Chemotherapy in non-small cell lung cancer: a review

Lung cancer, of which non-small cell carcinoma is the most common, has been a significant therapeutic challenge for decades and will remain so for decades to come. Despite its prevalence, progress in the management of non-small cell lung cancer has been relatively slow. This is in part due to the pessimism of most physicians treating this disease, which has resulted in a relatively lackadaisical attitude with regards to clinical trials when compared to other solid tumours like breast or colorectal cancers. Nevertheless, the past decade has seen significant progress, specifically with regards to the management of locally advanced disease. Chemotherapy, though shown to be biologically active in non-small cell lung cancer, is considered an ineffective palliative tool in the setting of metastatic disease due to its toxicities and the "less than encouraging" response rates generated by the cisplatin-based combination regimen which is generally considered to be the most active currently available. The advent of new active agents such as paclitaxel and vinorelbine which are potentially less toxic may change this view. Conversely, the response rate of locally advanced disease to chemotherapy is significantly higher and this has resulted in numerous multimodality trials of neoadjuvant chemotherapy prior to surgery and/or radiation. To date, a number of randomised trials have shown that this approach can result in significant survival benefit for patients with locally advanced disease. An alternative approach makes use of the potential synergism between certain chemotherapeutic agents (such as cisplatin) and radiation when used concurrently. However, data on concurrent chemoradiotherapy in locally advanced disease have been largely based on single-arm studies and are inconclusive. Three randomised trials on concurrent chemoradiotherapy have been shown benefit for the use of combined modality in locally advanced disease. Hence, treatment of locally advanced disease should include chemotherapy as part of the combined modality approach. However, the optimal sequencing of these modalities would require well-designed randomised trials to determine.     

A simulation-based scheduling system for real-time optimization and decision making support

This paper presents an industrial application of simulation-based optimization (SBO) in the scheduling and real-time rescheduling of a complex machining line in an automotive manufacturer in Sweden. Apart from generating schedules that are robust and adaptive, the scheduler must be able to carry out rescheduling in real time in order to cope with the system uncertainty effectively. A real-time scheduling system is therefore needed to support not only the work of the production planner but also the operators on the shop floor by re-generating feasible schedules when required. This paper describes such a real-time scheduling system, which is in essence a SBO system integrated with the shop floor database system. The scheduling system, called OPTIMISE scheduling system (OSS), uses real-time data from the production line and sends back expert suggestions directly to the operators through Personal Digital Assistants (PDAs). The user interface helps in generating new schedules and enables the users to easily monitor the production progress through visualization of production status and allows them to forecast and display target performance measures. Initial results from this industrial application have shown that such a novel scheduling system can help both in improving the line throughput efficiently and simultaneously supporting real-time decision making.     

Accurate labeling of the light-actinide O(4,5) edges

In this short article, the accurate labeling of the O(4,5) edges of the light actinides is addressed. The O4 and O5 edges are both contained in what is termed the 'giant resonance' and the smaller 'pre-peak' that is observed is a consequence of first-order perturbation by the 5d spin-orbit interaction on the 5d,5f exchange splitting. Thus, the small pre-peak in the actinide 5d-->5f transition should not be labeled the O5 peak, but rather the deltaS = 1 peak.     

Discrimination or favoritism? Sex bias in book reviews.

Studied 180 reviews of books written by male, female, or male and female authors to investigate sex bias. Half the books had been reviewed by males, half by females. Each review was rated separately for positive and negative elements. For positive elements, there was a significant interaction between author's and reviewer's sex: same-sex books were more favorably evaluated than other-sex books, while books of mixed authorship fell in between. There was no comparable interaction for negative elements. Reviewers of both sexes tended to find more negative elements in books by male than by female authors. It is concluded that unlike in studies employing hypothetical situations, in real-life settings each sex is biased in favor of itself. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

"Indianism" and MMPI scores of men alcoholics

Mean MMPI profiles of 40 Indian and 40 White veterans were similar, but "Indianism," as measured by the Indian Culturalization Test, was significantly related to scores on Hs, Hy, Pt and Sc scales. Caution is advised in using the MMPI in the diagnosis of Indians' psychiatric problems.     

Robotic grasping and manipulation through human visuomotor learning

A major goal of robotics research is to develop techniques that allow non-experts to teach robots dexterous skills. In this paper, we report our progress on the development of a framework which exploits human sensorimotor learning capability to address this aim. The idea is to place the human operator in the robot control loop where he/she can intuitively control the robot, and by practice, learn to perform the target task with the robot. Subsequently, by analyzing the robot control obtained by the human, it is possible to design a controller that allows the robot to autonomously perform the task. First, we introduce this framework with the ball-swapping task where a robot hand has to swap the position of the balls without dropping them, and present new analyses investigating the intrinsic dimension of the ball-swapping skill obtained through this framework. Then, we present new experiments toward obtaining an autonomous grasp controller on an anthropomorphic robot. In the experiments, the operator directly controls the (simulated) robot using visual feedback to achieve robust grasping with the robot. The data collected is then analyzed for inferring the grasping strategy discovered by the human operator. Finally, a method to generalize grasping actions using the collected data is presented, which allows the robot to autonomously generate grasping actions for different orientations of the target object.     

An iterative technique for fitting exponentials

An interative method to fit the function \documentclass{article}\pagestyle{empty}\begin{document}$\mathop \[y = \sum\nolimits_i^n { = 1} a_i e^{lix}\] $\end{document} to data is considered. The technique used is that of inversion of a linear differential operator with constant coefficients. This method reproduces the parameters for mathematically precise data and gives satisfactory results when the data are affected by random errors.     

A numerical analysis of the elastic-plastic peel test

The adhesive fracture energy, G_c, is determined from two types of elastic-plastic peel tests (i.e. the single-arm 90° and T-peel methods) and a linear-elastic fracture-mechanics (LEFM) test method (i.e. the tapered double-cantilever beam, TDCB method). A rubber-toughened epoxy adhesive, with both aluminium-alloy and steel substrates, has been used in the present work to manufacture the bonded joints. The peel tests are then modelled using numerical methods. The overall approach to modelling the elastic-plastic peel tests is to employ a finite-element analysis (FEA) approach and to model the crack advance through the adhesive layer via a node-release technique, based upon attaining a critical plastic strain in the element immediately ahead of the crack tip. It is shown that this ‘critical plastic strain fracture model (CPSFM)’ results in predicted values of the steady-state peel loads which are in excellent agreement with the experimentally-measured values. Also, the resulting values of G_c, as determined using the FEA CPSFM approach, have been found to be in excellent agreement with values from previously-reported analytical and direct-measurement methods. Further, it has been found that the calculated values of G_c are independent of whether a standard LEFM test or an elastic-plastic peel test method is employed. Therefore, it has been demonstrated that the value of the adhesive fracture energy, G_c, is independent of the geometric parameters studied and the value of G_c is indeed a characteristic of the joint, in this case for cohesive fracture through the adhesive layer. Finally, it is noted that the FEA CPSFM approach promises considerable potential for the analysis of peel tests which involve very extensive plastic deformation of the peeling arm and for analysing, and predicting, the performance of more complex adhesively-bonded geometries which involve extensive plastic deformation of the substrates.