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981.
Scleroderma is a connective tissue disorder which includes fibrosis of the skin. Facial skin contraction leads to loss of forehead, periorbital, and nasolabial wrinkling and at the same time causes radial furrows around the contracted oral opening (microstomia). The lips become retracted. We describe a 41 year old lady whose upper lip was treated by free dermal graft and injection of fat to improve her perioral aesthetic appearance. The skin was taken from the right submammary fold and the fat was obtained from the abdomen by liposuction. Excess fat was stored in a sterile container at -70 degrees C for future use. The patient made a satisfactory recovery and has asked for her lower lip to be treated in the same way.  相似文献   
982.
The optical absorption of high lead borate and lead silicate glasses containing manganese before and after γ-ray irradiation was studied. To separate the absorption due to manganese from the intrinsic absorption, blank glasses were prepared and measured. The results showed that the visible absorption band before and after irradiation exhibited changes with the radiation dose and chemical composition of the glass. The response of the glasses to gamma irradiation was related to the creation and spread of defect "color centers," the approach of a saturation condition, and the possible photochemical effect on the transition metal.  相似文献   
983.
The effect of sodium on refractory phase formation in a model Calcium Aluminate Cement–bonded refractory was investigated from 700°C to 1500°C. Sodium reacts with α‐alumina to form sodium β‐alumina (β‐Al2O3) via the intermediate NaAlO2. Formation of β‐Al2O3 disrupts the reaction path of calcia with alumina, delaying crystallization of calcium hexaluminate, CaO·6Al2O3, from 1350°C to 1500°C. β‐Al2O3 is also shown to reduce Young's modulus and delay sintering. The presence of NaAlO2 and β‐Al2O3 result in an increase in internal friction. Increased linear expansion of up to 47% is observed when 1 wt% Na is added. The expansion is shown to scale with the amount of dopant with only 0.3 wt% Na leading to an additional 31% linear expansion. On cooling, the presence of β‐Al2O3 can be demonstrated by a peak in internal friction between 1200°C and 1000°C which could be caused by Na+ ion hopping along the spinel‐like planes.  相似文献   
984.
This paper is concerned with a technique for assessing different degrees of sharpness between flexible card-wire teeth. An Instron Tensile Tester was used to measure the force required to pull strips of granular-faced material over card teeth that differed in both sharpness and density, both ‘with’ and ‘against’ the wire points. Variants introduced included the load applied by the granular material to the teeth and the grit size of the granular material.

It is shown, on the basis of experiments on five different densities of card clothing, each ground to three different degrees of sharpness, that these differences can be quantitatively detected when they are measured against the wire points and that they are in complete agreement with the subjective assessments of wire sharpness.

It seems possible that the principles enunciated in this paper may be used to devise an instrument for detecting differences in wire sharpness.  相似文献   
985.
986.
The wave equation defined on an open bounded regular domain n is considered. The measurement is obtained by means of a pointwise sensor located inside Ω The observability problem of the system is studied using the Hilbert Uniqueness Method developed by Lions and we show that it can be linked with the sensor structure. Morever we obtain from this approach, explicit formulae for the state to be reconstructed. These useful formulae are then implemented numerically and illustrated through two examples.  相似文献   
987.
    
The flagellar fraction (FF) of Trypanosoma cruzi can be separated by immunoaffinity chromatography in two fractions with balanced but opposite immunological effects. The immunoaffinity purified fraction has immunosuppressive activity mediated at least partially by TGF-beta (Hansen et al., submitted). Here we report that the fraction depleted of immunosuppresive antigens (FT) administered with iscom-matrix as adjuvant provides enhanced protection to an infection challenge in immunized mice. In vitro, the FT but not the FF stimulated resident peritoneal cells to produce IL-1 and IL-6. In immunized mice, the FT elicited higher levels of antigen-specific IgG2a than the FF as well as broader recognition of T. cruzi antigens. Splenocytes from mice immunized with FT proliferated spontaneously in vitro and secreted TH1 and TH2 cytokines. The protection provided by FT correlates with its capacity to enhance the secretion of IFN-gamma. We postulate that immunosuppressive antigens present in the FF prevent the development of memory cells secreting IFN-gamma through a TGF-beta dependent mechanism.  相似文献   
988.
    
From evidence of interpatient variability in normal tissue sensitivity to radiotherapy and from radiation studies using inbred mouse strains, it is hypothesized that individual variation in susceptibility to radiation-induced pulmonary fibrosis is genetically controlled. A genetic model has been developed from the fibrosis-prone C57BL/6J and the fibrosis-resistant C3Hf/Kam mouse strains. Inheritance of the fibrotic phenotype was characterized in F1 and F2 (F1 intercross) generations derived from the parental strains. Genetic mapping was used to determine whether the quantitative trait loci (QTL), which influence susceptibility to bleomycin-induced lung fibrosis in these progenitor strains, could be implicated in susceptibility to radiation-induced lung fibrosis. Mice were treated with 14 or 16 Gy (60Co) to the whole thorax. The doses were selected to investigate the response at the LD50 and LD100 of C3Hf/Kam mice. The animals were sacrificed 33 weeks after treatment or when moribund. The percentage of lung with fibrosis for each mouse was quantified with image analysis of a histological section of the lung. For both the 14- and 16-Gy data sets, heritability was estimated at 38 +/- 11%, and the number of genetic factors influencing susceptibility to pulmonary fibrosis was estimated to be one or two. Two hundred fifty-five F2 intercross mice were genotyped with markers at the bleomycin loci on chromosomes 11 and 17 (chromosome 17 marker is at the major histocompatibility complex). Genetic linkage was established for the marker on chromosome 17 (P = 3.0 x 10(-6)), which accounts for 6.6% of the F2 phenotypic variance but not for the markers surrounding the QTL on chromosome 11 (P = 0.37). The inheritance data suggested that susceptibility to radiation-induced pulmonary fibrosis is a heritable trait controlled by two genetic loci, and through genomic mapping, a QTL on chromosome 17 was identified as one of the loci.  相似文献   
989.
    
The purpose of the study was to determine the effect of a low-fat dietary intervention, with or without concomitant tamoxifen adjuvant therapy, on serum estrogen and sex hormone-binding globulin (SHBG) levels in postmenopausal patients with resected breast cancer. Ninety-three patients were randomized to either reduce their fat intake to 15-20% of total calories, or to a dietary control group. Serum estradiol, estrone, estrone sulfate, and SHBG concentrations were assayed at baseline, and at 6, 12, and 18 months thereafter. In 19% of patients, the preintervention serum estradiol levels were below the sensitivity of the assay (5 pg/ml). Tamoxifen had no significant effect on serum estrogen levels, but produced an elevation in SHBG. Patients with reliably quantifiable preintervention estradiol concentrations (> or = 10 pg/ml) showed a significant reduction in serum estradiol after 6 months on the low-fat diet (average, 20%; p < 0.005); this was sustained over the 18 month study period. Serum SHBG levels were increased by tamoxifen therapy, but were reduced significantly (p = 0.01) after 12 months on the low-fat diet in patients not receiving tamoxifen. No changes in serum estrone or estrone sulfate resulted from the dietary intervention. While the low-fat diet produced significant weight loss, patients treated with tamoxifen without dietary intervention showed a gain in body weight. These weight changes produced disruptions in the normal positive correlation between body weight and serum estrone sulfate, and the negative correlation with SHBG concentration.  相似文献   
990.
  总被引:1,自引:0,他引:1  
This article discusses the benefits of different infill sampling criteria used in surrogate-based constrained global optimization. A new method which selects multiple updates based on Pareto optimal solutions is introduced showing improvements over a number of existing methods. The construction of surrogates (also known as meta-models or response surface models) involves the selection of a limited number of designs which are analysed using the original expensive functions. A typical approach involves two stages. First the surrogate is built using an initial sampling plan; the second stage updates the model using an infill sampling criterion to select further designs that offer improvement. Selecting multiple update points at each iteration, allowing distribution of the expensive function evaluations on several processors offers large potential for accelerating the overall optimization process. This article provides a comparison between different infill sampling criteria suitable for selecting multiple update points in the presence of constraints.  相似文献   
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