Natural type selection in adaptive lossy compression

Consider approximate (lossy) matching of a source string ~P, with a random codebook generated from reproduction distribution Q, at a specified distortion d. Previous work determined the minimum coding rate R₁=R(P, Q, d) for this setting. We observe that for a large word length and with high probability, the matching codeword is typical with a distribution Q₁ which is different from Q. If a new random codebook is generated ~Q₁, then the source string will favor codewords which are typical with a new distribution Q₂, resulting in a minimum coding rate R₂=R(P, Q₁, d), and so on. We show that the sequences of distributions Q₁, Q ₂,... and rates R₁, R₂,..., generated by this procedure, converge to an optimum reproduction distribution Q*, and the rate-distortion function R(P, d), respectively. We also derive a fixed rate-distortion slope version of this natural type selection process. In the latter case, an iteration of the process stochastically simulates an iteration of the Blahut-Arimoto (1972) algorithm for rate-distortion function computation (without recourse to prior knowledge of the underlying source distribution). To strengthen these limit statements, we also characterize the steady-state error of these procedures when iterating at a finite string length. Implications of the main results provide fresh insights into the workings of lossy variants of the Lempel-Ziv algorithm for adaptive compression     

Visual short-term memory in the first year of life: Capacity and recency effects.

A span task was developed to assess the amount of information infants could hold in short-term memory. In this task, infants were presented with up to 4 items in succession and then tested for recognition by successively pairing each item with a novel one. A large sample of full-terms and low-birth-weight preterms (     

Intact implicit habit learning in Alzheimer's disease.

Habit learning refers to the incremental implicit learning of associations. Patients with Alzheimer's disease (AD) exhibit deficits in explicit memory and in conceptual implicit memory tasks that rely on the cortical areas damaged in AD. The authors tested patients with AD and controls on a probabilistic classification task in which participants implicitly acquire cue-outcome associations. Both groups showed evidence of learning across 50 trials, and performance did not differ significantly between the groups. In contrast, patients with AD exhibited a profound impairment in explicit memory for the testing episode. These results are consistent with the idea that habit learning relies on subcortical structures, including the basal ganglia, and is independent of the medial temporal and cortical areas damaged in AD. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Definition of the Geometric Area of a Microelectrode Tip by Plasma Etching of Parylene

The geometric area of the tip of an intracortical stimulation electrode can be defined by combining photoresist masking with oxygen plasma etching of Parylene.1 The method was tested with both capacitor and iridium oxide electrodes and caused no significant degradation of the electrical properties of the electrode.     

Integrating language and gesture in infancy.

Whether language/gesture correlations in early language development can be explained by parallelism or comprehension mediation was examined. Study 1, parental report data for 95 1-year olds, suggested that word comprehension and production are dissociated in this age range and that the comprehension and production factors map onto distinct aspects of gesture. Study 2 tested 41 13–15-month-olds in a task in which the modeled gesture was accompanied by supportive, contradictory, or neutral narratives. Results showed that infants can use adult speech as an aid in reproduction of modeled gestures (comprehension mediation). However, there is still additional variance in gestural production that correlates with expressive vocabulary when comprehension-related variance is moved. Thus, comprehension mediation and parallelism both appear to be operating. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Air plasma spray processing and electrochemical characterization of SOFC composite cathodes

Air plasma spraying has been used to produce porous composite cathodes containing (La_0.8Sr_0.2)_0.98MnO_3−y (LSM) and yttria-stabilized zirconia (YSZ) for use in solid oxide fuel cells (SOFCs). Preliminary investigations focused on determining the range of plasma conditions under which each of the individual materials could be successfully deposited. A range of conditions was thereby determined that was suitable for the deposition of a composite cathode from pre-mixed LSM and YSZ powders. A number of composite cathodes were produced using different combinations of parameter values within the identified range according to a Uniform Design experimental grid. Coatings were then characterized for composition and microstructure using EDX and SEM. As a result of these tests, combinations of input parameter values were identified that are best suited to the production of coatings with microstructures appropriate for use in SOFC composite cathodes. A selection of coatings representative of the types of observed microstructures were then subjected to electrochemical testing to evaluate the performance of these cathodes. From these tests, it was found that, in general, the coatings that appeared to have the most suitable microstructures also had the highest electrochemical performances, provided that the deposition efficiency of both phases was sufficiently high.     

A randomized trial of nicotine replacement therapy in combination with reduced-nicotine cigarettes for smoking cessation

A randomized double-blind, active controlled, parallel group, multi-center phase II clinical trial was conducted to evaluate the efficacy of reduced-nicotine cigarettes as a novel smoking cessation treatment (under Investigational Device Exemption 69,185). The concept for a reduced-nicotine cigarette designed to progressively wean smokers from the smoking habit is based on research demonstrating that successful smoking cessation is not only dependent on withdrawal of nicotine, but also on weaning from the habitual sensory and behavioral reinforcement of smoking. Treatment consisted of Quest brand of cigarettes (Quest 1, 2, and 3), which respectively deliver 0.59+/-0.06, 0.3+/-0.05, and less than 0.05 mg nicotine, either alone or in combination with nicotine replacement therapy (NRT). The primary endpoint was 4 weeks of continuous abstinence (Weeks 7-10), with additional follow-up at 3 and 6 months. Adult men and women smokers (N = 346), motivated to quit, were randomized to one of three treatment groups: Quest plus NRT (NRT pretreatment 2 weeks before, and NRT after the quit date), Quest plus placebo patch, or active control plus NRT (conventional cigarette, followed by NRT after quit date). Results showed that Quest plus NRT was more effective than active control plus NRT in achieving 4 weeks of continuous abstinence (32.8% vs. 21.9%). Quest plus placebo patch yielded an abstinence rate similar to that of the active control plus NRT (16.4% vs. 21.9%). No serious adverse events were attributable to the investigational product. Quest plus NRT offers promise as a new smoking cessation treatment.     

Rational cubic spirals

We consider the problem of finding parametric rational Bézier cubic spirals (planar curves of monotonic curvature) that interpolate end conditions consisting of positions, tangents and curvatures. Rational cubics give more design flexibility than polynomial cubics for creating spirals, making them suitable for many applications. The problem is formulated to enable the numerical robustness and efficiency of the solution-algorithm which is presented and analyzed.