Effects of pulsatile and nonpulsatile coronary perfusion on performance of the canine left ventricle

This study compares the effect of pulsatile (Group C, Fib/P) and nonpulsatile (Group B, Fib/NP) coronary perfusion on myocardial performance during 2 hours of normothermic ventricular fibrillation. Group A (BH/NP), used as a base-line observation, consisted of 2 hours of nonpulsatile coronary perfusion in beating hearts. The assessment of ventricular performance included diastolic ventricular compliance, myocardial oxygen consumption and lactate extraction, regional myocardial blood flow, and histology. After 120 minutes of ventricular fibrillation, Group C showed normal ventricular diastolic compliance as compared to a 50 per cent decrease in Group B (p less than 0.01). Myocardial oxygen consumption was not significantly different from that in Group B. Because of a 70 per cent increase in oxygen extraction above Group B (p less than 0.05), total left ventricular myocardial blood flow was reduced (103 +/- 23 versus 260 +/- 36 ml. per 100 Gm. per minute, p less than 0.05) and had near-constant resistance. Lactate extraction was significantly greater and more stable as compared to Group B (9.28 +/- 1.33 versus 1.8 +/- 1.08, p less than 0.05). Left ventricular endocardial/epicardial flow ratio was greater in Group C (1.21 +/- 0.08 versus 1.06 +/- 0.06, p less than 0.05). Minimal subendocardial histologic changes were present as compared to the marked patchy subendocardial ischemic changes seen in Group B. The results demonstrate that the addition of pulsatile flow to coronary perfusion minimized the deleterious effects of prolonged ventricular fibrillation on myocardial performance.     

Rational method for preparing and firing Vladimir kaolin in a rotary kiln

Conclusions We tested a technology and selected additives for obtaining strong briquette at low (500–700°C) temperatures and dense chamotte at high firing temperatures in laboratory conditions.Using the newly developed technology in semi-industrial conditions we obtained chamotte, and the dust emission was reduced by a factor of ten, while the amount of large fractions was more than doubled compared with those obtained when firing kaolin without additions.A certain improvement was noted in the sintering of kaolin into chamotte, in the case of preheating of specimens to 600–900°C, and subsequent rapid firing at high temperatures.Translated from Ogneupory, No. 7, pp. 11–17, July, 1968.     

精密光栅位移传感器的若干信号处理问题研究

光栅传感器是一类精密传感器 ,在直线位移或角位移的测量中有广泛的应用。但在工业应用中 ,除各种电磁干扰外 ,还有微小机械振动产生的干扰以及温度误差等 ,使测量精度大大下降。本文提出了在后续处理电路和信号处理方法上解决这一问题 ,提高传感器精度、分辨率和抗干扰能力的综合方法 ,如分频、温度补偿、定时器飞读和计数脉冲确认机制等。在实际使用中发现 ,应用这些方法的测量系统的稳定性、抗干扰能力和精度等指标都得到提高。     

心墙坝浸润线简化计算方法

通过理论分析和数值计算,在考虑坝体与防渗墙的相对渗透系数关系的基础上,提出了估算心墙坝坝体浸润线的一种简化计算方法,给出了浸润线位置的拟合公式。以白鸭山水库大坝为例,将该简化方法与有限元法的计算结果进行对比,表明该简化方法合理、可行。这一简化计算方法可大大减少中小型水库大坝在进行除险加固方案比选时的计算工作量。     

基于ABAQUS 的南水北调高填方边坡稳定性分析

利用大型有限元软件 ABAQUS 建立了高填方渠段某一断面的二维有限元数值模型,根据有限元强度折减法的基本原理以及土体特性,对高填方渠道边坡的稳定性进行了分析,再利用有限元强度折减法的失稳判定依据确定了合理可行的边坡稳定安全系数。结果证明,有限元强度折减法所获得的临界滑动面结果与极限平衡法的结果几乎一致。可见,以特征点的位移突变性和塑性区的贯通性来分析边坡的临界破坏可以减少误差并得到合理唯一的边坡安全系数,因此是合理可行的。     

长江干流朱沱站- 大通站基流变化特征

基流是河川径流中相对稳定的径流组成部分, 基流分割在水资源、水环境和水安全的管理研究中都有着重要 的应用。为了探究沿长江干流的基流变化特征, 使用递归数字滤波法对长江干流7 个水文站进行基流分割研究。 结果表明, 各站基流指数在01 768~ 01 798 之间。对朱沱站- 大通站区间基流量贡献最大的区间是宜昌站- 螺山 站, 其次是朱沱站- 寸滩站, 最小的是万县站- 宜昌站。2000 年前后, 长江干流基流量出现明显的衰减变化。基流 量衰减最大的是宜昌站( 衰减率为81 82%) , 其次为万县站( 衰减率为81 79%) 。     

Dynamics of mental and physical capacities of Moscow's schoolchildren administered vitamins]

Mental and physical capacities were studied in schoolchildren aged 6-10, 11-13 and 14-17 years in the autumn-spring period during vitamin administration of "Undevitum". The six-month vitamin administration produced a positive effect on the functional state of the schoolchildren that was expressed in the improvement of their mental and physical capacity parameters.     

Airway responses in healthy and asthmatic subjects following exposure to low ambient air temperature

Agonist-activated Ca2+ entry is important in many biological responses such as secretion and cell growth(1,2). In nonexcitable cells which have no voltage-operated Ca2+ channels (VOCC), agonist-receptor interaction can trigger Ca2+ entry across the plasmalemma via several entry pathways(1-3) (Fig 1): (A) channels which are intrinsic structures of the receptor (receptor-operated channels), (B) channels which are coupled to receptors via a G-protein (G-protein-operated channels), (C) channels which are activated by some second messengers (second-messenger-operated channels), and (D) channels which open upon intracellular nonmitochondrial Ca2+ store depletion (Ca2+ release-activated channels) resulting from inositol 1, 4, 5-trisphosphate-induced Ca2+ release or inhibition of Ca2+ re-uptake (see next section). Ca2+ entry via the 4th type of channel, also known as "capacitative Ca2+ entry" (CCE)[4], has aroused much interest in the past decade because of its intriguing nature as retrograde signalling. In this brief review, we present the evidence for and the possible biochemical processes involved in CCE. We also discuss the use of 2 novel Ca2+ entry blockers: tetrandrine and SK&F 96365. Emphasis will be put on the human leukemic HL-60 cell line, a popular cell system for intracellular Ca2+ homeostasis studies and also a model the signal transduction of which we have been investigating during the past few years.