Evolvable hardware techniques for on-chip automated reconfiguration of programmable devices

While complete automated design is a harder problem than computer-assisted design, automated hardware reconfiguration is an even more challenging problem, because it needs to adjust to limited resources and various factors, such as noise and parasitic capacitance, a resistance and inductance. This paper presents some experimental results of on-chip automated design and reconfiguration using evolvable hardware techniques. It describes a stand-alone board level evolvable system, and its use to demonstrate on-chip synthesis of new circuits in only a few seconds. The experiments presented here indicate a recovery capability in the case of extreme environmental conditions, such as extreme temperatures, that adversely affect electronics. Some of the difficulties of dealing with the real hardware are exposed, as well as challenges more generally related to automated evolution of complex electronic systems.The work described in this paper was performed at the Center for Integrated Space Microsystems, Jet Propulsion Laboratory, California Institute of Technology and was sponsored by the Defense Advanced Research Projects Agency and by the National Aeronautics and Space Administration.     

A study of film formation on aluminum in aqueous solutions using Rutherford backscattering spectroscopy

The growth of hydrated surface films on 99.99% pure aluminum in aqueous media at 100°C has been studied with Rutherford backscattering spectroscopy (RBS). The effects of the inhibitor anions borate, molybdate, nitrate, phosphate, sulfate, silicate and tungstate, and of ethylene glycol on this reaction were observed at concentration levels typical of automotive coolant formulations. The behavior of the inorganic anions studied is classified roughly into three types. In the first, typical of silicate, the inhibitor reacts with the surface to both prevent formation of the aluminum hydroxide layer, as well as limit the uptake of additional species by the surface. In a second mode, characteristic of nitrate and sulfate additions, the surface hydroxide develops, but at lower levels than those obtained in pure water. In yet another mode, characteristic of phosphate, molybdate and tungstate, the inhibitor anions are continually incorporated into a growing film which appears to be a hydrated aluminum salt of the particular anion, rather than pseudo-boehmite. Ethylene glycol is found to act primarily as a diluent in reducing the overall rate of film growth in aqueous solutions.     

Physiologic effects of a self-contained self-rescuer

Recently promulgated federal regulations mandate the provision of an emergency, self-contained, oxygen-supplying breathing device (self-contained self-rescuer, SCSR) to all underground coalminers. In order to assist in defining the potential limitations of this new device, we measured the responses of ten healthy coal mine inspectors to submaximal steady-state treadmill exercise with and without the SCSR. During the last minute of exercise, blood oxygen saturation averaged 98.3% and mouth pressure swing 15.6 cm H2O with the device, compared to 94.8% and 10.4 cm H2O without it. Mean respiratory rates were decreased to 25/min with the SCSR from 28/min without it. Blood pressure, core temperature and heart rate were unaffected. We conclude that in healthy individuals on submaximal exercise there is little evidence of a significant adverse effect of the new device.     

Reversal of pretreatment hypotension and control of hemorrhage in trauma patients by a simple device

The injection of a suspension of Walker 256 carcinoma cells into the carotid artery of rats produced a model of hematogenously spread cerebral metastases. Most animals died from massive extracerebral tumors of the head and jaw; brain tumors were present in only one-quarter. External carotid artery ligation prior to tumor inoculation did not increase the incidence of fatal brain tumor. When cyclophosphamide, 15 mg/kg, was injected as a single dose on the fourteenth day after tumor inoculation, most of the extracerebral tumor disappeared. Fifty percent of the animals so treated were cured of tumor, but 90% of the remainder died of large intracerebral tumors. Severe cytopathic changes resulting from cyclophosphamide were present in extracerebral or choroid plexus tumors but were mild or nonexistent in intracerebral tumors. These selective effects of cyclophosphamide suggest that water-soluble agents are less effective against tumor in the brain than against extracerebral tumors despite the fact that metastatic tumor breaks down the blood-brain barrier.     

Hematuria and sickle cell disorders

To examine the relationship between gross hematuria and sickle cell disorders, all patients admitted to Grady Memorial Hospital with the diagnosis of a sickle cell disorder during a 14-month period were reviewed. Of 115 such patients, 65% had sickle cell disease and 35% had sickle cell trait. None of the former but seven of the latter group had gross hematuria. Mean age of the seven was 30 years. Comprehensive examinations and laboratory studies showed that all were free of concomitant disease. Physical findings, diagnostic modalities, and treatment were reviewed. Findings suggest that conservative therapy (bed rest, hydration, and diuresis) is usually effective.     

Anomalous double blood supply to the lung

We report an unusual case in which an apparently normal upper lobe of the right lung was supplied by major systemic arterial and pulmonary arterial vessels. The anomalous artery arose from the descending aorta. Following interruption of this vessel, the machinery-like murmur previously present disappeared.