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41.
Malignant melanoma of the mucous membranes is rare and has a very poor prognosis. When localized in the nose, the tumor becomes apparent late in the course of the disease with nasal obstruction and epistaxis. Distant metastases are uncommon, but any organ of the body can be involved. A case of a malignant melanoma of the nasal mucosa with metastasis to the small intestine is presented, and the natural history of the metastatic disease is discussed. 相似文献
42.
EN Dychko VN Mirtovskaia GI Sirota OI Sukmanski? 《Canadian Metallurgical Quarterly》1981,81(4):524-527
Under observation there were 78 patients aged 41 to 70 years suffering from the glossalgia syndrome, as well as 25 clinically healthy subjects. An activation of the sympathoadrenal system was revealed in the patients. This was ascertained on the basis of the data on vanillylmandelic acid excretion with the urine. The excretion of that acid is known to be dependent on the intensity of the paraesthesias, the duration of the ailment and the character of concurrent visceral diseases. The results obtained are regarded as evidences of the participation of the vegetative nervous system in the mechanism of the glossalgia syndrome development. 相似文献
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A canonical form for controllable singular systems modulo restricted system equivalence is presented. The canonical form respects the decomposition of the singular system into a regular and an impulsive part. The construction is based on Popov's control canonical form and on the Jordan canonical form recently developed by Hinrichsen and Prätzel-Wolters. Continuity properties are analysed and the cellular partition of the orbit space induced by the canonical form is briefly discussed. 相似文献
46.
Dehong Huo Kai Cheng Frank Wardle 《International Journal of Machine Tools and Manufacture》2010,50(4):335-343
Ultraprecision machines with small footprints or micro-machines are highly desirable for micro-manufacturing high-precision micro-mechanical components. However, the development of the machines is still at the nascent stage by working on an individual machine basis and hence lacks generic scientific approach and design guidelines. Using computer models to predict the dynamic performance of ultraprecision machine tools can help manufacturers substantially reduce the lead time and cost of developing new machines. Furthermore, the machine dynamic performance depends not only upon the mechanical structure and components but also the control system and electronic drives. This paper proposed a holistic integrated dynamic design and modelling approach, which supports analysis and optimization of the overall machine dynamic performance at the early design stage. Based on the proposed approach the modelling and simulation process on a novel 5-axis bench-top ultraprecision micro-milling machine tool – UltraMill – is presented. The modelling and simulation cover the dynamics of the machine structure, moving components, control system and the machining process, and are used to predict the overall machine performance of two typical configurations. Preliminary machining trials have been carried out and provided the evidence of the approach being helpful to assure the machine performing right at the first setup. 相似文献
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Ian W Hamley Valeria Castelletto Nágila MPS Ricardo Maria EN Pinho Colin Booth David Attwood Zhuo Yang 《Polymer International》2007,56(1):88-92
Small‐angle X‐ray scattering was used to characterise aqueous micellar gels of triblock copolymers E137S18E137, E82S9E82, E76S5E76, E62P39E62, and of two mixtures: E137S18E137 and E62P39E62 (Mix 1) and E82S9E82 and E62P39E62 (Mix 2), each 50/50 wt%. E = oxyethylene, CH2CH2O; S = oxyphenylethylene, OCH2CH(C6H5); and P = oxypropylene, OCH2CH(CH3). Within the concentration and temperature ranges investigated (30–40 wt% copolymer, 20–80 °C), spherical micelles of copolymers E137S18E137, E82S9E82 and E62P39E62 packed into body‐centred cubic (BCC) structures. Gels of E76S5E76 were stable only at high concentrations and low temperatures, and a 70 wt% copolymer solution at T = 30 °C formed a hexagonal gel consistent with cylindrical micelles. It is likely that the mixed copolymers would form two distributions of micelles, and more complex structures were expected. However, gels of Mix 2 had well‐ordered BCC structures, while the less ordered gels of Mix 1 were also best characterised as BCC. Copyright © 2006 Society of Chemical Industry 相似文献
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C Astarie-Dequeker EN N'Diaye V Le Cabec MG Rittig J Prandi I Maridonneau-Parini 《Canadian Metallurgical Quarterly》1999,67(2):469-477
The mannose receptor (MR) is involved in the phagocytosis of pathogenic microorganisms. Here we investigated its role in the bactericidal functions of human monocyte-derived macrophages (MDMs), using (i) trimannoside-bovine serum albumin (BSA)-coated latex beads and zymosan as particulate ligands of the MR, and (ii) mannan and mannose-BSA as soluble ligands. We show that phagocytosis of mannosylated latex beads did not elicit the production of O2-. Zymosan, which is composed of alpha-mannan and beta-glucan, was internalized by the MR and a beta-glucan receptor, but the production of O2- was triggered only by phagocytosis through the beta-glucan receptor. Activation and translocation of Hck, a Src family tyrosine kinase located on lysosomes, has previously been used as a marker of fusion between lysosomes and phagosomes in human neutrophils. In MDMs, Hck was activated and recruited to phagosomes containing zymosan later than LAMP-1 and CD63. Phagosomes containing mannosylated latex beads fused with LAMP-1 and CD63 vesicles but not with the Hck compartment, and the kinase was not activated. We also demonstrate that the MR was unable to distinguish between nonpathogenic and pathogenic mycobacteria, as they were internalized at similar rates by this receptor, indicating that this route of entry cannot be considered as a differential determinant of the intracellular fate of mycobacteria. In conclusion, MR-dependent phagocytosis is coupled neither to the activation of NADPH oxidase nor to the maturation of phagosomes until fusion with the Hck compartment and therefore constitutes a safe portal of entry for microorganisms. 相似文献
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