Changes in serum thyrotropin (TSH) in man during halofenate administration

Halofenate, a serum lipid-lowering agent which inhibits binding of thyroid hormone to thyroxine-binding globulin (TBG), was administered daily for 14 days to 8 hypothyroid subjects with elevated TSH concentrations as a result of incomplete thyroxine (T4) therapy. Drug administration resulted in mean increases in serum dialyzable fraction T4 (DFT4) of 52% over pretreatment levels (P less than 0.01) and in dialyzable fraction triiodothyronine (DFT3) of 26% in 7 subjects, (P less than 0.01). During halofenate treatment in these 7 subjects, serum TSH concentrations decreased significantly (mean = 39%, P less than 0.01) when DFT4 and DFT3 were increased by halofenate. In only two subjects was there a convincing temporal relationship between increased serum absolute free T4 (AFT4) and decreased serum TSH concentrations. Contrary to what would be predicted from the "free hormone hypothesis", changes in serum TSH concentration in these hypothyroid patients appeared to relate primarily to changes in the free fraction of circulating T4 and T3 (DFT4, DFT3), rather than to alterations in AFT4 or AFT3. Halofenate did not alter serum TBG binding capacity. An eighth subject did not show increased DFT4 and DFT3 during halofenate treatment despite achievement of therapeutic serum levels of the agent; in this patient, serum TSH levels rose progressively throughout the period of inadequate T4 replacement and halofenate administration. In hypothyroid patients, short-term halofenate use suggests that the pituitary-thyroid hormone feedback circuit can respond to increases in serum DFT4 and DFT3 in the absence of detactable increases in absolute free hormone concentrations.     

A Suite of Tools for Debugging Distributed Autonomous Systems

This paper describes a set of tools that enables developers to log and analyze the run-time behavior of distributed control systems. A feature of the tools is that they can be applied to distributed systems. The logging tools enable developers to instrument C or C++ programs so that data indicating state changes can be logged automatically in a variety of formats. In particular, run-time data from distributed systems can be synchronized into a single relational database. Tools are also provided for visualizing the logged data. Analysis to verify correct program behavior is done using a new interval logic that is described in this paper. The logic enables system engineers to express temporal specifications for the autonomous control program that are then checked against the logged data. The data logging, visualization, and interval logic analysis tools are all fully implemented. Results are given from a NASA distributed autonomous control system application.     

Mobilization of peripheral blood stem cells in children using G-CSF after carboplatin containing myelosuppressive chemotherapy

PURPOSE: Peripheral blood stem cell (PBSC) apheresis provides an alternative to autologous marrow harvest as a source of hematologic stem cells for transplantation in children with solid tumors. PATIENTS AND METHODS: Eight children with metastatic or recurrent solid tumors underwent 27 apheresis procedures. Recovery from myelosuppressive chemotherapy occurred without continuous daily growth factor support prior to mobilization. Granulocyte colony stimulating factor (G-CSF) at 16 microgs/kg/day was used to increase stem cells in the peripheral circulation. CD 34 positive cells, mononuclear cells (MNC), and CFU-GM were measured in the apheresis products. Prior chemotherapy was examined as a clinical factor that affected PBSC yield. RESULTS: A significant correlation was found between CD 34+/kg and CFU-GM/kg of the products (r = 0.758, P < 0.001). Patients receiving cumulative doses of carboplatin over 1,600 mg/m2 produced adequate MNC (1 x 10(8)/kg) but yielded significantly less CD 34+ cells or CFU-GM than those patients receiving less carboplatin. Prior doses of etoposide and ifosfamide did not effect PBSC yield. CONCLUSIONS: The mobilization technique was well tolerated, and the products obtained produced trilineage engraftment in the patients that underwent peripheral blood stem cell transplantation. Peripheral blood stem cell apheresis in children can be optimized by selection of appropriate candidates and mobilization with G-CSF after an absence of hematopoietic growth factor support.     

Logical approximation for program analysis

The abstract interpretation of programs relates the exact semantics of a programming language to a finite approximation of those semantics. In this article, we describe an approach to abstract interpretation that is based in logic and logic programming. Our approach consists of faithfully representing a transition system within logic and then manipulating this initial specification to create a logical approximation of the original specification. The objective is to derive a logical approximation that can be interpreted as a terminating forward-chaining logic program; this ensures that the approximation is finite and that, furthermore, an appropriate logic programming interpreter can implement the derived approximation. We are particularly interested in the specification of the operational semantics of programming languages in ordered logic, a technique we call substructural operational semantics (SSOS). We show that manifestly sound control flow and alias analyses can be derived as logical approximations of the substructural operational semantics of relevant languages.     

BetweenIT: An Interactive Tool for Tight Inbetweening

The generation of inbetween frames that interpolate a given set of key frames is a major component in the production of a 2D feature animation. Our objective is to considerably reduce the cost of the inbetweening phase by offering an intuitive and effective interactive environment that automates inbetweening when possible while allowing the artist to guide, complement, or override the results. Tight inbetweens, which interpolate similar key frames, are particularly time‐consuming and tedious to draw. Therefore, we focus on automating these high‐precision and expensive portions of the process. We have designed a set of user‐guided semi‐automatic techniques that fit well with current practice and minimize the number of required artist‐gestures. We present a novel technique for stroke interpolation from only two keys which combines a stroke motion constructed from logarithmic spiral vertex trajectories with a stroke deformation based on curvature averaging and twisting warps. We discuss our system in the context of a feature animation production environment and evaluate our approach with real production data.     

Pesticide residues in foodstuffs in Great Britain: XII.—Organochlorine insecticide residues in hens' eggs from battery,deep-Utter and free-range systems and from houses containing insecticide thermal vaporisers

A study has been made of the organochlorine pesticide residues in hens' eggs produced in battery, deep-litter and free-range systems. Low residues (less than 0.05 ppm) were found except where the birds or their houses had been deliberately treated with pesticides to eradicate fleas or lice. A separate study was also made of eggs produced in houses which had insecticide thermal vaporisers installed in them. The results were variable, depending on a number of factors, but relatively high levels of BHC and DDT were found regularly in the eggs from some of these houses.     

Carbon Diffusion in Lanthanum Erbium Carbide Stabilized in the Cubic Fluorite Structure

Lanthanum erbium carbide, La_0.5Er_0.5C₂, a salt-like carbide with a cubic fluorite phase structure, has been produced from ¹³C, allowing carbon diffusion rate to be determined using ¹²C. Carbon in salt-like carbides exhibits significant ionicity, and a high carbon diffusion rate would enable a new class of high temperature fuel cells based on carbon-ion transport. The complete lack of carbon diffusion data for salt-like carbides is the motivation for this work. The carbon diffusion rate in La_0.5Er_0.5C₂ has now been determined to be 2.0 ± 0.8 × 10⁻¹³ cm²/s at 850 °C, increasing to 1.8 ± 0.8 × 10⁻¹¹ cm²/s at 1150 °C, with an activation energy of about 95 kJ/mole. These diffusion rates are too low for a carbon-ion fuel cell, but a number of other salt-like carbides exist. Be₂C, in particular, is a salt-like carbide with an antifluorite structure, and should have higher carbon-ion diffusion than cubic La_0.5Er_0.5C₂ due to the unoccupied octahedral sites in the antifluorite structure, but Be₂C presents special difficulties due to the toxic nature of its hydrolysis products.     

Use of Steel Slag Leach Beds for the Treatment of Acid Mine Drainage

Steel slag from the Waylite steel-making plant in Bethlehem, Pennsylvania was leached with acidic mine drainage (AMD) of a known quality using an established laboratory procedure. Leaching continued for 60 cycles and leachates were collected after each cycle. Results indicated that the slag was very effective at neutralizing acidity. The AMD/slag leachates contained higher average concentrations of Ba, V, Mn, Cr, As, Ag, and Se and lower average concentrations of Sb, Fe, Zn, Be, Cd, Tl, Ni, Al, Cu, and Pb than the untreated AMD. Based on these tests, slag leach beds were constructed at the abandoned McCarty mine site in Preston County, West Virginia. The leach beds were constructed as slag check dams below limestone-lined settling basins. Acid water was captured in limestone channels and directed into basins to leach through the slag dams and discharge into a tributary of Beaver Creek. Since installation in October 2000, the system has been consistently producing net alkaline, pH 9 water. The treated water is still net alkaline and has a neutral pH after it encounters several other acidic seeps downstream.     

Microbial partitioning to settleable particles in stormwater

The degree to which microbes in the water column associate with settleable particles has important implications for microbial transport in receiving waters, as well as for microbial removal via sedimentation (i.e. detention basins). The partitioning behavior of several bacterial, protozoan and viral indicator organisms is explored in three urban streams under both storm and dry weather conditions. The fraction of organisms associated with settleable particles in stormwater is estimated through use of a centrifugation technique which is calibrated using suspensions of standard particles (e.g., glass, latex). The fraction of organisms associated with settleable particles varies by type of microbe, and the partitioning behavior of each organism generally changes between dry weather and storm conditions. Bacterial indicator organisms (fecal coliforms, Escherichia coli, enterococci) exhibited relatively consistent behavior, with an average of 20-35% of organisms associated with these particles in background samples and 30-55% in storm samples. Clostridium perfringens spores exhibited the highest average level of particle association, with storm values varying from 50% to 70%. Results related to total coliphage partitioning were more variable, with 20-60% associated with particles during storms. These estimates should be valuable in surface water quality modeling efforts, many of which currently assume that all microbes exist as free (unattached) organisms.