Nonadiabatic pathways in the dissociative adsorption of simple molecules

Molecular beams and laser spectrometry have been used to study nonadiabatic processes in the interaction of molecules with well-characterized surfaces. The emission of exoelectrons and the formation of O⁻ ions in the interaction of O₂ molecules with a Cs(√3 x √3) structure on Ru(001) is studied as a function of translational energy, extending previously reported results. The interaction of O₂ with an Al(111) surface exhibits an abstraction channel, which is predominant at translational energies smaller than 0.5 eV. In the interaction of NO₂ with an Al(111) surface, the operation of an abstraction channel resulting in O(a) and NO(g) is observed. All three examples are interpreted to indicate the significance of early charge transfer channels in molecular dissociative adsorption processes. Delayed charge transfer may lead to nonadiabatic reaction routes in this scenario.     

Der Stand der Ausbildung von Studierenden im Umgang mit Sterbenden und dem Tod an medizinischen Fakultäten in Deutschland: eine explorative Studie von 1994/95

Ohne Zusammenfassung     

Throughput-Optimal Sequences for Cyclically Operated Plants

In this paper, we present a method to determine globally optimal schedules for cyclically operated plants where activities have to be scheduled on limited resources. In cyclic operation, a large number of entities is processed in an identical time scheme. For strictly cyclic operation, where the time offset between entities is also identical for all entities, the objective of maximizing throughput is equivalent to the minimization of the cycle time. The resulting scheduling problem is solved by deriving a mixed integer optimization problem from a discrete event model. The model includes timing constraints as well as open sequence decisions for the activities on the resources. In an extension, hierarchical nesting of cycles is considered, which often allows for schedules with improved throughput. The method is motivated by the application to high throughput screening plants, where a specific combination of requirements has to be obeyed (e.g. revisited resources, absence of buffers, or time window constraints).     

Description of the Sounding Rocket Experiment—SOURCE

A SOUnding Rocket Compere Experiment (SOURCE) is prepared for launch in spring 2008 and shall deliver approximately 360 s of microgravity time. The experiment is intended to partially fulfill the scientific objectives of the European Space Agency Microgravity Applications Program project AO-2004-111 (Convective boiling and condensation). One of the tasks of this experiment is the investigation of capillary dominated flow at a heated wall. The SOURCE experiment will also serve the needs of the COMPERE research group whose mandate is to investigate the behavior of propellant in spacecraft tanks. SOURCE is a benchmark type of experiment on fluid behavior in tanks to test hypotheses and numerical predictions (quantitative results on a tank scale). Several work packages have been distributed to the Center of Applied Space Technology and Microgravity (ZARM) to manage a part of the preparation of this experiment. Since ZARM acts also as a principal investigator, the subject of surface tension driven flows is one of the main topics. It includes the design of the experimental setup to study free surface behavior as well as the numerical predictions to quantify the heat transfer at a non-isothermal boundary condition in the absence of gravity.     

ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis

A disintegrin and metalloproteinase (ADAM) family proteins, acting as sheddases, are important factors in a number of pathologies, including cancer, and have been suggested as promising therapeutic targets. The study presented focuses on the involvement of ADAM10 and ADAM17 in retinoblastoma (RB), the most common malignant intraocular childhood tumor. A significant correlation between ADAM17 expression levels and RB laterality and RB staging was observed. Levels of ADAM10 or ADAM17 regulating miRNAs miR-145, -152, and -365 were significantly downregulated in RB cell lines, and reduced miR levels with simultaneously upregulated ADAM10 and ADAM17 expression were found in RB patients. The involvement of both ADAMs analyzed in ectodomain shedding of the neuronal cell adhesion molecule L1 (L1CAM), shown to induce pro-tumorigenic effects in RB, was confirmed. Lentiviral ADAM10 and ADAM17 single or ADAM10/17 double knockdown (KD) induced caspase-dependent apoptosis and reduced cell viability, proliferation, growth, and colony formation capacity of RB cells. Moreover, differential phosphorylation of the serine/threonine kinase AKT was observed following ADAM17 KD in RB cells. Chicken chorioallantoic membrane (CAM) assays revealed that ADAM17 and ADAM10/17 depletion decreases the tumorigenic and migration potential of RB cells in vivo. Thus, ADAMs are potential novel targets for future therapeutic RB approaches.     

Die Bestimmung von St?rke in Pektin- und Apfels?ften auf sedimentrischem Wege

Ohne Zusammenfassung     

Die Refraktometrie als Hilfsmittel zur Untersuchung von Fruchts?ften

Ohne ZusammenfassungMitteilung aus dem Betriebslaboratorium der Konservenfabrik Johns. Eckart in München.