Numerical modeling of fracture coalescence in a model rock material

The crack pattern, as well as crack initiation, -propagation and -coalescence observed in experiments on gypsum specimens with pre-existing fractures in uniaxial, biaxial, and tensile loading are satisfactorily predicted with the numerical model presented in this paper. This was achieved with a new stress-based crack initiation criterion which is incorporated in FROCK, a Hybridized Indirect Boundary Element method first developed by Chan et al. (1990). The basic formulation of FROCK is described, and the code verified for both open and closed pre-existing fractures either with only friction or with friction and cohesion. The new initiation criterion requires only three material properties: σ_crit, the critical strength of the material in tension; τ_crit, the critical strength of the material in shear; r₀, the size of the plastic zone. The three parameters can be determined with the results from only one test. Predictions using this model are compared with experiments on gypsum specimens with pre-existing fractures loaded in uniaxial and biaxial compression performed by the authors. Specifically, wing crack and shear crack initiation, crack propagation, coalescence stress and -type as well as the crack pattern up to coalescence can be modeled. The model can also duplicate experimental results in compression and tension obtained by other researchers. These results show that stress-based criteria can be effectively used in modeling crack initiation and crack coalescence. This revised version was published online in August 2006 with corrections to the Cover Date.     

Bizarre imagery as an effective memory aid: The importance of distinctiveness.

Five experiments with 304 undergraduates investigated the effects of imagery type (bizarre or common) on memory of word triplets. In Exp I bizarre imagery increased recall when imagery type was manipulated in a within-list design but not when imagery type was manipulated in a between-list design. Results of Exp II show that this effect occurred with imagery processing instructions and not with semantic processing instructions. Exp III indicated that bizarre imagery facilitated recall in a within-list design for both self-paced and experimenter-paced presentations of the stimuli, and Exp IV, the pattern of effects of bizarre imagery on memory (in a within-list design) did not parallel the effects of presentation rate on memory. Data from Exps I through IV are inconsistent with an attentional explanation of bizarre imagery effects. In Exp V, when several types of additional learning were interpolated between initial imaginal processing and testing, bizarre imagery produced better recall with a between-list manipulation, but only when the additional learning involved common imagery. In addition to delineating the conditions under which bizarre imagery improves recall, overall findings suggest that distinctiveness may underlie the bizarreness effect. (29 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Multiple Processes in Prospective Memory Retrieval: Factors Determining Monitoring Versus Spontaneous Retrieval.

Theoretically, prospective memory retrieval can be accomplished either by controlled monitoring of the environment for a target event or by a more reflexive process that spontaneously responds to the presence of a target event. These views were evaluated in Experiments 1-4 by examining whether performing a prospective memory task produced costs on the speed of performing the ongoing task. In Experiment 5, the authors directly tested for the existence of spontaneous retrieval. The results supported the multiprocess theory (M. A. McDaniel & G. O. Einstein, 2000) predictions that (a) spontaneous retrieval can occur and can support good prospective memory and (b) depending on task demands and individual differences, people rely to different degrees on monitoring versus spontaneous retrieval for prospective remembering. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma

Uterine leiomyosarcoma (uLMS) is a rare and aggressive cancer with few effective therapeutics. The Notch signaling pathway is evolutionarily conserved with oncogenic properties, but it has not been well studied in uLMS. The purpose of our study was to determine expression of Notch family genes and proteins and to investigate the therapeutic effect of γ-secretase inhibitors (GSIs), indirect inhibitors of Notch signaling, in uLMS. We determined expression of Notch genes and proteins in benign uterine smooth muscle tissue, fibroids, and uLMS samples by immunostaining and in two uLMS cell lines, SK-UT-1B (uterine primary) and SK-LMS-1 (vulvar metastasis) by RT-PCR, Western blot and immunostaining. We exposed our cell lines to GSIs, DAPT and MK-0752, and measured expression of HES1, a downstream effector of Notch. Notch proteins were differentially expressed in uLMS. Expression of NOTCH3 and NOTCH4 was higher in uLMS samples than in benign uterine smooth muscle and fibroids. Expression of NOTCH4 was higher in SK-LMS-1 compared to SK-UT-1B. Exposure of SK-UT-1B and SK-LMS-1 to DAPT and MK-0752 decreased expression of HES1 and decreased uLMS cell viability in a dose- and time-dependent manner that was unique to each GSI. Our findings suggest that GSIs are potential therapeutics for uLMS, albeit with limited efficacy.     

Autonomous mobile robot navigation and learning

Research focused on the development and experimental validation of intelligent control techniques for autonomous mobile robots able to plan and perform a variety of assigned tasks in unstructured environments is presented. In particular, an autonomous mobile robot, HERMIES-IIB intelligence experiment series, is described. It is a self-powered, wheel-driven platform containing an onboard 16-node Ncube hypercube parallel processor interfaced to effectors and sensors through a VME-based system containing a Motorola 68020 processor, a phased sonar array, dual manipulator arms, and multiple cameras. Research on navigation and learning is examined     

Systematic evaluation of cracking behavior in specimens containing single flaws under uniaxial compression

This paper presents the results of an experimental study in which molded gypsum and Carrara Marble specimens containing a pre-existing flaw were tested in uniaxial compression. The main purpose of this study was to observe and characterize the cracks that emanate from a single pre-existing flaw. Seven different crack types were identified based on their geometry and propagation mechanism (tensile/shear). Specifically, they include three types of tensile cracks, three types of shear cracks, and one type of mixed tensile–shear crack. In addition to the geometry and mechanism, it was also possible to determine the temporal sequence of different crack types. These observations form the basis for a re-evaluation of cracking processes reported in the literature. It is possible to apply the classification obtained in the present research to previously conducted experiments by others. This eliminates much of the confusion that has existed when comparing different research results.     

Comparison of Reticular and Rectal Core Body Temperatures in Lactating Dairy Cows

The Phase IV Cattle Temperature Monitoring System (CTMS; Phase IV Engineering Inc., Boulder, CO) marketed by MaGiiX (MaGiiX Inc., Post Falls, ID) uses a passive bolus equipped with a temperature sensor, a panel reader placed at a parlor entrance or exit to query the bolus, and a software package to collect, analyze, and view data. The biologically inert bolus resides in the cow's reticulum and is queried each time the cow passes the reader. Reticular temperature (RETT) and rectal temperature (RECT) were recorded simultaneously in the milking parlor exit lane in 4 consecutive milkings in each of 4 seasons, totaling 16 measurements per cow. The RETT were obtained by using the phase IV CTMS, whereas the RECT were obtained manually with a GLA M750 thermometer (GLA Agricultural Electronics, San Luis Obispo, CA). Data were edited to remove RETT likely to have been affected by a recent drinking bout. For the 2,042 observations used in analyses, means (±SD) were 39.28 (±0.41), 38.83 (±0.36), and 0.45 (±0.33) for RETT, RECT, and the difference between RETT and RECT, respectively. The RETT and RECT were strongly correlated (r = 0.645). The relationship between RETT and RECT varied by season, milking, housing system, and parity. Because dairy producers and veterinarians are accustomed to viewing rectal temperatures, equations to adjust reticular temperatures to a rectal-based scale may increase the utility of the phase IV CTMS. The resulting conversion equations were RECT = 19.23 + 0.496(RETT) for the a.m. milking and RECT = 15.88 + 0.587(RETT) for the p.m. milking.