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51.
Chiara Agrati Alessandra Sacchi Eleonora Tartaglia Alessandra Vergori Roberta Gagliardini Alessandra Scarabello Michele Bibas 《International journal of molecular sciences》2021,22(15)
In severe COVID-19, which is characterized by blood clots and neutrophil-platelet aggregates in the circulating blood and different tissues, an increased incidence of cardiovascular complications and venous thrombotic events has been reported. The inflammatory storm that characterizes severe infections may act as a driver capable of profoundly disrupting the complex interplay between platelets, endothelium, and leukocytes, thus contributing to the definition of COVID-19-associated coagulopathy. In this frame, P-selectin represents a key molecule expressed on endothelial cells and on activated platelets, and contributes to endothelial activation, leucocyte recruitment, rolling, and tissue migration. Briefly, we describe the current state of knowledge about P-selectin involvement in COVID-19 pathogenesis, its possible use as a severity marker and as a target for host-directed therapeutic intervention. 相似文献
52.
Maral Mahdad Chiara Eleonora De Marco Andrea Piccaluga Alberto Di Minin 《Industry and innovation》2020,27(3):264-284
ABSTRACTThis paper focuses on how companies deploy structural properties of adaptive capacity (multiplexity, redundancy and loose coupling) to cope with the phenomenon of internal challenges of Open Innovation (OI) implementation, i.e. organisational and cultural changes. We developed a single case study, which offered significant findings. First, the multiplexity of relationships in OI settings helps to face the challenges of organisational and cultural changes by triggering trust formation and interaction. Second, redundancy has twofold elements: institutional logics redundancy triggers cultural change challenges which can be overcome through management practices and communications; task redundancy facilitates knowledge sharing and collaboration, thus helping to deal with organisational change challenges. Finally, loose coupling in OI settings facilitates social interconnectedness among members through management practices, helping to face organisational and cultural change challenges. We provide managerial and theoretical implication to deal with the challenges of OI in relation to both organisational and cultural changes. 相似文献
53.
Diana Boraschi Andi Alijagic Manon Auguste Francesco Barbero Eleonora Ferrari Szabolcs Hernadi Craig Mayall Sara Michelini Natividad I. Navarro Pacheco Alessandra Prinelli Elmer Swart Benjamin J. Swartzwelter Neus G. Bastús Laura Canesi Damjana Drobne Albert Duschl Marie‐Ann Ewart Jutta Horejs‐Hoeck Paola Italiani Birgit Kemmerling Peter Kille Petra Prochazkova Victor F. Puntes David J. Spurgeon Claus Svendsen Colin J. Wilde Annalisa Pinsino 《Small (Weinheim an der Bergstrasse, Germany)》2020,16(21)
The interaction of a living organism with external foreign agents is a central issue for its survival and adaptation to the environment. Nanosafety should be considered within this perspective, and it should be examined that how different organisms interact with engineered nanomaterials (NM) by either mounting a defensive response or by physiologically adapting to them. Herein, the interaction of NM with one of the major biological systems deputed to recognition of and response to foreign challenges, i.e., the immune system, is specifically addressed. The main focus is innate immunity, the only type of immunity in plants, invertebrates, and lower vertebrates, and that coexists with adaptive immunity in higher vertebrates. Because of their presence in the majority of eukaryotic living organisms, innate immune responses can be viewed in a comparative context. In the majority of cases, the interaction of NM with living organisms results in innate immune reactions that eliminate the possible danger with mechanisms that do not lead to damage. While in some cases such interaction may lead to pathological consequences, in some other cases beneficial effects can be identified. 相似文献
54.
Anna Maria Piras Ylenia Zambito Susi Burgalassi Daniela Monti Silvia Tampucci Eleonora Terreni Angela Fabiano Federica Balzano Gloria Uccello-Barretta Patrizia Chetoni 《Journal of materials science. Materials in medicine》2018,29(4):42
The ocular bioavailability of lipophilic drugs, such as dexamethasone, depends on both drug water solubility and mucoadhesion/permeation. Cyclodextrins and chitosan are frequently employed to either improve drug solubility or prolong drug contact onto mucosae, respectively. Although the covalent conjugation of cyclodextrin and chitosan brings to mucoadhesive drug complexes, their water solubility is restricted to acidic pHs. This paper describes a straightforward grafting of methyl-β-cyclodextrin (MCD) on quaternary ammonium chitosan (QA-Ch60), mediated by hexamethylene diisocyanate. The resulting product is a water-soluble chitosan derivative, having a 10-atom long spacer between the quaternized chitosan and the cyclodextrin. The derivative is capable of complexing the model drug dexamethasone and stable complexes were also observed for the lyophilized products. Furthermore, the conjugate preserves the mucoadhesive properties typical of quaternized chitosan and its safety as solubilizing excipient for ophthalmic applications was preliminary assessed by in vitro cytotoxicity evaluations. Taken as a whole, the observed features appear promising for future processing of the developed product into 3D solid forms, such as controlled drug delivery systems, films or drug eluting medical devices. 相似文献
55.
Brunella Parodi Eleonora Russo Sara Baldassari Guendalina Zuccari Sara Pastorino Mengying Yan 《Drug development and industrial pharmacy》2017,43(6):917-924
Objective: The aim of this work was the development of mucoadhesive sublingual films, prepared using a casting method, for the administration of oxycodone.Materials and methods: A solvent casting method was employed to prepare the mucoadhesive films. A calibrated pipette was used to deposit single aliquots of different polymeric solutions on a polystyrene plate lid. Among the various tested polymers, hydroxypropylcellulose at low and medium molecular weight (HPC) and pectin at two different degrees of esterification (PC) were chosen for preparing solutions with good casting properties, capable of producing films suitable for mucosal application.Results and discussion: The obtained films showed excellent drug content uniformity and stability and rapid drug release, which, at 8?min, ranged from 60% to 80%. All films presented satisfactory mucoadhesive and mechanical properties, also confirmed by a test on healthy volunteers, who did not experience irritation or mucosa damages. Pectin films based on pectin at lower degrees of esterification have been further evaluated to study the influence of two different amounts of drug on the physicochemical properties of the formulation. A slight reduction in elasticity has been observed in films containing a higher drug dose; nevertheless, the formulation maintained satisfactory flexibility and resistance to elongation.Conclusions: HPC and PC sublingual films, obtained by a simple casting method, could be proposed to realize personalized hospital pharmacy preparations on a small scale. 相似文献
56.
Integration of biofuels intermediates production and nutrients recycling in the processing of a marine algae 总被引:1,自引:0,他引:1 下载免费PDF全文
Ali Teymouri Sandeep Kumar Elena Barbera Eleonora Sforza Alberto Bertucco Tomas Morosinotto 《American Institute of Chemical Engineers》2017,63(5):1494-1502
The cost‐effective production of liquid biofuels from microalgae is limited by several factors such as recovery of the lipid fractions as well as nutrients management. Flash hydrolysis, a rapid hydrothermal process, has been successfully applied to fractionate the microalgal biomass into solid biofuels intermediates while recovering a large amount of the nutrients in the aqueous phase (hydrolyzate) in a continuous flow reactor. The aim of the work is to enhance the quality of a high‐ash containing marine algae Nannochloropsis gaditana as biofuel feedstock while recycling nutrients directly for algae cultivation. Characterization of products demonstrated an increase in extractable lipids from 33.5 to 65.5 wt % (dry basis) while retaining the same fatty acid methyl ester profile, in addition to diminution of more than 70 wt % of ash compared to raw microalgae. Moreover, the hydrolyzate was directly used to grow a microalga of the same genus. © 2016 American Institute of Chemical Engineers AIChE J, 63: 1494–1502, 2017 相似文献
57.
Carolina Mariana Nunes Rafael Pissinatti Eleonora Vieira dos Santos Roberto Gonçalves Junqueira Scheilla Vitorino Carvalho de Souza 《Food Analytical Methods》2018,11(3):808-823
The presence of dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in food is an important consideration for food safety, especially in fish matrices that are susceptible to bioaccumulation of those compounds from marine environments. In this context, the production of a reference material (RM) for this analytical scope is of great importance for ensuring the reliability of the results generated by monitoring programs. A lyophilized material was produced by spiking tilapia fillets with 29 compounds, and the material was evaluated based on the potential for using it as a certified reference material (CRM) or in proficiency testing (PT) schemes. A pilot experiment was performed to evaluate the incorporation of the analytes in tilapia fillets using standards prepared in nonane and in fish oil. The process yield was approximately 16% for both conditions, but higher mean recoveries were achieved with fish oil. The tilapia fillets were processed, and a portion of this bulk was spiked and then homogenized. The spiked and unspiked portions were frozen prior to lyophilization. Each freeze-dried portion was homogenized and sieved, and then, the portions were mixed, packed, and stored under refrigeration. The material was considered homogeneous for all analytes based on the criteria established for PT. Of the tested analytes, 27 were found to be stable in the short-term design (p > 0.05) when the material was kept at 45 ± 2 °C for 9 days. Long-term stability was evaluated at 2, 4, 6, and 8 months, and 22 of the analytes were found to be stable through up to 4 months of storage based on the criteria defined in references related to both the production of CRM and PT. The contributions of the homogeneity and stability in the short- and long-term uncertainties were estimated and indicated the adequacy of the material for use as a reference for trueness experiments. 相似文献
58.
Mariangela Scalise Fabiola Marino Luca Salerno Eleonora Cianflone Claudia Molinaro Nadia Salerno Antonella De Angelis Giuseppe Viglietto Konrad Urbanek Daniele Torella 《International journal of molecular sciences》2021,22(24)
Organoids are tiny, self-organized, three-dimensional tissue cultures that are derived from the differentiation of stem cells. The growing interest in the use of organoids arises from their ability to mimic the biology and physiology of specific tissue structures in vitro. Organoids indeed represent promising systems for the in vitro modeling of tissue morphogenesis and organogenesis, regenerative medicine and tissue engineering, drug therapy testing, toxicology screening, and disease modeling. Although 2D cell cultures have been used for more than 50 years, even for their simplicity and low-cost maintenance, recent years have witnessed a steep rise in the availability of organoid model systems. Exploiting the ability of cells to re-aggregate and reconstruct the original architecture of an organ makes it possible to overcome many limitations of 2D cell culture systems. In vitro replication of the cellular micro-environment of a specific tissue leads to reproducing the molecular, biochemical, and biomechanical mechanisms that directly influence cell behavior and fate within that specific tissue. Lineage-specific self-organizing organoids have now been generated for many organs. Currently, growing cardiac organoid (cardioids) from pluripotent stem cells and cardiac stem/progenitor cells remains an open challenge due to the complexity of the spreading, differentiation, and migration of cardiac muscle and vascular layers. Here, we summarize the evolution of biological model systems from the generation of 2D spheroids to 3D organoids by focusing on the generation of cardioids based on the currently available laboratory technologies and outline their high potential for cardiovascular research. 相似文献
59.
Eleonora Persoons Sara Kerselaers Thomas Voets Joris Vriens Katharina Held 《International journal of molecular sciences》2021,22(24)
Sex hormone steroidal drugs were reported to have modulating actions on the ion channel TRPM3. Pregnenolone sulphate (PS) presents the most potent known endogenous chemical agonist of TRPM3 and affects several gating modes of the channel. These includes a synergistic action of PS and high temperatures on channel opening and the PS-induced opening of a noncanonical pore in the presence of other TRPM3 modulators. Moreover, human TRPM3 variants associated with neurodevelopmental disease exhibit an increased sensitivity for PS. However, other steroidal sex hormones were reported to influence TRPM3 functions with activating or inhibiting capacity. Here, we aimed to answer how DHEAS, estradiol, progesterone and testosterone act on the various modes of TRPM3 function in the wild-type channel and two-channel variants associated with human disease. By means of calcium imaging and whole-cell patch clamp experiments, we revealed that all four drugs are weak TRPM3 agonists that share a common steroidal interaction site. Furthermore, they exhibit increased activity on TRPM3 at physiological temperatures and in channels that carry disease-associated mutations. Finally, all steroids are able to open the noncanonical pore in wild-type and DHEAS also in mutant TRPM3. Collectively, our data provide new valuable insights in TRPM3 gating, structure-function relationships and ligand sensitivity. 相似文献
60.
Eleonora Catsigeras 《Dynamical Systems: An International Journal》2014,29(1):78-97
We define a minimal α-observability of Ilyashenko’s statistical attractors. We prove that the space is always full Lebesgue decomposable into pairwise disjoint sets that are Lebesgue-bounded away from zero and included in the basins of a finite family of minimal α-observable statistical attractors. Among other examples, we analyse the Bowen homeomorphisms with non-robust topological heteroclinic cycles. We prove the existence of three types of statistical behaviours for these examples. 相似文献