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81.
Gian Carlo Alfonso Luigi Olivero Antonio Turturro Enrico Pedemonte 《Polymer International》1973,5(2):141-154
The self-seeding crystallisation technique is applied to a dilute solution of polyethylene in xylene containing, in suspension, foreign particles; data concerning some pigments usually employed for colouring the plastics are reported. It is shown that this method allows easy demonstration of the interactions existing between the dissolved polymer and the pigment; at the same time, it is possible to study the morphology which is evolved as a consequence of these interactions under particularly simple conditions as only a small amount of polymer crystallises on the pigment particles. The behaviour of several pigments is consistent with the results obtained by crystallising the bulk polyethylene coloured with the same pigments. Some unusual morphologies are made evident. 相似文献
82.
A mammalian genetic system to screen for small molecules capable of disrupting protein-protein interactions 总被引:2,自引:0,他引:2
Zhao HF Kiyota T Chowdhury S Purisima E Banville D Konishi Y Shen SH 《Analytical chemistry》2004,76(10):2922-2927
A mammalian two-hybrid system was developed for high-throughput screening of compounds that disrupt specific protein-protein interactions. The existing mammalian systems are unsatisfactory for drug screening due to nonregulated expression of interacting proteins. To construct a tightly regulated system, the tetracycline repressor was fused with the inhibitory KRAB domain as a suppressor. The binding of the suppressor to the tet operator entirely blocked expression of two interacting proteins. When both the inducer doxycycline and drugs were added to the culture, the reporter gene was either activated by interaction of the paired proteins with ineffective drugs or remained silent due to disruption of the protein interactions by the effective drugs. We demonstrate that interactions of the type I receptor for TGFbeta with FKBP12 and the epidermal growth factor receptor (EGFR) with p85 are effectively disrupted by FK506 and EGFR kinase inhibitor AG1478, respectively. The power of this system for drug screening was further demonstrated by rapid identification of inhibitors from a druglike library for the receptor kinases. 相似文献
83.
Selective refinement queries for volume visualization of unstructured tetrahedral meshes 总被引:1,自引:0,他引:1
Cignoni P De Floriani L Magillo P Puppo E Scopigno R 《IEEE transactions on visualization and computer graphics》2004,10(1):29-45
We address the problem of the efficient visualization of large irregular volume data sets by exploiting a multiresolution model based on tetrahedral meshes. Multiresolution models, also called Level-Of-Detail (LOD) models, allow encoding the whole data set at a virtually continuous range of different resolutions. We have identified a set of queries for extracting meshes at variable resolution from a multiresolution model, based on field values, domain location, or opacity of the transfer function. Such queries allow trading off between resolution and speed in visualization. We define a new compact data structure for encoding a multiresolution tetrahedral mesh built through edge collapses to support selective refinement efficiently and show that such a structure has a storage cost from 3 to 5.5 times lower than standard data structures used for tetrahedral meshes. The data structures and variable resolution queries have been implemented together with state-of-the art visualization techniques in a system for the interactive visualization of three-dimensional scalar fields defined on tetrahedral meshes. Experimental results show that selective refinement queries can support interactive visualization of large data sets. 相似文献
84.
Giuseppe?Della PennaEmail author Benedetto?Intrigila Igor?Melatti Enrico?Tronci Marisa?Venturini Zilli 《International Journal on Software Tools for Technology Transfer (STTT)》2004,6(4):320-341
In this paper we show that statistical properties of the transition graph of a system to be verified can be exploited to improve memory or time performances of verification algorithms.We show experimentally that protocols exhibit transition locality. That is, with respect to levels of a breadth-first state space exploration, state transitions tend to be between states belonging to close levels of the transition graph. We support our claim by measuring transition locality for the set of protocols included in the Mur verifier distribution .We present a cache-based verification algorithm that exploits transition locality to decrease memory usage and a disk-based verification algorithm that exploits transition locality to decrease disk read accesses, thus reducing the time overhead due to disk usage. Both algorithms have been implemented within the Mur verifier.Our experimental results show that our cache-based algorithm can typically save more than 40% of memory with an average time penalty of about 50% when using (Mur) bit compression and 100% when using bit compression and hash compaction, whereas our disk-based verification algorithm is typically more than ten times faster than a previously proposed disk-based verification algorithm and, even when using 10% of the memory needed to complete verification, it is only between 40 and 530% (300% on average) slower than (RAM) Mur with enough memory to complete the verification task at hand. Using just 300 MB of memory our disk-based Mur was able to complete verification of a protocol with about 109 reachable states. This would require more than 5 GB of memory using standard Mur . 相似文献
85.
86.
We develop an algorithm to compute asset allocations for Kahneman and Tversky’s (Econometrica, 47(2), 263–291, 1979) prospect theory. An application to benchmark data as in Fama and French (Journal of Financial Economics, 47(2), 427–465, 1992) shows that the equity premium puzzle is resolved for parameter values similar to those found in the laboratory
experiments of Kahneman and Tversky (Econometrica, 47(2), 263–291, 1979). While previous studies like Benartzi and Thaler (The Quarterly Journal of Economics, 110(1), 73–92, 1995), Barberis, Huang and Santos (The Quarterly Journal of Economics, 116(1), 1–53, 2001), and Grüne and Semmler (Asset prices and loss aversion, Germany, Mimeo Bielefeld University, 2005) focussed on dynamic aspects of asset pricing but only used loss aversion to explain
the equity premium puzzle our paper explains the unconditional moments of asset pricing by a static two-period optimization
problem. However, we incorporate asymmetric risk aversion. Our approach allows reducing the degree of loss aversion from 2.353
to 2.25, which is the value found by Tversky and Kahneman (Journal of Risk and Uncertainty, 5, 297–323, 1992) while increasing the risk aversion from 1 to 0.894, which is a slightly higher value than the 0.88 found
by Tversky and Kahneman (Journal of Risk and Uncertainty, 5, 297–323, 1992). The equivalence of these parameter settings is robust to incorporating the size and the value portfolios
of Fama and French (Journal of Finance, 47(2), 427–465, 1992). However, the optimal prospect theory portfolios found on this larger set of assets differ drastically
from the optimal mean-variance portfolio. 相似文献
87.
A crack is steadily running in an elastic isotropic fluid-saturated porous solid at an intersonic constant speed c. The crack tip speeds of interest are bounded below by the slower between the slow longitudinal wave-speed and the shear
wave-speed, and above by the fast longitudinal wave-speed. Biot’s theory of poroelasticity with inertia forces governs the
motion of the mixture. The poroelastic moduli depend on the porosity, and the complete range of porosities n ∈ [0, 1] is investigated. Solids are obtained as the limit case n = 0, and the continuity of the energy release rate as the porosity vanishes is addressed. Three characteristic regions in
the plane (n, c) are delineated, depending on the relative order of the body wave-speeds. Mode II loading conditions are considered, with
a permeable crack surface. Cracks with and without process zones are envisaged. In each region, the analytical solution to
a Riemann–Hilbert problem provides the stress, pore pressure and velocity fields near the tip of the crack. For subsonic propagation,
the asymptotic crack tip fields are known to be continuous in the body [Loret and Radi (2001) J Mech Phys Solids 49(5):995–1020].
In contrast, for intersonic crack propagation without a process zone, the asymptotic stress and pore pressure might display
a discontinuity across two or four symmetric rays emanating from the moving crack tip. Under Mode II loading condition, the
singularity exponent for energetically admissible tip speeds turns out to be weaker than 1/2, except at a special point and
along special curves of the (n, c)-plane. The introduction of a finite length process zone is required so that 1. the energy release rate at the crack tip
is strictly positive and finite; 2. the relative sliding of the crack surfaces has the same direction as the applied loading.
The presence of the process zone is shown to wipe out possible first order discontinuities. 相似文献
88.
Theera Anukunprasert Chintana Saiwan Elisabetta Di Bartolomeo Enrico Traversa 《Journal of Electroceramics》2007,18(3-4):295-303
Nanostructured powders of Nb-doped TiO2 (TN) and SnO2 mixed with Nb-doped TiO2 in two different atomic ratios—10 to 1 (TSN 101) and 1 to 1 (TSN 11)—were synthesized using the reverse micelle microemulsion
of a nonionic surfactant (brine solution/1-hexanol/Triton X-100/cyclohexane). The powders were characterized by transmission
electron microscopy (TEM) and X-ray diffraction (XRD). Thick films were fabricated for gas sensors and characterized by XRD
analysis and field emission scanning electron microscopy (FE-SEM). The effects of the film morphology and firing temperature
in the range 650–850 °C on CO sensitivity were studied. The best gas response, expressed as the ratio between the resistance
in air and the resistance under gas exposure (R
air/R
gas), was measured for TSN 11 at 11 for 1,000 ppm CO exposure. All types of sensors showed good thermal stability. The electrochemical
impedance spectroscopy (EIS) measurements were performed in different gas atmospheres (air, O2, CO and NO2) to better understand the electrical properties of the nanostructured mixed metal oxides. 相似文献
89.
Design of an enhanced access point to optimize TCP performance in Wi-Fi hotspot networks 总被引:1,自引:0,他引:1
In the last years, the number of Wi-Fi hotspots at public venues has undergone a substantial growth, promoting the WLAN technologies
as the ubiquitous solution to provide high-speed wireless connectivity in public areas. However, the adoption of a random
access CSMA-based paradigm for the 802.11 MAC protocol makes difficult to ensure high throughput and a fair allocation of
radio resources in 802.11-based WLANs. In this paper we evaluate extensively via simulations the interaction between the flow
control mechanisms implemented at the TCP layer and the contention avoidance techniques used at the 802.11 MAC layer. We conducted
our study considering initially M wireless stations performing downloads from the Internet. From our results, we observed that the TCP downlink throughput
is not limited by the collision events, but by the inability of the MAC protocol to assign a higher chance of accessing the
channel to the base station. We propose a simple and easy to implement modification of the base station’s behavior with the
purpose of increasing the TCP throughput reducing useless MAC protocol overheads. With our scheme, the base station is allowed
to transmit periodically bursts of data frames towards the mobile hosts. We design a resource allocation protocol aimed at
maximizing the success probability of the uplink transmissions by dynamically adapting the burst length to the collision probability
estimated by the base station. By its design, our scheme is also beneficial to achieve a fairer allocation of the channel
bandwidth among the downlink and uplink flows, and among TCP and UDP flows. Simulation results confirm both the improvement
in the TCP downlink throughput and the reduction of system unfairness. 相似文献
90.
A support vector machine (SVM) approach to the classification of transients in nuclear power plants is presented. SVM is a machine-learning algorithm that has been successfully used in pattern recognition for cluster analysis. In the present work, single- and multiclass SVM are combined into a hierarchical structure for distinguishing among transients in nuclear systems on the basis of measured data. An example of application of the approach is presented with respect to the classification of anomalies and malfunctions occurring in the feedwater system of a boiling water reactor. The data used in the example are provided by the HAMBO simulator of the Halden Reactor Project. 相似文献