Analysis of human fibroadenomas using three-dimensional impedance maps

Three-dimensional impedance maps (3DZMs) are virtual volumes of acoustic impedance values constructed from histology to represent tissue microstructure acoustically. From the 3DZM, the ultrasonic backscattered power spectrum can be predicted and model based scatterer properties, such as effective scatterer diameter (ESD), can be estimated. Additionally, the 3DZM can be exploited to visualize and identify possible scattering sites, which may aid in the development of more effective scattering models to better represent the ultrasonic interaction with underlying tissue microstructure. In this study, 3DZMs were created from a set of human fibroadenoma samples. ESD estimates were made assuming a fluid-filled sphere form factor model from 3DZMs of volume 300×300×300 μm. For a collection of 33 independent human fibroadenoma tissue samples, the ESD was estimated to be 111±40.7 μm. The 3DZMs were then investigated visually to identify possible scattering sources which conformed to the estimated model scatterer dimensions. This estimation technique allowed a better understanding of the spatial distribution and variability of the estimates throughout the volume.     

Nanoparticle Coating for Advanced Optical,Mechanical and Rheological Properties

Primary titania nanoparticles were coated with ultrathin alumina films using Atomic Layer Deposition (ALD). The deposited films were highly uniform and conformal with an average growth rate of 0.2 nm per coating cycle. The alumina films eliminated the surface photocatalytic activity of titania nanoparticles, while maintained their original extinction efficiency of ultraviolet light. Deposited films provided a physical barrier that effectively prevented the titania surface from oxidizing organic material whereas conserving its bulk optical properties. Parts fabricated from coated powders by pressureless sintering had a 13 % increase in surface hardness over parts similarly fabricated from uncoated particles. Owing to its homogeneous distribution, the secondary alumina phase suppressed excessive grain growth. Alumina films completely reacted during sintering to form aluminum titanate composites, as verified by XRD. Coated particles showed a pseudoplastic behavior at low shear rates due to modified colloidal forces. This behavior became similar to the Newtonian flow of uncoated nanoparticle slurries as the shear rate increased. Suspensions of coated particles also showed a decreased viscosity relative to the viscosity of uncoated particle suspensions.     

Comments on “The electromagnetic field of a vertical electricdipole over the Earth or sea” [and reply]

Yokoyama makes some comments on the “numerical distance” contained in the surface wave term in the paper by King and Sandler (see ibid., vol.42, p.383, 1994) comparing it with the one obtained by former authors. He comments on the parameter P in the Fresnel-integral term in the paper. Yokoyama concludes that for the calculation of such a problem in a semi-sphere, the spherical polar coordinate system is preferable to the cylindrical coordinate system including the case of lateral waves. King and Sandler reply to the Comment     

Energy‐Dissipative Matrices Enable Synergistic Toughening in Fiber Reinforced Soft Composites

Tough hydrogels have shown strong potential as structural biomaterials. These hydrogels alone, however, possess limited mechanical properties (such as low modulus) when compared to some load‐bearing tissues, e.g., ligaments and tendons. Developing both strong and tough soft materials is still a challenge. To overcome this obstacle, a new material design strategy has been recently introduced by combining tough hydrogels with woven fiber fabric to create fiber reinforced soft composites (FRSCs). The new FRSCs exhibit extremely high toughness and tensile properties, far superior to those of the neat components, indicating a synergistic effect. Here, focus is on understanding the role of energy dissipation of the soft matrix in the synergistic toughening of FRSCs. By selecting a range of soft matrix materials, from tough hydrogels to weak hydrogels and even a commercially available elastomer, the toughness of the matrix is determined to play a critical role in achieving extremely tough FRSCs. This work provides a good guide toward the universal design of soft composites with extraordinary fracture resistance capacity.     

LROC analysis of detector-response compensation in SPECT

Localization ROC (LROC) observer studies examined whether detector response compensation (DRC) in ordered-subset, expectation-maximization (OSEM) reconstructions helps in the detection and localization of hot tumors. Simulated gallium (Ga-67) images of the thoracic region were used in the study. The projection data modeled the acquisition of attenuated 93- and 185-keV photons with a medium-energy parallel-hole collimator, but scatter was not modeled. Images were reconstructed with five strategies: 1) OSEM with no DRC; 2) OSEM preceded by restoration filtering; 3) OSEM with iterative DRC; 4) OSEM with an ideal DRC; and 5) filtered backprojection (FBP) with no DRC. All strategies included attenuation correction. There were four LROC studies conducted. In a study using a single tumor activity, the ideal DRC offered the best performance, followed by iterative DRC, restoration filtering, OSEM with no DRC, and FBP. Statistical significance at the 5% level was found between all pairs of strategies except for restoration filtering and OSEM with no DRC. A similar ranking was found for a more realistic study using multiple tumor activities. Additional studies considered the effects of OSEM iteration number and tumor activity on the detection improvement that iterative DRC offered with respect to OSEM with no DRC.     

Fields and currents in the organs of the human body when exposed topower lines and VLF transmitters

A study is made of the electric fields and currents induced in the organs of the human body when exposed to high-voltage 50-60-Hz transmission lines and 10-30-kHz high-power transmitters. Relevant analyses previously carried out are summarized and supplemented with detailed investigations that complete the picture. Incomplete, misleading, and incorrect statements and methods in the related literature are pointed out, completed, and corrected. The major contribution is to provide quantitatively accurate, relatively simple analytic formulas that relate the incident electric field to the induced field in the organs of the body. The formulation and solution of the underlying integral equation are carried out in an Appendix     

Weighted Adaptive Lifting-Based Wavelet Transform for Image Coding

In this paper, a new weighted adaptive lifting (WAL)-based wavelet transform is presented. The proposed WAL approach is designed to solve the problems existing in the previous adaptive directional lifting (ADL) approach, such as mismatch between the predict and update steps, interpolation favoring only horizontal or vertical direction, and invariant interpolation filter coefficients for all images. The main contribution of the proposed approach consists of two parts: one is the improved weighted lifting, which maintains the consistency between the predict and update steps as far as possible and preserves the perfect reconstruction at the same time; another is the directional adaptive interpolation, which improves the orientation property of the interpolated image and adapts to statistical property of each image. Experimental results show that the proposed WAL-based wavelet transform for image coding outperforms the conventional lifting-based wavelet transform up to 3.06 dB in PSNR and significant improvement in subjective quality is also observed. Compared with the ADL-based wavelet transform, up to 1.22-dB improvement in PSNR is reported.     

Fully Integrated CMOS Power Amplifier With Efficiency Enhancement at Power Back-Off

This paper presents a new approach for power amplifier design using deep submicron CMOS technologies. A transformer based voltage combiner is proposed to combine power generated from several low-voltage CMOS amplifiers. Unlike other voltage combining transformers, the architecture presented in this paper provides greater flexibility to access and control the individual amplifiers in a voltage combined amplifier. In this work, this voltage combining transformer has been utilized to control output power and improve average efficiency at power back-off. This technique does not degrade instantaneous efficiency at peak power and maintains voltage gain with power back-off. A 1.2 V, 2.4 GHz fully integrated CMOS power amplifier prototype was implemented with thin-oxide transistors in a 0.13 mum RF-CMOS process to demonstrate the concept. Neither off-chip components nor bondwires are used for output matching. The power amplifier transmits 24 dBm power with 25% drain efficiency at 1 dB compression point. When driven into saturation, it transmits 27 dBm peak power with 32% drain efficiency. At power back-off, efficiency is greatly improved in the prototype which employs average efficiency enhancement circuitry.