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排序方式: 共有2423条查询结果,搜索用时 31 毫秒
61.
62.
GM Weinstock JM Hardham MP McLeod EJ Sodergren SJ Norris 《Canadian Metallurgical Quarterly》1998,22(4):323-332
Covert brain activity related to task-free, spontaneous (i.e. unrequested), emotional evaluation of human face images was analysed in 27-channel averaged event-related potential (ERP) map series recorded from 18 healthy subjects while observing random sequences of face images without further instructions. After recording, subjects self-rated each face image on a scale from "liked" to "disliked". These ratings were used to dichotomize the face images into the affective evaluation categories of "liked" and "disliked" for each subject and the subjects into the affective attitudes of "philanthropists" and "misanthropists" (depending on their mean rating across images). Event-related map series were averaged for "liked" and "disliked" face images and for "philanthropists" and "misanthropists". The spatial configuration (landscape) of the electric field maps was assessed numerically by the electric gravity center, a conservative estimate of the mean location of all intracerebral, active, electric sources. Differences in electric gravity center location indicate activity of different neuronal populations. The electric gravity center locations of all event-related maps were averaged over the entire stimulus-on time (450 ms). The mean electric gravity center for disliked faces was located (significant across subjects) more to the right and somewhat more posterior than for liked faces. Similar differences were found between the mean electric gravity centers of misanthropists (more right and posterior) and philanthropists. Our neurophysiological findings are in line with neuropsychological findings, revealing visual emotional processing to depend on affective evaluation category and affective attitude, and extending the conclusions to a paradigm without directed task. 相似文献
63.
Pancreatic cancer is a dismal disease. The 5-year overall survival ranges from 1% to 5%. Surgery is the only curative treatment available for this cancer, but it is indicated only in selected patients with a less than 4 cm tumor. In these patients, survival rate is about 30%. We have considered several aspects: the very difficult early diagnosis, the correct diagnostic flow chart, actual surgical procedures and new trends in biologic and genetic research. It is likely that better results can be achieved by defining an "early pancreatic cancer" and establishing how to detect it. This could be the wrigth one way is to significantly improve the survival of these patients. 相似文献
64.
T Ikeda Y Murata EJ Quilligan JT Parer IM Theunissen P Cifuentes S Doi SD Park 《Canadian Metallurgical Quarterly》1998,179(5):1329-1337
OBJECTIVE: We previously showed that in asphyxiated fetal lambs the duration of hypotension correlated well with the severity of histologic damage to the brain, whereas the duration of bradycardia did not. This study compares fetal heart rate patterns with the degree of histologic damage to the brain. STUDY DESIGN: Twelve chronically instrumented near-term fetal lambs were subjected to asphyxia by umbilical cord occlusion until fetal arterial pH was <6. 9 and base excess was <-20 mEq/L. An additional 4 fetuses served as sham-asphyxia controls. Fetal heart rate (from electrocardiogram), arterial blood pressure, fetal breathing movements, and electrocorticogram were continuously monitored before, during, and for 72 hours after asphyxia. Fetal brain histologic features were categorized as mild (group 1, n = 5), moderate (group 2, n = 4), and severe (group 3, n = 3). Long-term fetal heart rate variability expressed as amplitude range was assessed visually every 5 minutes from 30 minutes before asphyxia until 2 hours of recovery and at 6, 12, 24, 48, and 72 hours of recovery. RESULTS: Long-term fetal heart rate variability amplitude decreased from 32 +/- 17 beats/min (mean +/- SEM) preocclusion to 4 +/- 13 beats/min at the end of occlusion (P <.001) without significant differences among the 3 groups. During 10 to 45 minutes of recovery, the long-term variability of group 1 was significantly greater than that of groups 2 and 3. At 24 to 72 hours of recovery, the long-term variability of groups 1 and 2 was significantly higher than that of group 3, which was almost 0. The "checkmark" and sinusoidal fetal heart rate patterns were observed during the recovery period in groups 2 and 3. CONCLUSIONS: Decreased long-term fetal heart rate variability and the "checkmark" and sinusoidal fetal heart rate patterns were indicators of the severity of asphyxial histologic damage in the fetal brain. 相似文献
65.
M Delgado EJ Munoz-Elias Y Kan I Gozes M Fridkin DE Brenneman RP Gomariz D Ganea 《Canadian Metallurgical Quarterly》1998,273(47):31427-31436
66.
BK Yoder WG Richards C Sommardahl WE Sweeney EJ Michaud JE Wilkinson ED Avner RP Woychik 《Canadian Metallurgical Quarterly》1996,50(4):1240-1248
Autosomal recessive polycystic kidney disease (ARPKD) is characterized by the formation of large collecting tubule and ductular cysts that often result in renal insufficiency within the first decade of life. Understanding the process leading to cyst formation will require the identification and characterization of genes involved in the etiology of this disease. In this regard, we previously described the generation of a mouse model (TgN737Rpw) for ARPKD and the cloning of a candidate gene. Here we show direct involvement of the Tg737 gene in collecting duct cyst formation by expressing the wild-type Tg737 cDNA as a transgene in TgN737Rpw mutants. In contrast to TgN737Rpw mutants, the "rescued" animals survive longer, have normal renal function and normal localization of the EGFr to the basolateral surfaces of collecting duct epithelium. 相似文献
67.
P Gennis L Miller EJ Gallagher J Giglio W Carter N Nathanson 《Canadian Metallurgical Quarterly》1996,3(6):568-573
Thirty-five male patients, aged 34-79 yr, with definite rheumatoid arthritis (RA) were recruited from out-patient clinics and randomized to receive monthly injections of testosterone enanthate 250 mg or placebo as an adjunct therapy for 9 months. Endpoints included disease activity parameters and bone mineral density (BMD). At baseline, there were negative correlations between the ESR and serum testosterone (r = -0.42, P < 0.01) and BMD (hip, r = -0.65, P < 0.01). A total of 29.6% of all patients had at least one vertebral fracture, most having multiple fractures. Back pain, however, was not more prevalent in fracture patients (55% vs 50%). Disease activity was significantly higher in the fracture group (joint score P < 0.05, rheumatoid factor P < 0.01). Thirty patients completed the trial, 15 receiving testosterone and 15 receiving placebo. There were significant rises in serum testosterone, dihydrotestosterone and oestradiol in the treatment group. There was no significant effect of treatment on disease activity overall, five patients receiving testosterone underwent a "flare'. Differences in mean BMD following testosterone or placebo were non-significant (spine: +1.2% vs -1.1%; femur: -0.3% vs +0.3%). There was no suggestion of a positive effect of testosterone on disease activity in men with RA. 相似文献
68.
Benjamin Höferlin Markus Höferlin Daniel Weiskopf Gunther Heidemann 《Multimedia Tools and Applications》2011,55(1):127-150
Automated video analysis lacks reliability when searching for unknown events in video data. The practical approach is to watch
all the recorded video data, if applicable in fast-forward mode. In this paper we present a method to adapt the playback velocity
of the video to the temporal information density, so that the users can explore the video under controlled cognitive load.
The proposed approach can cope with static changes and is robust to video noise. First, we formulate temporal information
as symmetrized Rényi divergence, deriving this measure from signal coding theory. Further, we discuss the animated visualization
of accelerated video sequences and propose a physiologically motivated blending approach to cope with arbitrary playback velocities.
Finally, we compare the proposed method with the current approaches in this field by experiments and a qualitative user study,
and show its advantages over motion-based measures. 相似文献
69.
Yiannis Verginadis Antonis Michalas Panagiotis Gouvas Gunther Schiefer Gerald Hübsch Iraklis Paraskakis 《Journal of Grid Computing》2017,15(2):219-234
Enterprises increasingly recognize the compelling economic and operational benefits from virtualizing and pooling IT resources in the cloud. Nevertheless, the significant and valuable transformation of organizations that adopt cloud computing is accompanied by a number of security threats that should be considered. In this paper, we outline significant security challenges presented when migrating to a cloud environment and propose PaaSword – a novel holistic framework that aspires to alleviate these challenges. Specifically, the proposed framework involves a context-aware security model, the necessary policies enforcement mechanism along with a physical distribution, encryption and query middleware. 相似文献
70.
We propose a new algorithm for vector quantization, the Activity Equalization Vector quantization (AEV). It is based on the winner takes all rule with an additional supervision of the average node activities over a training interval and a subsequent re-positioning of those nodes with low average activities. The re-positioning is aimed to both an exploration of the data space and a better approximation of already discovered data clusters by an equalization of the node activities. We introduce a learning scheme for AEV which requires as previous knowledge about the data only their bounding box. Using an example of Martinetz et al. [1], AEV is compared with the Neural Gas, Frequency Sensitive Competitive Learning (FSCL) and other standard algorithms. It turns out to converge much faster and requires less computational effort. 相似文献