Experimental Electronuclear Setup at the Institute of Theoretical and Experimental Physics

The purpose and current construction status, at the Institute of Theoretical and Experimental Physics, of an experimental electronuclear setup, combining a pulsed proton linear accelerator (36 MeV, 0.5 mA) and a subcritical blanket thermal-power assembly 100 kW, are discussed. The main equipment is already available or is being built in industry. The setup can be used to investigate the dynamics of the interaction of a linac–driver and a subcritical reactor and problems concerning the accelerator–driver and the target–blanket assembly. The proton beams and neutron fluxes will be used for applied purposes. In the future it will be possible to increase substantially the current and energy of the proton beam.     

Rheological and drug‐release behaviour of a scleroglucan gel matrix at different drug loadings

The aim of this study was to investigate the drug‐loading effects on release and mechanical properties of a scleroglucan gel, with the intention of considering them in delivery systems formulations. The rheological and kinetic properties of a 2 % w/w scleroglucan gel matrix loaded with 0, 0.02, 0.04, 0.06, 0.2 and 0.4 % w/w of theophylline (Th, used as a model drug) were investigated. Rheological measurements were performed in a controlled‐stress rotational‐shear rheometer under isothermal conditions. For theophylline release from the gel a flat Franz cell was used and the kinetic parameters were derived applying a semi‐empirical power law. The influence of scleroglucan molar weight on kinetic and rheological behaviour was also studied. Results suggest two possible effects of drug loading on the gel network: in the 0.04–0.06 % w/w Th range a plasticizing effect and in the 0.2–0.4 % w/w Th range a rigidization effect. In the first range mentioned, the changes in the gel structural properties tested by means of rheological measurements are coincident with changes in drug‐release kinetics. Copyright © 2005 Society of Chemical Industry     

Alphorn: a remote procedure call environment for fault-tolerant,heterogeneous, distributed systems

Alphorn, a software environment for programming distributed computer systems, is described. Programs running on different computers, possibly of different types and running different operating systems, communicate in a client-server relationship by means of remote procedure calls. This efficient construct structures programs neatly. The paper covers distributed process control, Alphorn's object-based programming style, remote procedure calls, the service interface language, configuration, runtime and debugging, and fault tolerance support     

A shell for cooperating expert systems

Abstract: This paper describes a shell for cooperating expert systems that has been developed at the University of Porto. The main goal of this shell is two-fold: to generate a community of cooperative knowledge-based systems and to develop several special reasoning techniques which can be used under a distributed and cooperative paradigm. UPShell is able to convert a set of generated intelligent systems (ISs) into a community of cooperative ISs. In this first version it is already possible to generate different intelligent systems which are able to run 'simultaneously' as separate Unix processes and, using a message-passing mechanism, to communicate among themselves. They can be set to pursue an overall goal in a cooperative way. Moreover, several tasks can be given to each IS to be solved simultaneously, and the IS can switch from task to task according to dynamic priorities reflecting the urgency attached to the specific sub-tasks that emerge. The shell described here may also be used to test, within a distributed environment, some time-bounded reasoning techniques that are presently being developed. The paper has three main parts: a general overview of the UPShell (Section 1); a tutorial explaining, by means of examples, how to use the package (Section 2); and, finally, some considerations on the reasoning techniques used and future improvements (Sections 3–5).