Promise is Debt, Threat Another Matter: The Effect of Credibility on the Interpretation of Conditional Promises and Threats.

Evidence from reasoning tasks shows that promises and threats both tend to receive biconditional interpretations. They also both display high speaker control. On the face of it, the only difference seems to be the positive or negative signing of the consequent. In a promise, the speaker tries to persuade the hearer to do something by holding out the prospect of a particular reward; in a threat, the speaker tries to refrain the hearer from doing something by holding out the prospect of a particular punishment. This paper investigates the respects in which conditional promises and threats differ further by means of an inference task. The credibility of the consequent was manipulated in order to examine whether the acceptability ratings of inferences based on promises and on threats would be equally affected. The results of the inference task and an analysis of the reasons people give for their answers suggest that the credibility of promises is less affected by the use of excessive consequents than the credibility of threats. In other words, promise remains debt, whereas threat is another matter. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro

The calcium-dependent cell-cell adhesion molecule E-cadherin has been shown to counteract invasion of epithelial neoplastic cells. Using three monoclonal antibodies, we have demonstrated the presence of E-cadherin at the surface of human MCF-7/6 mammary carcinoma cells by indirect immunofluorescence coupled to flow cytometry and by immunocytochemistry. Nevertheless, MCF-7/6 cells failed to aggregate in a medium containing 1.25 mM CaCl2, and they were invasive after confrontation with embryonic chick heart fragments in organ culture. Treatment of MCF-7/6 cells with 0.5 microgram ml-1 insulin-like growth factor I (IGF-I) led to homotypic aggregation within 5 to 10 min and inhibited invasion in vitro during at least 8 days. The effect of IGF-I on cellular aggregation was insensitive to cycloheximide. However, monoclonal antibodies that interfered with the function of either the IGF-I receptor (alpha IR3) or E-cadherin (HECD-1, MB2) blocked the effect of IGF-I on aggregation. The effects of IGF-I on aggregation and on invasion could be mimicked by 1 microgram ml-1 insulin, but not by 0.5 microgram ml-1 IGF-II. The insulin effects were presumably not mediated by the IGF-I receptor, since they could not be blocked by an antibody against this receptor (alpha IR3). Our results indicate that IGF-I activates the invasion suppressor role of E-cadherin in MCF-7/6 cells.     

Coaxial curved instrumentation for minimal access surgery

New coaxial curved and bayonet instruments have been designed which permit controlled dissection and directional change of the functional tip, blunt dissection and lift retraction. The instruments are introduced into the peritoneal and thoracic cavities through flexible re-usable metal cannulae. The excellent ergonomic properties of the new instruments have been confirmed by their use in major laparoscopic and thoracoscopic operations. Coaxial instruments enhance the scope of minimal access surgery and have distinct advantages over the traditional straight instruments.     

Laboratory techniques for evaluating solid oxide fuel cells

The construction of a small solid oxide fuel cell laboratory is described in terms of required materials, measuring techniques and equipment design. Details of various electrode deposition techniques and ways of making contacts to the electrodes are also outlined.     

The effect of matrix microstructure on cyclic response and fatigue behavior of particle- reinforced 2219 aluminum: Part I. room temperature behavior

The low-cycle and high-cycle fatigue behavior and cyclic response of naturally aged and overaged 2219/TiC/15p and unreinforced 2219 Al were investigated using plastic strain-controlled and stress-controlled testing. In addition, the influence of grain size on the particle-reinforced materials was examined. In both reinforced and unreinforced materials, the naturally aged conditions were cyclically unstable, exhibiting an initial hardening behavior followed by an extended region of cyclic stability and ultimately a softening region. The overaged reinforced material was cyclically stable for the plastic strains examined, while the overaged unreinforced material exhibited cyclic hardening at plastic strains greater than 2.5 × 10⁻⁴. Decreasing grain size of particle-reinforced materials modestly increased the cyclic flow stress of both naturally aged and overaged materials. Reinforced and unreinforced materials exhibited similar fatigue life behaviors; however, the reinforced and unreinforced naturally aged materials had superior fatigue lives in comparison to the overaged materials. Grain size had no effect on the fatigue life behavior of the particle-reinforced materials. The fatigue lives were strongly influenced by the presence of clusters of TiC particles and exogenous Al₃Ti intermetallics. formerly Research Assistant with the Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109 This article is based on a presentation made in the symposium entitled “Creep and Fatigue in Metal Matrix Composites” at the 1994 TMS/ASM Spring meeting, held February 28–March 3, 1994 in San Francisco, California, under the auspices of the Joint TMS-SMD/ASM-MSD Composite Materials Committee.     

A European community source of reference materials for neutron metrology requirements

Recognizing the importance of an assured supply of reference materials of high purity for use as neutron dosimeters, the Monitor Materials subgroup of the European Working Group on Reactor Dosimetry collaborated with the Central Bureau for Nuclear Measurements, Geel, Belgium to establish a list of requirements.CBNM is organizing the availability and characterization of these materials in collaboration with specialist laboratories within the European Community. At present 12 activation and 6 fission dosimetry materials are being examined prior to certification and issue.This source of materials is expected to be of great use for reactor surveillance, interlaboratory comparisons, and other neutron metrology requirements.     

Very high-order microring resonator filters for WDM applications

High-order microring resonators having from 1 to 11 coupled cavities are demonstrated. These filters exhibit low loss, flat tops, and out-of-band rejection ratios that can exceed 80 dB. They achieve performance that is suitable for commercial applications.     

Structure of metal site in Cd-substituted His117Gly mutant of azurin with and without addition of imidazole derivatives

The present work uses 111mCd-perturbed angular correlations of gamma-rays (PAC) to investigate the structure of the metal site of the His117Gly mutant of Pseudomonas aeruginosa azurin in aqueous solution and the effect on the structure upon addition of the following exogenous ligands: imidazole, 4-methyl imidazole, 1-methyl imidazole, 2-methyl imidazole and histidine. The nuclear quadrupole interaction of cadmium bound to the mutant without addition of exogenous ligands shows a strong pH dependence with three different nuclear quadrupole interactions consistent with two pKa values at about 7.2 and 8.6 at 2 degrees C. Addition of the imidazole derivatives resulted in a significant change in the PAC spectrum showing that they coordinate. This is in accordance with observations by EPR for the same mutant with copper at the metal site [den Blaauwen, T. & Canters, G. W. (1993) J. Am. Chem. Soc. 115, 1121-1129]. However, whereas EPR and ultraviolet/visual absorption show that the characteristics of the wild-type copper protein are regained by addition of the imidazole derivatives with the exception of the possible bidentates (histidine and histamine), the comparison of the PAC results to model calculations shows that the cadmium ion must be fourfold coordinated in most cases, probably binding an additional water or hydroxide ligand. A fourfold coordination is in contrast to cadmium-substituted wild-type azurin where PAC data inferred a threefold coordination by a Cys and two His residues [Danielsen, E. Bauer, R., Hemmingsen, L., Andersen. M., Bjerrum, M. J., Butz, T., Tr?ger, W., Canters, G. W., Hoitink, C. W. G., Karlsson, G., Hansson, O. & Messerschmidt, A. (1995) J. Biol. Chem. 270, 573-580]