Physiologic effects of a self-contained self-rescuer

Recently promulgated federal regulations mandate the provision of an emergency, self-contained, oxygen-supplying breathing device (self-contained self-rescuer, SCSR) to all underground coalminers. In order to assist in defining the potential limitations of this new device, we measured the responses of ten healthy coal mine inspectors to submaximal steady-state treadmill exercise with and without the SCSR. During the last minute of exercise, blood oxygen saturation averaged 98.3% and mouth pressure swing 15.6 cm H2O with the device, compared to 94.8% and 10.4 cm H2O without it. Mean respiratory rates were decreased to 25/min with the SCSR from 28/min without it. Blood pressure, core temperature and heart rate were unaffected. We conclude that in healthy individuals on submaximal exercise there is little evidence of a significant adverse effect of the new device.     

Reversal of pretreatment hypotension and control of hemorrhage in trauma patients by a simple device

The injection of a suspension of Walker 256 carcinoma cells into the carotid artery of rats produced a model of hematogenously spread cerebral metastases. Most animals died from massive extracerebral tumors of the head and jaw; brain tumors were present in only one-quarter. External carotid artery ligation prior to tumor inoculation did not increase the incidence of fatal brain tumor. When cyclophosphamide, 15 mg/kg, was injected as a single dose on the fourteenth day after tumor inoculation, most of the extracerebral tumor disappeared. Fifty percent of the animals so treated were cured of tumor, but 90% of the remainder died of large intracerebral tumors. Severe cytopathic changes resulting from cyclophosphamide were present in extracerebral or choroid plexus tumors but were mild or nonexistent in intracerebral tumors. These selective effects of cyclophosphamide suggest that water-soluble agents are less effective against tumor in the brain than against extracerebral tumors despite the fact that metastatic tumor breaks down the blood-brain barrier.     

Hematuria and sickle cell disorders

To examine the relationship between gross hematuria and sickle cell disorders, all patients admitted to Grady Memorial Hospital with the diagnosis of a sickle cell disorder during a 14-month period were reviewed. Of 115 such patients, 65% had sickle cell disease and 35% had sickle cell trait. None of the former but seven of the latter group had gross hematuria. Mean age of the seven was 30 years. Comprehensive examinations and laboratory studies showed that all were free of concomitant disease. Physical findings, diagnostic modalities, and treatment were reviewed. Findings suggest that conservative therapy (bed rest, hydration, and diuresis) is usually effective.     

Anomalous double blood supply to the lung

We report an unusual case in which an apparently normal upper lobe of the right lung was supplied by major systemic arterial and pulmonary arterial vessels. The anomalous artery arose from the descending aorta. Following interruption of this vessel, the machinery-like murmur previously present disappeared.     

Perception of forbidden colors in retinally stabilized equiluminant images: an indication of softwired cortical color opponency?

In color theory and perceptual practice, two color naming combinations are forbidden-reddish greens and bluish yellows-however, when multicolored images are stabilized on the retina, their borders fade and filling-in mechanisms can create forbidden colors. The sole report of such events found that only some observers saw forbidden colors, while others saw illusory multicolored patterns. We found that when colors were equiluminant, subjects saw reddish greens, bluish yellows, or a multistable spatial color exchange (an entirely novel perceptual phenomena); when the colors were nonequiluminant, subjects saw spurious pattern formation. To make sense of color opponency violations, we created a soft-wired model of cortical color opponency (based on winner-take-all competition) whose opponency can be disabled.     

Speaker Verification Using Support Vector Machines and High-Level Features

High-level characteristics such as word usage, pronunciation, phonotactics, prosody, etc., have seen a resurgence for automatic speaker recognition over the last several years. With the availability of many conversation sides per speaker in current corpora, high-level systems now have the amount of data needed to sufficiently characterize a speaker. Although a significant amount of work has been done in finding novel high-level features, less work has been done on modeling these features. We describe a method of speaker modeling based upon support vector machines. Current high-level feature extraction produces sequences or lattices of tokens for a given conversation side. These sequences can be converted to counts and then frequencies of n-gram for a given conversation side. We use support vector machine modeling of these n-gram frequencies for speaker verification. We derive a new kernel based upon linearizing a log likelihood ratio scoring system. Generalizations of this method are shown to produce excellent results on a variety of high-level features. We demonstrate that our methods produce results significantly better than standard log-likelihood ratio modeling. We also demonstrate that our system can perform well in conjunction with standard cesptral speaker recognition systems.     

A New Era of Minimal Effects? A Response to Bennett and Iyengar

This article takes up Bennett and Iyengar's (2008) call for debate about the future of political communication effects research. We outline 4 key criticisms. First, Bennett and Iyengar are too quick to dismiss the importance of attitude reinforcement, long recognized as an important type of political media influence. Second, the authors take too narrow a view of the sources of political information, remaining fixated on news. Third, they offer an incomplete portrayal of selective exposure, exaggerating the extent to which individuals avoid attitude-discrepant information. Finally, they lean toward determinism when describing the role technologies play in shaping our political environment. In addition, we challenge Bennett and Iyengar's assertion that only brand new theory can serve to help researchers understand today's political communication landscape. We argue that existing tools, notably the Elaboration Likelihood Model (ELM), retain much utility for examining political media effects. Contrary to Bennett and Iyengar's claims, the ELM suggests that the contemporary political information environment does not necessarily lead to minimal effects.