegetation

Powerline corridor management in Australia has traditionally focused on the complete removal of vegetation using short rotation times due to the perceived fire hazard associated with corridor vegetation. This study assessed vegetation recovery in a powerline corridor, following management, at three sites spanning corridor and forest habitat. Forest and corridor vegetation communities differed significantly between sites and over time. As vegetation recovered, the corridor community became a mix of plants common in the surrounding forest and open areas, changing within the 3-year study from a grass–fern to shrub–sedge community encroached by midstorey species. The current short rotations between management events unnecessarily maintain the corridor in a cycle of degradation, remove resources for native species and may allow introduced grasses and saplings to proliferate in the corridor. Maintaining a shrub layer would help avoid loss of species richness, encourage native species and limit colonisation opportunities of introduced species. Spot spraying emergent saplings and problem plants and mosaic slashing, would keep fire risk low and maintain biodiversity without increasing biomass to dangerous levels.