Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer

STUDY OBJECTIVE: To determine the impact of preoperative resting hypercapnia on patient outcome after bilateral lung volume reduction surgery (LVRS). METHODS: We prospectively examined morbidity, mortality, quality of life (QOL), and physiologic outcome, including spirometry, gas exchange, and exercise performance in 15 patients with severe emphysema and a resting PaCO2 of > 45 mm Hg (group 1), and compared the results with those from 31 patients with a PaCO2 of < 45 mm Hg (group 2). RESULTS: All preoperative physiologic and QOL indices were more impaired in the hypercapnic patients than in the eucapnic patients. The hypercapnic patients exhibited a lower preoperative FEV1, a lower diffusing capacity of the lung for carbon monoxide, a lower ratio of PaO2 to the fraction of inspired oxygen, a lower 6-min walk distance, and higher oxygen requirements. However, after surgery both groups exhibited improvements in FVC (group 1, p < 0.01; group 2, p < 0.001), FEV1 (group 1, p=0.04; group 2, p < 0.001), total lung capacity (TLC; group 1, p=0.02; group 2, p < 0.001), residual volume (RV; group 1, p=0.002; group 2, p < 0.001), RV/TLC ratio (group 1, p=0.03; group 2, p < 0.001), PaCO2 (group 1, p=0.002; group 2, p=0.02), 6-min walk distance (group 1, p=0.005; group 2, p < 0.001), oxygen consumption at peak exercise (group 1, p=0.02; group 2, p=0.02), total exercise time (group 1, p=0.02; group 2, p=0.02), and the perceived overall QOL scores (group 1, p=0.001; group 2, p < 0.001). However, because the magnitude of improvement was similar in both groups, and the hypercapnic group was more impaired, the spirometry, lung volumes, and 6-min walk distance remained significantly lower post-LVRS in the hypercapnic patients. There was no difference in mortality between the groups (p=0.9). CONCLUSIONS: Patients with moderate to severe resting hypercapnia exhibit significant improvements in spirometry, gas exchange, perceived QOL, and exercise performance after bilateral LVRS. The maximal achievable improvements in postoperative lung function are related to preoperative level of function; however, the magnitude of improvement can be expected to be similar to patients with lower resting PaCO2 levels. Patients should not be excluded from LVRS based solely on the presence of resting hypercapnia. The long-term benefit of LVRS in hypercapnic patient remains to be determined.     

网格技术在党校图书馆2．0中的运用

网格技术的出现，催生了图书馆2．0这种全新的信息和知识管理形态。使需要运用知识的人们，能够通过网格技术迅速的较为准确些找到自己所需要的知识点。网格技术使知识有了自我产生的可能。为了使知识有序生长。我们图书馆人面临的是难得的机遇和全新的挑战。本文试图对运用网格技术，建立知识推介系统，为党校的教学科研服务作一些探讨。     

Evidence for repression of IL-2 gene activation in anergic T cells

The induction of clonal anergy in a T cell inhibits IL-2 secretion because of the development of a proximal signal transduction defect. Fusion of anergic murine T cells to human Jurkat T leukemia cells and formation of heterokaryons failed to result in a complementation of this signaling defect and restoration of murine IL-2 mRNA inducibility. Instead, signal transduction to the human IL-2 gene became disrupted. Heterokaryons formed by the fusion of anergic murine T cells to normal murine T cells also failed to accumulate intracellular IL-2 protein in response to stimulation either with the combination of CD3 and CD28 mAbs or with ionomycin plus a protein kinase C-activating phorbol ester. The results argue against a loss-of-function signaling defect as the sole basis for clonal anergy induction and document the presence of a dominant-acting repressor molecule that inhibits signal transduction to the IL-2 gene within viable anergic T cells.     

一种具有延迟校准功能的可编程多相位时钟电路

基于延迟锁相环原理,提出了一种新型的具有延迟校准功能的可编程多相位时钟电路,能为工作在80MHz的电荷耦合器件信号处理器提供精度高达390ps的时序信号．将主时钟的单周期等分为32份,通过可编程相位组合电路,产生相位及占空比可调的信号,能满足不同电荷耦合器件所需的最优工作时序．传统的延迟锁相环结构随着延迟单元的增加,延迟单元之间不匹配愈加明显,导致输出相位偏离理想位置．引入延迟校准电路可以显著降低相位之间的误差,校准后的多相位时钟信号接入可编程相位组合器进行选择组合,产生所需的高精度时序信号．基于SMIC 0.18μm 3.3V CMOS工艺完成设计,在80MHz主时钟下的后仿真结果表明：电路可产生占空比范围为2％～98％的输出时钟,校准后的延迟误差小于5ps,边到边抖动为 1.14ps,有效地保证了相位精度．     

Molecular and thermal characteristics of acid-soluble collagen from orbicular batfish: effects of deep-sea water culturing

Acid-soluble collagen (ASC) was extracted from the skin and meat of orbicular batfish (Platax orbicularis) cultured in deep-sea water (DSW) and shallow-sea water (SSW). The fish cultured in deep-sea water contained higher collagen content (42.14 mg/g) in meat than that cultured in shallow-sea water (33.67 mg/g) (p<0.05). The yield of ASC was 35.72% (dry weight basis) from the skin of DSW cultured fish being higher than that of the SSW cultured fish (25.9%). The collagen of the orbicular batfish cultured in DSW showed higher water-holding capacity and lower thermal denaturation temperature than those from SSW. Orbicular batfish collagens constituted α1-chain, α2-chain and β-chain were characterized as type I collagen. The collagen helices of DSW-cultured orbicular batfish were less stable than those of SSW-cultured orbicular batfish, due to the lower imino acid content.     

基于联合神经网络的传感器故障诊断与重构

针对可能发生的传感器故障,设计出了一种基于联合神经网络的传感器容错系统.提出了一种改进型的径向基函数神经网络,有较强的容错能力.算法包括1个主网络和n个分散网络的联合神经网络结构,各神经网络均基于改进型径向基函数算法,根据一定的控制目标对系统中的传感器故障进行检测、识别和调节,达到了容错控制的目的.     

用气相反应法制备纳米WO3气敏材料

材料的制备是研制半导体气敏传感器的关键环节.用气相反应法,以纯钨丝为原料,制备了WO3粉末,又以此WO3粉末为基材,制作了NO2气敏传感元件.在性能测试中发现,该元件对低浓度(10-10)NO2灵敏,灵敏度可达10倍左右,而且响应迅速,响应时间为1.5 s.文中从材料的微观结构入手,对材料的敏感机理作了分析.     

薄壁圆筒谐振式液体密度传感器的设计

在对圆筒谐振子的数学模型计算和有限元分析的基础上,设计了一种新型的谐振式液体密度传感器.该传感器由双端固定的圆筒谐振子、自动增益和相位调节的测量控制电路、C8051F020单片机的信号处理系统组成,具有对压力变化不敏感和智能温度补偿的功能.实验结果表明,20℃时传感器系数为K0=-129.5668 kg/m3,K1=-0.253 5×106(kg/m3)/s,K2=0.623 9×1010 (kg/m3)/s2,在700～900 kg/m3的测量范围内,综合测量精度为0.1%.     

多光纤传感器数据融合测量表面误差的方法研究

提出了一种基于多光纤传感器数据融合测量表面粗糙度、平面度和平行度等误差的方法.研制了其测量实现系统;论述了光纤传感器测量表面粗糙度、平面度和平行度等误差的测量原理,以及其光电探测电路的设计;经实验表明该表面误差测量方法具有多误差同时快速测量的优点,为表面误差参数测量提供了新的思路和方法.