Predicting compensation among MBA graduates five and ten years after graduation.

To predict earnings 5 and 10 yrs after graduation for MBAs, regression models were developed on a sample of 266 graduates and validated against a new set of 70. The predictors included personality tests administered shortly after entrance into the MBA program, age at graduation, business aptitude tests, GPA, and earnings at graduation and at 5 and 10 yrs after graduation. Separate analyses were run for predictors available (a) at entrance, (b) at graduation, and (c) 5 yrs after graduation. The cross-validation multiple correlations for predicting 10-yr earnings were .38, .45, and .65, respectively. Significant predictor variables included the Harrell High Earner's Scale and 2nd-yr GPA. Age at graduation was significant in predicting 5- but not 10-yr earnings. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stimulus-seeking behavior in three delinquent personality types.

Examined stimulus-seeking behavior in 3 delinquent personality types (psychopathic, neurotic, and socialized) drawn from 3 populations (juvenile delinquents, young adult offenders, and college students). 10 Ss were selected from each population with mean ages of 15.2, 20.6, and 19.0 yrs, respectively. Results from a kinesthetic aftereffect task and the Sensation-Seeking Scale indicate only limited evidence of pathological stimulus seeking by the psychopathic delinquent personality type. It is suggested that this limited evidence results from the incarceration experiences of the young adult offenders. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice

Expression of the homeobox fusion gene E2A-PBX1 under control of the immunoglobulin heavy chain enhancer efficiently induced malignancies in transgenic mice. All animals died before 5 months of age with lymphomas that demonstrated phenotypes consistent with transitional intermediate thymocytes (CD4+/CD8+/CD3med). E2A-PBX1 also markedly altered lymphoid development in pretumorous animals, reducing the number of thymocytes and bone marrow B lineage progenitors to 20% of normal levels. In spite of the observed reductions in lymphoid cells, premalignant animals contained significantly increased numbers of cycling thymocytes, but a higher proportion was also undergoing apoptosis, suggesting that increased cell death resulted in the marked lymphopenias. These data indicate that the chimeric homeodomain protein E2A-PBX1 paradoxically induces both proliferation and apoptosis in lymphoid cells, suggesting an in vivo association between nuclear oncogene-induced cell cycle progression and programed cell death.     

Pathological changes in the nucleus of Meynert in Alzheimer's and Parkinson's diseases

Combined neuropathological and neurochemical assessment of the nucleus of Meynert in senile dementia of Alzheimer type (SDAT) have demonstrated that the cholinergic biochemical activity, choline acetyltransferase, is more extensively reduced in the nucleus (over 90%) than the loss of putative cholinergic perikarya (35%). Acetylcholinesterase histochemical activity was however substantially retained in individual neurones in the nucleus although virtually absent from the neocortex in SDAT. These abnormalities are consistent with a primary degeneration of cholinergic axons projecting to the cortex and secondary loss of perikarya from the subcortical nucleus. In contrast, preliminary observations on cases of Parkinson's disease suggest that the neuronal loss from the nucleus of Meynert may be greater in this disease than in SDAT, and previous studies have not consistently demonstrated a reduction in cortical choline acetyltransferase activities in Parkinson's disease. These observations, together with major differences in the neuropathology of the nucleus in SDAT and Parkinson's disease (neurofibrillary tangle and Lewy body formation, respectively) suggest that the involvement of the cholinergic system may differ in the two disease processes.     

Changes in the motor response threshold to direct electric stimulation of the motor cortex during elaboration of conditioned reflex switching-over

During elaboration of switching-over of an alimentary salivary conditioned reflex to a defensive one in dogs, with foreleg passive flexion as a signal stimulus, excitability changes of opposite signs appeared in the cortical representation of the left foreleg. At the stage of elaborated switching-over, the threshold of the flexor reaction to a direct stimulation of the motor cortex became lower in the alimentary experimental situation (passive rise--milk) and rose in the defensive situation (passive rise--acid).