The New ATTIS and NTI Approach to Integrating Voice and Data

Abstract

Because most of the expenses in an MIS budget are not as apparent as other departmental budgets, senior managers often cut the MIS budget when they need to control financial costs – without realizing the impact on end-user departments. To avoid these arbitrary cuts, MIS managers face the difficult task of justifying their budget increases. This column describes how MIS managers can save their budgets from unnecessary cuts by promoting MIS expenses as capital investments and by planning for future costs.     

Effect of contrast concentration on abdominal enhancement in the rabbit: spiral computed tomography evaluation

BACKGROUND: Langerhans' cell histiocytosis (LCH) is an uncommon, poorly understood granulomatous disease, characterized by the idiopathic proliferation of Langerhan's cells or their marrow precursors. In 1985, the Philadelphia Work-shop adopted the term "Langerhans' cell histiocytosis" (LCH) to differentiate it from reactive and neoplastic causes of histiocytosis. METHODS: This study includes 73 pediatric patients diagnosed with this condition in Dublin, Ireland, and Nottingham, England, during a 34-year period (1959 to 1993). These patients are reviewed with respect to clinical presentation, difficulty with making a histological diagnosis, their management, and outcome. RESULTS: A total of 49 patients (67%) had head and neck involvement. Bony involvement was the most frequent sign, most frequently located in the skull. There were 11 deaths (15%) in this series, all associated with multisystem disease, and nine of these deaths were in children younger than 2 years of age. CONCLUSIONS: The role of otolaryngologists is important in the early and accurate evaluation, staging, and diagnosis of LCH. It may mimic more common diseases, such as otitis externa, acute mastoiditis, skin rash, gingivitis, or cervical lymphadenopathy. Patients with multisystem disease may be so ill at presentation that the head and neck lesions may be overlooked. The current management of LCH has become increasingly conservative, and in the 1990s, fewer cases are given chemotherapy or radiotherapy. The prognosis is very good for single-system disease and poor for multisystem disseminated disease with early onset.     

Electrophysiological evidence for a postperceptual locus of suppression during the attentional blink

When an observer detects a target in a rapid stream of visual stimuli, there is a brief period of time during which the detection of subsequent targets is impaired. In this study, event-related potentials (ERPs) were recorded from normal adult observers to determine whether this "attentional blink" reflects a suppression of perceptual processes or an impairment in postperceptual processes. No suppression was observed during the attentional blink interval for ERP components corresponding to sensory processing (the P1 and N1 components) or semantic analysis (the N400 component). However, complete suppression was observed for an ERP component that has been hypothesized to reflect the updating of working memory (the P3 component). Results indicate that the attentional blink reflects an impairment in a postperceptual stage of processing.     

Speech perception performance in experienced cochlear-implant patients receiving the SPEAK processing strategy in the Nucleus Spectra-22 cochlear implant

Sixteen experienced cochlear implant patients with a wide range of speech-perception abilities received the SPEAK processing strategy in the Nucleus Spectra-22 cochlear implant. Speech perception was assessed in quiet and in noise with SPEAK and with the patients' previous strategies (for most, Multipeak) at the study onset, as well as after using SPEAK for 6 months. Comparisons were made within and across the two test sessions to elucidate possible learning effects. Patients were also asked to rate the strategies on seven speech recognition and sound quality scales. After 6 months' experience with SPEAK, patients showed significantly improved mean performance on a range of speech recognition measures in quiet and noise. When mean subjective ratings were compared over time there were no significant differences noted between strategies. However, many individuals rated the SPEAK strategy better for two or more of the seven subjective measures. Ratings for "appreciation of music" and "quality of my own voice" in particular were generally higher for SPEAK. Improvements were realized by patients with a wide range of speech perception abilities, including those with little or no open-set speech recognition.     

Composition and formation of the sleeve enveloping a central venous catheter

PURPOSE: After catheterization, 42% to 100% of central venous catheters are surrounded by a "fibrin sleeve." This sleeve has been considered the cause of catheter-related infections, withdrawal occlusion, and pulmonary embolism. The reactions between the vein wall and the catheter were studied. METHODS: A silicone catheter was placed in the anterior caval vein of 123 rats. After in situ fixation at scheduled intervals, the pathologic changes were studied on semi-serial histologic sections by means of light microscopy, transmission electron microscopy, and scanning electron microscopy (SEM). In 36 rats, the catheter was withdrawn immediately; in 72 rats, it was left in situ up to 6 months; and in 15 rats, the study was performed up to 10 months after withdrawal of a catheter that had remained in situ for 6 months. RESULTS: In the group in which the catheter was withdrawn immediately, mural thrombi disappeared by day 7. In the group in which the catheter remained in situ, thrombi remained around the proximal portion of the catheter. This pericatheter thrombosis (PCT) was invaded by migrating and proliferating smooth muscle cells (SMCs), originating from an injured vein wall, and transformed from day 7 into a tissue composed predominantly of SMCs and collagen and covered by endothelial cells. Later, the number of cells decreased, and the relative amount of collagen increased. Up to 10 months after withdrawal of the catheter, the collapsed sleeve was still present within the vein. CONCLUSION: The sleeve around a central venous catheter is not a fibrin sleeve, but a stable cellular-collagen tissue covered by endothelium. It is mainly formed by smooth muscle cells migrating from the injured vein wall into the early pericatheter thrombus.     

Efficient computation of distance labeling for decremental updates in large dynamic graphs

Since today’s real-world graphs, such as social network graphs, are evolving all the time, it is of great importance to perform graph computations and analysis in these dynamic graphs. Due to the fact that many applications such as social network link analysis with the existence of inactive users need to handle failed links or nodes, decremental computation and maintenance for graphs is considered a challenging problem. Shortest path computation is one of the most fundamental operations for managing and analyzing large graphs. A number of indexing methods have been proposed to answer distance queries in static graphs. Unfortunately, there is little work on answering such queries for dynamic graphs. In this paper, we focus on the problem of computing the shortest path distance in dynamic graphs, particularly on decremental updates (i.e., edge deletions). We propose maintenance algorithms based on distance labeling, which can handle decremental updates efficiently. By exploiting properties of distance labeling in original graphs, we are able to efficiently maintain distance labeling for new graphs. We experimentally evaluate our algorithms using eleven real-world large graphs and confirm the effectiveness and efficiency of our approach. More specifically, our method can speed up index re-computation by up to an order of magnitude compared with the state-of-the-art method, Pruned Landmark Labeling (PLL).     

The stretch zone of automotive steel sheets

The paper deals with an experimental determination of the stretch zone dimensions in the notch tip in thin steel sheets. The stretch zone dimensions depend on steel grade, on the rolling direction as well as on the loading rate. Stretch zones were observed and measured on three steel grades. Fracture area and stretch zones were analysed by SEM. Stable crack growth was monitored by videoextensometry techniques on CT (Compact Tension) specimens. Specimens were loaded under two loading rates by eccentric tension, whereby the deformation in the notch surrounding area was recorded using a non-contact measurement–videoextensometry technique. Linear relation between the stretch zone dimensions was determined.     

Three-dimensional imaging of human stem cells using soft X-ray tomography

Three-dimensional imaging of human stem cells using transmission soft X-ray tomography (SXT) is presented for the first time. Major organelle types—nuclei, nucleoli, mitochondria, lysosomes and vesicles—were discriminated at approximately 50 nm spatial resolution without the use of contrast agents, on the basis of measured linear X-ray absorption coefficients and comparison of the size and shape of structures to transmission electron microscopy (TEM) images. In addition, SXT was used to visualize the distribution of a cell surface protein using gold-labelled antibody staining. We present the strengths of SXT, which include excellent spatial resolution (intermediate between that of TEM and light microscopy), the lack of the requirement for fixative or contrast agent that might perturb cellular morphology or produce imaging artefacts, and the ability to produce three-dimensional images of cells without microtome sectioning. Possible applications to studying the differentiation of human stem cells are discussed.     

Exploring scenarios for the future of energy management in UK property

The most appropriate responses to the energy management of buildings from now until 2050 are investigated through a process of scenario planning. A qualitative, explorative approach was undertaken to develop four 2050 scenario end-states resulting from an axis of two critical uncertainties not closely correlated: the attitudes of society towards sustainability; and the availability of energy. These scenarios were applied to the property industry through expert workshops, from which trends and themes were identified. The findings are that the property industry should prepare for a transitional period with an uncertain outlook. Therefore, it would be prudent for this industry to focus on resilient performance under a diverse set of futures, and plausible shock events, rather than optimizing for today's conditions. This could be challenging in a sector that works on relatively long time scales. Aspects that should be incorporated into property industry strategy are suggested: responding to the potential effects of climate change; understanding what drives communities and investing in buildings that are significant to the community's functions; considering transport links as key to successful property investments; adopting the latest technological innovations; and becoming more ‘full service’ and interdisciplinary. A need for a paradigm shift in the industries' practices was also identified.

Les réponses les plus appropriées à la gestion énergétique des bâtiments d'ici 2050 sont étudiées en ayant recours à un processus de planification par scénarios. Une approche qualitative exploratrice a été adoptée afin de développer quatre conclusions de scénario pour 2050, résultant d'un axe formé par deux incertitudes cruciales qui ne sont pas étroitement corrélées: les attitudes de la société envers la durabilité et la disponibilité de l'énergie. Ces scénarios ont été appliqués à l'industrie de l'immobilier par l'intermédiaire d'ateliers d'experts, grâce auxquels des tendances et des thèmes ont été identifiés. Il en ressort que l'industrie de l'immobilier devrait se préparer à une période de transition offrant des perspectives incertaines. En conséquence, il serait prudent que cette industrie concentre ses efforts sur le maintien de solides performances face à différents avenirs possibles, et à des évènements chocs plausibles, plutôt que sur une optimisation par rapport aux conditions d'aujourd'hui. Ceci pourrait être difficile dans un secteur qui travaille sur des échelles de temps relativement longues. Il est suggéré des aspects qui devraient être intégrés à la stratégie de l'industrie de l'immobilier: répondre aux effets potentiels du changement climatique; comprendre ce qui constitue le moteur des collectivités et investir dans des bâtiments qui soient significatifs pour les fonctions de la collectivité; considérer les liaisons de transport comme essentielles pour des investissements immobiliers réussis; adopter les dernières innovations technologiques; et devenir davantage « un service complet » et interdisciplinaire. A également été identifiée la nécessité d'un changement de paradigme dans les pratiques des industries.

bâtiments, gestion énergétique, planification future, secteur de l'immobilier, résilience, scénarios, incertitude     

Equivalent linear limit states

The replacement of any limit state function by an equivalent linear function is discussed in detail and it is shown that there are several methods by which such an equivalence may be established. In the case of multiple failure mode problems the definition of fully equivalent linear functions requires the additional consideration of mode correlations. The manner in which this may be carried out is discussed and it is shown that, for most practical cases, a relatively simple analysis is likely to be sufficient to define the set of equivalent linear limit states, with the advantage that the established theory of such linear limit states may then be employed in the majority of reliability analyses.