Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of substituted 3-chloro-5,8-dimethoxy-1,4-naphthoquinone and related compounds

2-Amino (6), 2-alkylamino (7-8), 2-methoxy (9), 2-acetamido (10), and 5,8-diacetoxy (11) derivatives of the lead compound 2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone (4) were synthesized, together with 6,7-dichloro-5,8dimethoxy-1,4-naphthoquinone (5), a positional isomer of 4. Antiplatelet, antiinflammatory, and antiallergic activities were evaluated, and most compounds were quite potent in all assays. Compounds 5 and 9-11 were especially active; however, 5 was ineffective against neutrophil superoxide formation, and 10 was ineffective against mast cell degranulation.     

Memorizing and recalling spatial-temporal patterns in an oscillator model of the hippocampus

We describe the model of the hippocampus consisting of interactive oscillators with input from the entorhinal cortex (modulating the main information flow by a theta rhythm) and the septum (a theta rhythm generator). When interconnections between oscillators are allowed to strengthen in an adaptive way, the network can be trained using a series of lessons. This results in a connection matrix that memorizes the temporal sequence of inputs. Presenting one of the lessons to the trained network results in reproduction of the remainder of the sequence. In this paper, we create such a connection matrix, derive from it an appropriate Markov chain and simulate the chain to illustrate its dynamics.     

Fatigue strength of welded joints in austenitic Cr-Ni steels

Abstract

High quality corrosion resistant Cr-Ni steels are used in many branches of industry. Constructors are faced with the problem of correctly dimensioning statically and dynamically loaded parts, but have little data available for dynamically loaded welded constructions of high alloy austenitic steels. To close this gap fatigue strength tests were carried out on three different steels and five different welded joints.     

Use of an immunoassay as a means to detect polychlorinated biphenyls in animal fat

In this paper we describe the validation and utilization of the Hybrizyme TM DELFIA immunoassay for detecting polychlorinated biphenyls (PCBs) in animal fat. The immunoassay incorporates a rapid sample processing protocol that has been optimized to detect concentrations of PCBs in animal fat at or above 200ng/g. The limit of detection of the assay was less than 50ng/g. When the action level for the DELFIA assay was set at 100ng/g to detect samples having 200ng/g or more PCBs, the false negative rate was estimated at 0.2% . The false positive rate depends on the concentration of PCBs in the sample population and was estimated at 4% and 7% for samples having 10ng/ g and 20ng/g PCBs, respectively. By utilizing the DELFIA assay system to select for positive samples and GC/MS analysis for confirmation analysis, an accurate and cost-effective programme has been established for the high throughput detection of PCBs in animal products.     

Introduction to the Asian Energy Security project: Project organization and methodologies

The spectacular recent economic growth in the Asia-Pacific region in general, and in many of the economies of Northeast Asia in particular, has spurred a vast expansion in the need for energy services, and an expansion in the demand for the fuels that help to supply these services. Future projections suggest that the growth of fossil fuel use in Northeast Asia, especially in China, will have major consequences for financial and fuel markets and pollution both regionally and globally. Before the project described in this paper was initiated, there was no ongoing forum for energy experts from all of the countries of the region to meet, informally and in an unofficial capacity, to discuss openly and in a targeted fashion the energy situations in their countries, and to work together to evaluate the energy efficiency costs and benefits of different ways of meeting regional demand. The Asian Energy Security (AES) project provides such a forum, and as such constitutes a unique resource in the engagement of the countries of Northeast Asia on the topic of energy security.     

Performance analysis of the power conversion unit of a solar chimney power plant

The power conversion unit (PCU) of a large solar chimney power plant consists of one or several turbogenerators, power electronics, a grid interface and the flow passage from collector exit to chimney inlet. The main goals of this paper are to analyze the performance of the PCU and its interaction with the plant as well as to compare three configurations from an efficiency and energy yield point of view.First, a reference plant is defined and the plant performance data taken from simulations with a model found in the literature are analyzed, and the matching of the turbine(s) to the characteristic of the plant is discussed. It was found that a well designed turbine can be run at high efficiency over the entire operating range, as the plant performance data can be fitted using the ellipse law of Stodola.Loss models for all components of the power conversion unit are then defined, and the impact of the various losses on the overall performance is assessed. Three configurations of the PCU are compared, i.e. the single vertical axis, the multiple vertical axis and the multiple horizontal axis turbine configuration. It is found that the single vertical axis turbine has a slight advantage with regards to efficiency and energy yield because certain loss mechanisms are not present. But its output torque is tremendous, making its feasibility questionable. It is shown that with designing the flow passage in an appropriate manner the aerodynamic losses can be kept low. The assumption made by many other researchers that the total-to-total efficiency of the PCU is 80 % has been confirmed with the present model. Further, it has been shown that the PCU efficiency deteriorates significantly with increasing diffuser area ratio but improves only slightly with reducing the diffuser area ratio below unity.     

Die Aktivität von Lipoxigenasen in Getreide sowie Möglichkeiten der Enzymhemmung

Activity of Lipoxygenase in Cereals and Possibilities of Enzyme Inhibition In different feed components the activity of the enzyme lipoxigenase was determined. In cereals the enzyme activity predominantly decreases in the following order: barley, wheat, corn, oats and rye. During the malt process the activity of barley lipoxigenases increases to a very high level. During storage ungerminated grains are showing increasing (barley) or decreasing (wheat) variations in enzyme activity. The addition of propionic acid decreases the activity of lipoxigenases in cereals. The peroxide value of added fat in mixed feed was not influenced by lipoxigenases. For wheat products positive relations between the content of crude protein as well as crude fat and the enzyme activity were ascertained. Heat treaments with temperatures exceeding 100% C lowered the lipoxigenase activity to values below 10% of the untreated sample. The usual temperatures during feed processing, e.g. after conditioning and pelleting, are sufficient to inhibit the enzyme activity almost completely.