Muscle fiber composition and blood ammonia levels after intense exercise in humans

The relationship between fiber type composition and the increase in blood ammonia was examined following a maximal O2 consumption (VO2max) test. Muscle biopsies were taken from the middle portion of the vastus lateralis for determination of fiber type percentages. Two subject groups were selected on the basis of a high (HST) or low (LST) percentage of slow-twitch fibers and compared for blood ammonia and lactate levels after exercise at work loads of approximately 85 and 110% of VO2max. An inverse relationship was found between the percentage of slow-twitch fibers and the increase in blood ammonia. Blood ammonia increased after exercise at both 85 and 110% of VO2max. However, the increase was twofold greater for the LST group following the 110% work effort. The increases in blood ammonia and lactate were positively correlated for both groups following exercise. The results suggest that the proportion of slow-twitch fibers plays an important role in determining the magnitude of the increase in blood ammonia after intense exercise.     

Correction of increased prostacyclin synthesis in Bartter's syndrome by indomethacin treatment

The role of prostacyclin and thromboxane A2 in the pathogenesis of Bartter's syndrome was investigated by measurement of the urinary excretion of 6-keto-PGF1 alpha and thromboxane B2, respectively, in five patients. The prostaglandin metabolites were extracted from urine by a reproducible method and measured by specific radioimmunoassays. The patients with Bartter's syndrome excreted about four-times as much 6-keto-PGF1 alpha as the normal controls. In contrast, there was no significant difference in the urinary excretion of thromboxane B2 between the patients and the controls. In a second part of the study, three patients were treated with indomethacin (150 mg/day for four days), an inhibitor of prostaglandin synthesis. This regimen suppressed urinary excretion of 6-keto-PGF1 alpha by 43% and that of thromboxane B2 by 46%. It is suggested that the increase in prostacyclin production is responsible for both the hyperreninemia and and the other endocrine derangements as well as the hyporesponsiveness of blood pressure to intravenous infusion of vasopressors in patients with Bartter's syndrome.     

Behavioral consequences of crowding in the deermouse (Peromyscus maniculatus).

Hypothesized that, when the degree of crowding is manipulated by varying group size in cages of equal size, it is probable that crowded animals will engage in more contact than uncrowded animals. Home-cage observation of 24 male and 24 female deer mice indicates that crowded Ss do, in fact, engage in more contact behavior. Both home-cage observation and testing in pairs for pain-elicited aggression reveal that (a) crowded Ss display more agonistic behavior than uncrowded Ss, and (b) agonistic behavior increases with prolonged crowding. Support is obtained for the theory that the effect of crowding derives from contact with conspecifics. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-Monitoring, Activity Levels, and Mood in the Development and Maintenance of Depression.

The reactive effect on mood of self-monitoring pleasant and unpleasant events was assessed. Forty-five females spent 28 days monitoring in one of four conditions: (a) pleasant events, (b) unpleasant events, (c) both, and (d) no monitoring. Motor activity level (pedometer recordings) and mood were also assessed daily. Class of event monitored was not found to influence mood. Correlations between mood and both pleasant and unpleasant events were found even with activity level partialed out. Implications for self-monitoring assessment in depression therapy programs and for models of depression are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)