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41.
Moore Kevin J.; Osgood D. Wayne; Larzelere Robert E.; Chamberlain Patricia 《Canadian Metallurgical Quarterly》1994,62(4):718
Pooled time series is an underused analytic technique with the potential to increase researchers' ability to exploit clinical data. This article demonstrates the value of pooled time series by analyzing the behavior of youths in a specialized foster care treatment setting in response to a naturally occurring clinical event: changes in the number of youths living together in a treatment foster care setting. Pooled time series moves beyond typical clinical analyses with an increased capability of controlling statistically for complex within-S effects and with a clinically useful measure of effect size. The complexity of the intra-S data made it virtually impossible to determine the relevant significance (i.e., clinical meaning) of the clinical event by the use of standard n?=?1 visual analysis procedures or standard statistical methods (e.g., chi square). After things such as autocorrelation and individual time trends were statistically controlled, each additional youth increased the number of problematic behaviors by one behavior per youth per day on the Parent Daily Report. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
42.
Intraneural injection of 10-20 x 10(6) viable Mycobacterium leprae into the sciatic nerve of normal, unsensitized, Swiss white mice gives rise to a tuberculoid type of granulomatous response in 2 weeks. The same dose of viable M. leprae when injected into the sciatic nerves of unsensitized immunosuppressed mice (T200 x 5R) elicited a macrophage response. When macrophages were systemically immobilized using an intraperitoneal injection of silica quartz dust in normal mice, the lesion produced was of the lepromatous type, suggesting a role for the macrophage in the induction of the tuberculoid type of granulomatous response. In all of these in situ experiments, M. leprae failed to enter the Schwann cells. 相似文献
43.
Oxygen mass transfer calculations in large arteries 总被引:1,自引:0,他引:1
Parkinsonism is characterised by overactive glutamatergic transmission in the cortico-striatal and subthalamo-medial pallidal pathways. Local blockade of glutamatergic transmission in these pathways can alleviate parkinsonian symptoms. The effectiveness of the treatment, however, is often limited by the simultaneous appearance of unwanted side-effects. These side-effects, including ataxia and dissociative anaesthesia, are particularly problematic when N-methyl-D-aspartate (NMDA) antagonists are used. In an attempt to overcome these problems we have attempted to manipulate excitatory amino acid (EAA)-mediated neurotransmission indirectly by targeting the NMDA receptor associated modulatory sites. We review evidence which demonstrates that antagonists for both the NMDA associated glycine and polyamine sites can reverse parkinsonian symptoms when injected intra-cerebrally in both MPTP-treated and bilateral 6-OHDA lesioned marmosets without eliciting unwanted side-effects. We further review preliminary data which suggest that ifenprodil, a polyamine site antagonist, has striking anti-parkinsonian actions in the marmoset. Potential mechanisms of action underlying these effects are discussed in terms of NMDA receptor subtypes and the neuroanatomical locus of action. The anti-parkinsonian efficacy of intra-striatally administered EAA antagonists leads us to question the view of dopamine acting in the striatum as a simple neuromodulator. 相似文献
44.
Brent M. Phares Glenn A. Washer Dennis D. Rolander Benjamin A. Graybeal Mark Moore 《Canadian Metallurgical Quarterly》2004,9(4):403-413
Routine inspection is the most common form of highway bridge inspection to satisfy the requirements of the National Bridge Inspection Standards. The accuracy and reliability of documentation generated during these inspections are critical to the allocation of Department of Transportation construction, maintenance, and rehabilitation resources. Routine inspections are typically completed using only the visual inspection technique and rely heavily on subjective assessments made by bridge inspectors. In light of this, and given the fact that visual inspection may have other limitations that influence its reliability, the Federal Highway Administration initiated an investigation to examine the reliability of visual inspection as it is currently applied to bridges in the United States. This paper will summarize results from this study related to the accuracy and reliability of routine inspection documentation. A number of important conclusions were developed from the experimental study. Generally, it was found that all structural condition documentation is collected with significant variability. Specifically, 95% of primary element condition ratings for individual bridge components will vary within two rating points of the average and only 68% will vary within one point. Documentation generally collected to support condition ratings also has significant variability as exemplified by the number and types of field notes and photographs taken by inspectors. With respect to the use of element-level inspections, it was found that element usage was generally consistent with the Commonly Recognized Element Guide. However, there is significant variability in the condition state assignments of those elements and in some cases the condition states are not applied correctly to particular elements. 相似文献
45.
Conditioned eyeblink responses are presumably learned in the cerebellum and relayed to motoneurons by way of the red nucleus. Projections from the red nucleus to cerebellar cortex (Larsell's lobule HVI) could be important for shaping temporally adaptive features of the conditioned response. Rabbits that had pipettes containing wheat germ agglutinated horseradish peroxidase (WGA-HRP) implanted unilaterally into HVI showed retrograde labeling of neurons within subregions of the contralateral red nucleus implicated in eyeblink conditioning by lesioning and recording studies. Retrogradely labeled neurons were also observed in the pontine nuclei, inferior olive, and spinal trigeminal nucleus pars oralis. Projections to HVI provide a possible neural substrate for implementing time-derivative computational models of learning in the cerebellum. Time-derivative models are capable of describing the timing and topography of conditioned responses. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
46.
Evaluated the efficacy of outpatient group treatment of chronic pain and the effect of spouse involvement in treatment in chronic pain patients ranging in age from 23 to 69 yrs who were randomly assigned to couples group treatment (n?=?17), patient-only group treatment (n?=?14), or waiting-list controls (n?=?12). 29 Ss had low back pain; the remaining Ss reported pain in the knee, arm, leg, hip, head, and phantom limb. The Ss completed the MMPI—168 and measures of health-related psychosocial and physical dysfunction and marital satisfaction. Results indicate that the 16-hr cognitive-behavioral program produced reductions in pain, somatization, spouse-observed pain behavior, physical and psychosocial dysfunction, spouse-rated dysfunction, and utilization of health care resources. Depression was not affected by treatment. Spouse involvement did not facilitate response to treatment on any variables. Also, Ss in the individual condition only showed improved marital satisfaction. All treatment gains were maintained at 3-mo to 7-mo follow-ups. Results indicate that brief outpatient treatment can significantly ameliorate chronic pain problems, and spouse involvement is not essential for a positive response to treatment. (39 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
47.
48.
When Bonner & Moore was formed in 1956, few-if any-other firms were offering computer consulting services to private industry. Over the years, Bonner & Moore's software development and computer modeling projects took the company far and wide, from Texas oil refineries to the other side of the globe. Its computer services created a solid financial success. 相似文献
49.
50.
Bench-scale reactor experiments were performed to study the dissolution of a binary naphthalene-in-nonane mixture nonaqueous phase liquid (NAPL) pool over a wide range of average pore water velocities, vx (≈0.1–60 m/day). Experimental NAPL pool dissolution flux values were determined using a steady-state mass balance approach. The experimental flux data were compared to model predictions made assuming either local equilibrium or mass-transfer limited conditions. The local equilibrium model could describe the trends in the average effluent concentration and dissolution flux with 0.110?m/day. Data determined to be under mass-transfer limited conditions were fit to the nonequilibrium model to estimate values for an overall mass-transfer coefficient. The calculated overall mass-transfer coefficients had an average value of 0.407 m/day and showed no correlation with vx, probably due to mass-transfer resistance becoming dominated by the diffusional resistance in the NAPL. These results suggest that the nonequilibrium approach is better suited for describing high velocity (vx>10?m/day) dissolution of multicomponent NAPL pools, and that flushing of groundwater at very high velocities may not be an effective approach for enhancing NAPL-pool dissolution flux. 相似文献