When shoes become hammers: Goal-derived categorization training enhances problem-solving performance.

Problem-solving theories have not examined how solvers navigate their knowledge to interpret problem situations or to plan strategies toward goals. In this article, the author argues that success in problem solving depends on the solver's ability to construct goal-derived categories, namely categories that are formed ad hoc to serve goals during the instantiation of problem frames. Experiment 1 (N = 140) showed improved problem-solving performance after training to construct goal-derived categories. Experiment 2 (N = 80) demonstrated that effects of training in category construction can be obtained without participants being explicitly informed regarding the relevance of training to problem solving. These studies suggest that problem solving is a dynamic expression of goal-directed cognition and provide evidence for the involvement of categorization in problem-solving processes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Distance-based assessment of open country Quiet Areas in Greece

The need to preserve natural quietness, as a resourceful land protection strategy, has increased with the need to implement the EU's Environmental Noise Directive (END, 2002/49/EC) at a national level. We implemented distance-based criteria with view to defining potential Quiet Areas (QAs) in open country of Greece.Residential areas, industrial sites and traffic noise are the main environmental noise sources considered according to END's prerequisites. Also following the particular characteristics of the country (e.g. leisure facilities) we considered recreational areas and construction sites for our analysis, as well as the cumulative effects of noise sources. The spatial analysis of QAs in open country indicated that the higher values of clustering are found in places of high biodiversity value (as these were characterized by the Habitat's Directive 92/43/EEC), thus multiplying the need for QAs to be preserved.Although distance-based criteria are considerably less accurate than true noise levels calculations, our research serves as a first step for the estimation of QAs in open country at the national level, before moving on to on-site measurements for the complete definition of QAs (at the regional level), thus providing a rapid, comprehensible but above all a cost-effective solution for the assessment of QAs by management responsibles.     

Burnout among pilots: psychosocial factors related to happiness and performance at simulator training

Abstract

In this study among airline pilots, we aim to uncover the work characteristics (job demands and resources) and the outcomes (job crafting, happiness and simulator training performance) that are related to burnout for this occupational group. Using a large sample of airline pilots, we showed that 40% of the participating pilots experience high burnout. In line with Job Demands-Resources theory, job demands were detrimental for simulator training performance because they made pilots more exhausted and less able to craft their job, whereas job resources had a favourable effect because they reduced feelings of disengagement and increased job crafting. Moreover, burnout was negatively related to pilots’ happiness with life. These findings highlight the importance of psychosocial factors and health for valuable outcomes for both pilots and airlines.

Practitioner Summary: Using an online survey among the members of a European pilots’ professional association, we examined the relationship between psychosocial factors (work characteristics, burnout) and outcomes (simulator training performance, happiness). Forty per cent of the participating pilots experience high burnout. Job demands were detrimental, whereas job resources were favourable for simulator training performance/happiness.

Twitter text: 40% of airline pilots experience burnout and psychosocial work factors and burnout relate to performance at pilots’ simulator training.     

Effect of replacing soybean meal by extruded chickpeas in the diets of growing-finishing pigs on meat quality

The main objective of this study was to evaluate the effect of the replacement of soybean meal by extruded chickpeas in diets of growing-finishing pigs on meat quality. In a 17wk study 48 growing-finishing crossbred pigs were fed ad libitum. The experimental design included four treatments, each one of 12 pigs; the ECKP0 treatment was fed with diet containing soybean meal and no chickpeas (control), while treatments ECKP100, ECKP200 and ECKP300 were fed with diets containing 100, 200 and 300kg/t of extruded chickpeas, respectively. The lean meat quality of the longissimus lumborum et thoracis muscle was evaluated by chemical analysis (moisture, protein, fat and ash), fatty acid profile, pH measurement, cooking loss, color evaluation, and sensory evaluation. Odor and taste, tenderness, juiciness, and overall acceptability were scored on 1-10 scales by a group of 10 experienced assessors after a standard cooking regime. Small differences were observed between control and experimental groups in chemical composition (P>0.05). Fatty acid profiles, pH measurements and color evaluation did not differ among treatments (P>0.05), while cooking loss was significantly lower in the control group (P<0.05). The taste panel gave slightly higher scores for the tenderness and juiciness for the control group compared with the chickpea treatments (P<0.05). No differences were observed between control and experimental groups in taste scores (P>0.05). It is concluded that the replacement of soybean meal by extruded chickpeas, when substituted isonitrogenously and isoenergetically at inclusion levels up to 300kg/t of pig, does not influence significantly meat quality.     

Accounting for Soil Aging When Assessing Liquefaction Potential

It has been recognized that liquefaction resistance of sand increases with age due to processes such as cementation at particle contacts and increasing frictional resistance resulting from particle rearrangement and interlocking. As such, the currently available empirical correlations derived from liquefaction of young Holocene sand deposits, and used to determine liquefaction resistance of sand deposits from in situ soil indices [standard penetration test (SPT), cone penetration test (CPT), shear wave velocity test (Vs)], are not applicable for old sand deposits. To overcome this limitation, a methodology was developed to account for the effect of aging on the liquefaction resistance of old sand deposits. The methodology is based upon the currently existing empirical boundary curves for Holocene age soils and utilizes correction factors presented in the literature that comprise the effect of aging on the in situ soil indices as well as on the field cyclic strength (CRR). This paper describes how to combine currently recorded SPT, CPT, and Vs values with corresponding CRR values derived for aged soil deposits to generate new empirical boundary curves for aged soils. The method is illustrated using existing geotechnical data from four sites in the South Carolina Coastal Plain (SCCP) where sand boils associated with prehistoric earthquakes have been found. These sites involve sand deposits that are 200,000?to?450,000?years in age. This work shows that accounting for aging of soils in the SCCP yields less conservative results regarding the current liquefaction potential than when age is not considered. The modified boundary curves indicate that old sand deposits are more resistant to liquefaction than indicated by the existing empirical curves and can be used to evaluate the liquefaction potential at a specific site directly from the current in situ properties of the soil.     

GnRH Analogues as a Co-Treatment to Therapy in Women of Reproductive Age with Cancer and Fertility Preservation

In this review, we analyzed existing literature regarding the use of Gonadotropin-releasing Hormone (GnRH) analogues (agonists, antagonists) as a co-treatment to chemotherapy and radiotherapy. There is a growing interest in their application as a prophylaxis to gonadotoxicity caused by chemotherapy and/or radiotherapy due to their ovarian suppressive effects, making them a potential option to treat infertility caused by such chemotherapy and/or radiotherapy. They could be used in conjunction with other fertility preservation options to synergistically maximize their effects. GnRH analogues may be a valuable prophylactic agent against chemotherapeutic infertility by inhibiting rapid cellular turnover on growing follicles that contain types of cells unintentionally targeted during anti-cancer treatments. These could create a prepubertal-like effect in adult women, limiting the gonadotoxicity to the lower levels that young girls have. The use of GnRH agonists was found to be effective in hematological and breast cancer treatment whereas for ovarian endometrial and cervical cancers the evidence is still limited. Studies on GnRH antagonists, as well as the combination of both agonists and antagonists, were limited. GnRH antagonists have a similar protective effect to that of agonists as they preserve or at least alleviate the follicle degradation during chemo-radiation treatment. Their use may be preferred in cases where treatment is imminent (as their effects are almost immediate) and whenever the GnRH agonist-induced flare-up effect may be contra-indicated. The combination treatment of agonists and antagonists has primarily been studied in animal models so far, especially rats. Factors that may play a role in determining their efficacy as a chemoprotective agent that limits gonadal damage, include the type and stage of cancer, the use of alkylating agents, age of patient and prior ovarian reserve. The data for the use of GnRH antagonist alone or in combination with GnRH agonist is still very limited. Moreover, studies evaluating the impact of this treatment on the ovarian reserve as measured by Anti-Müllerian Hormone (AMH) levels are still sparse. Further studies with strict criteria regarding ovarian reserve and fertility outcomes are needed to confirm or reject their role as a gonadal protecting agent during chemo-radiation treatments.     

Angiogenesis and Anti-Angiogenic Treatment in Prostate Cancer: Mechanisms of Action and Molecular Targets

Prostate cancer (PC) is the most common cancer in men and the second leading cause of cancer-related death worldwide. Many therapeutic advances over the last two decades have led to an improvement in the survival of patients with metastatic PC, yet the majority of these patients still succumb to their disease. Antiagiogenic therapies have shown substantial benefits for many types of cancer but only a marginal benefit for PC. Ongoing clinical trials investigate antiangiogenic monotherapies or combination therapies. Despite the important role of angiogenesis in PC, clinical trials in refractory castration-resistant PC (CRPC) have demonstrated increased toxicity with no clinical benefit. A better understanding of the mechanism of angiogenesis may help to understand the failure of trials, possibly leading to the development of new targeted anti-angiogenic therapies in PC. These could include the identification of specific subsets of patients who might benefit from these therapeutic strategies. This paper provides a comprehensive review of the pathways involved in the angiogenesis, the chemotherapeutic agents with antiangiogenic activity, the available studies on anti-angiogenic agents and the potential mechanisms of resistance.     

Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential

The serine/threonine kinase mechanistic target of rapamycin (mTOR) plays a pivotal role in the regulation of cell proliferation, survival, and motility in response to availability of energy and nutrients as well as mitogens. The mTOR signaling axis regulates important biological processes, including cellular growth, metabolism, and survival in many tissues. In the skin, dysregulation of PI3K/AKT/mTOR pathway may lead to severe pathological conditions characterized by uncontrolled proliferation and inflammation, including skin hyperproliferative as well as malignant diseases. Herein, we provide an update on the current knowledge regarding the pathogenic implication of the mTOR pathway in skin diseases with inflammatory features (such as psoriasis, atopic dermatitis, pemphigus, and acne) and malignant characteristics (such as cutaneous T cell lymphoma and melanoma) while we critically discuss current and future perspectives for therapeutic targeting of mTOR axis in clinical practice.     

The Role of Exosomal Non-Coding RNAs in Colorectal Cancer Drug Resistance

Background: Colorectal cancer (CRC) is one of the most common types of cancer diagnosed worldwide with high morbidity; drug resistance is often responsible for treatment failure in CRC. Non-coding RNAs (ncRNAs) play distinct regulatory roles in tumorigenesis, cancer progression and chemoresistance. Methods: A literature search was conducted in PubMed database in order to sum up and discuss the role of exosomal ncRNAs (ex-ncRNAs) in CRC drug resistance/response and their possible mechanisms. Results: Thirty-six (36) original research articles were identified; these included exosome or extracellular vesicle (EV)-containing microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and small-interfering (siRNAs). No studies were found for piwi-interacting RNAs. Conclusions: Exosomal transfer of ncRNAs has been documented as a new mechanism of CRC drug resistance. Despite being in its infancy, it has emerged as a promising field for research in order to (i) discover novel biomarkers for therapy monitoring and/or (ii) reverse drug desensitization.