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961.
962.
963.
AT Lebre PP Prado ES Yonamine Z Rasslan JC Bonadia CA Lima 《Canadian Metallurgical Quarterly》1995,41(4):271-273
The fluoroquinolones have an established role in treatment of infection with aerobic gram negative rods. The increased importance of gram positive nosocomial infection and of acquired fluoroquinolone resistance has stimulated a search for new compounds with enhanced potency and spectrum. CP-99,219 is a novel compound in this class with enhanced activity against gram positive organisms. We have studied the activity of CP-99,219 relative to ciprofloxacin, fleroxacin, ofloxacin, and sparfloxacin using test panels of organisms with a high proportion of ciprofloxacin resistance. CP-99,219 is more potent than any of the other four compounds against both gram positive and gram negative bacteria. The activity of CP-99,219 against many bacteria resistant to the established agents, warrants further in vitro and clinical studies. 相似文献
964.
It is not simple to report research results to the people who participated in the research as subjects of study. Few evaluations have examined subjects' understanding of written research findings. In two recent studies of solvent exposure, subjects received brief summaries of the research. Before they were sent, the summaries were evaluated by research, health, and communication specialists as well as by representatives of the target audience. For one of the studies, interviews were conducted with subjects before and after they received the reports. Although the subjects said they understood the summary, their answers to questions about its content indicated otherwise. The results suggest that researchers not rely on subjects' self-assessments of their understanding but instead design methods to test subjects' knowledge directly. Those tests would be most valuable if applied in formative evaluations, when the opportunity exists to improve the research summaries. 相似文献
965.
DC Bauer WS Browner JA Cauley ES Orwoll JC Scott DM Black JL Tao SR Cummings 《Canadian Metallurgical Quarterly》1993,118(9):657-665
OBJECTIVE: To determine the factors associated with appendicular bone mass in older women. DESIGN: Cross-sectional analysis of baseline data collected for a multicenter, prospective study of osteoporotic fractures. SETTING: Four clinical centers in Baltimore, Maryland; Minneapolis, Minnesota; Portland, Oregon; and the Monongahela valley, Pennsylvania. PATIENTS: A total of 9704 ambulatory, nonblack women, ages 65 years or older, recruited from population-based listings. MEASUREMENTS: Demographic and historical information and anthropometric measurements were obtained from a baseline questionnaire, interview, and examination. Single-photon absorptiometry scans were obtained at three sites: the distal radius, midradius, and calcaneus. Multivariate associations with bone mass were first examined in a randomly selected half of the cohort (training group) and were then tested on the other half of the cohort (validation group). RESULTS: In order of decreasing strength of association, estrogen use, non-insulin-dependent diabetes, thiazide use, increased weight, greater muscle strength, later age at menopause, and greater height were independently associated with higher bone mass. Gastric surgery, age, history of maternal fracture, smoking, and caffeine intake were associated with lower bone mass (all P < 0.05). For example, we found that 2 or more years of estrogen use was associated with a 7.2% increase in distal radius bone mass, whereas gastrectomy was associated with an 8.2% decrease in bone mass. The associations between bone mass and dietary calcium intake and rheumatoid arthritis were inconsistent. Alcohol use, physical activity, use of calcium supplements, pregnancy, breast-feeding, parental nationality, and hair color were among the many variables not associated with bone mass. Multivariate models accounted for 20% to 35% of the total variance of bone mass. CONCLUSIONS: A large number of factors influence the bone mass of elderly women; however, age, weight, muscle strength, and estrogen use are the most important factors. 相似文献
966.
Hypertension has its roots in childhood. Electrocardiographic, echocardiographic, and exercise testing in young patients point to early abnormalities of cardiovascular status in children with early hypertensive disease. Altered morphology of the cardiovascular system and vascular reactivity is also seen in the hypertensive or prehypertensive child. Perhaps investigation and preventive tactics may be best applied to the pediatric population. 相似文献
967.
968.
A list of drugs considered to have a narrow therapeutic margin are discussed. These potentially toxic drugs will be reviewed, including recommended therapeutic ranges, when therapeutic levels should be obtained, and additional laboratory studies that may be required for patients on these medications who are preparing to undergo surgery. 相似文献
969.
970.
A Lerdo de Tejada A Hernández ES Lerdo de Tejada M Guzmán V Shor S Karchmer 《Canadian Metallurgical Quarterly》1976,41(3-4):95-99
The levels of plasma lipids and the values of the different electrophoretic fractions of lipoproteins were measured in cord blood of 300 new borns selected at random. The value found are expressed as me +/- S.D. (limits X +/-2s) and were the following: total cholesterol 80.4 +/- 17.5 (limits 45-115) mg./100 ml., LDL cholesterol (by precipitation) 33+/-11 (limits 11-55) mg./100 ml., betalipo-protein (by immunodifusion) 142.7+/-26.4 (limits 90-195) mg./100 ml. and triglycerides 35+/-13 (limits 9-61) mg./100 ml. The figures for the different electrophoretic fractions of lipoproteins were expressed in per cent of the total area and were the following: betalipoproteins 42.9+/-10.3 (limits 22-63%), prebetalipoproteins 3.09+/-2.79 (limits 0-8.6%) and alphalipoproteins 53.8 +/- 9.5 (limits 35-73%). The beta/alpha ratio was 0.91+/-0.33 (limits 0.25-1.6). 相似文献