A preprocessor for geotomographic imaging of irregular geometricscans

An algorithm that acts as a preprocessor to the straight ray algebraic reconstruction technique (ART) algorithm, for the purpose of dealing with nonrectangular scanning geometries, is described. The mathematics of ART in its elementary form is reviewed, showing how the discretization of the rectangular scanning space defines quantities in the projection matrix of the algorithm. A triangular discretization approach for the scanning space that allows nonrectangular or twisted plane geometries to be addressed is proposed, and the effect of this approach on the projection matrix is discussed. An algorithm for determining the projection matrix under these discretization conditions is described, followed by some commentary on its computer implementation. The performance of this preprocessor algorithm, working with standard ART, in reconstructing various synthetic images is demonstrated     

On the Achievable Delay Margin Using LTI Control for Unstable Plants

Handling delays in control systems is difficult and is of long-standing interest. It is well known that, given a finite-dimensional linear time-invariant (FDLTI) plant and controller forming a strictly proper stable feedback connection, closed-loop stability will be maintained under a small delay in the feedback loop, although most closed loop systems become unstable for large delays. One previously unsolved fundamental problem in this context is whether, for a given FDLTI plant, an arbitrarily large delay margin can be achieved using LTI control. Here, we adopt a frequency domain approach and demonstrate that, for a strictly proper real rational plant, there is a uniform upper bound on the delay that can be tolerated when using an LTI controller, if and only if the plant has at least one closed right half plane pole not at the origin. We also give several explicit upper bounds on the achievable delay margin, and, in some special cases, demonstrate that these bounds are tight.     

Results of bypasses to the anterior tibial artery through the interosseous membrane

Two month-old Wistar male albino rats were exposed during a 30-day period to a daily oral intake ad libitum of either 200 microg/mL Cd (as CdCl2), 0.1 microg/mL Se (as Na-selenite), or the same dosages of Cd + Se in drinking water. The daily intake from the water was calculated to be 15 mg Cd/kg and 7 microg Se/kg. Cadmium (Cd) accumulates in the heart (p < 0.005) and, in rats, decreases both body mass growth (p < 0.005) and heart mass (p < 0.02). Selenium (Se) significantly decreases the negative effect of Cd on body mass growth. In the hearts of Cd-treated rats, cadmium caused the decrease (p < 0.05) of selenium-dependent glutathione peroxidase (GSH-Px, EC 1.11.1.9) activity. At the same time, the activities of total superoxide dismutase (total SOD, EC 1.15.1.1), manganese-containing superoxide dismutase (Mn SOD), and copper-zinc-containing superoxide dismutase (CuZn SOD) were increased (p < 0.005). The activities of total SOD, CuZn SOD (p < 0.005), GSH-Px (p < 0.02), and glutathione-S-transferase (GST, p < 0.005) were increased in the hearts of Se-treated rats. However, by concomitant administration of Cd and Se, these changes were diminished (total SOD, GST) or were completely eliminated (Mn SOD, GSH-Px). These results indicate that Se only partly diminishes the effects of Cd cardiotoxicity.     

Undershoot and settling time tradeoffs for nonminimum phase systems

It has been known for some time that real nonminimum phase zeros imply undershoot in the step response of linear systems. Bounds on such undershoot depend on the settling time demanded and the zero locations. In this note, we review such constraints for linear time invariant systems and provide new stronger bounds that consider simultaneously the effect of two real nonminimum phase zeros. Using the concept of zero dynamics, we extend these results to a class of nonlinear systems.     

Establishment of human parotid pleomorphic adenoma cells in culture: morphological and biochemical characterization

This study reports the establishment of alpha-amylase-producing human parotid pleomorphic adenoma cell lines (2HP and 2HP1) which have been maintained in culture for over 1 yr. The procedures required preparation of cellular clumps from tumor tissue and plating them on plasma clot or precoated dishes. During the initial phase of growth they required modified MCDB-153 medium without serum. When cells showed signs of degeneration they were changed to MCDB-153 medium containing first 2% and then 10% heat inactivated fetal bovine serum. Although cells grew well in MCDB-153 containing 10% serum, the epithelial cell morphology was not distinct. Therefore, the growth and morphology of cells grown in MCDB-10% serum were compared with those in RPMI growth medium containing 10% fetal bovine serum and F12 containing 10% agammaglobulin newborn bovine serum. Although the growth of cells was a little slower in F12 medium than those in MCDB and RPMI, the epithelial cell morphology was maintained better than in other growth media. The cells of 2HP and 2HP1 produce low levels of alpha-amylase and relatively high levels of alpha-amylase mRNAs of 1176 and 702 bp and contain neurofilament-160, a neuronal-specific marker. The cells of 2HP1 are tumorigenic when tested in athymic mice, but the cells of 2HP are not. The establishment of amylase-producing human parotid adenoma cell lines of different characteristics in culture provides a new opportunity to study the mechanisms of differentiation and transformation, and regulation of alpha-amylase in these cells.     

Epidemiology of infection with Epstein-Barr virus types 1 and 2: lessons from the study of a T-cell-immunocompromised hemophilic cohort

In apparent contrast to earlier work on Epstein-Barr virus (EBV) carriage in the general Caucasian population, in vitro virus isolations from human immunodeficiency virus (HIV)-positive male homosexual cohorts have shown frequent examples of multiple EBV infection and an overall prevalence of type 2 EBV strains exceeding 30%. Here we ask to what extent these findings might hold true in another T-cell-immunocompromised cohort, HIV-positive hemophilic patients. Resident EBV strains were rescued within lymphoblastoid cell lines derived from the blood and throat washings of 39 such individuals, using the same in vitro protocols of virus isolation as for the homosexual cohort. A mean of 19 independent cell lines was made per patient, and in each case the resident virus was characterized by PCR-based viral genomic analysis and by immunoblotting to reveal the viral "EBNAprint." By these criteria a significant proportion (14 of 39) of the hemophilic cohort carried more than one EBV strain, suggesting that T-cell impairment does indeed sensitize virus carriers to reinfection with new strains of exogenously transmitted virus. However, the overall incidence of type 2 EBV infection was 10%, which is close to that observed in the earlier work with healthy carriers and substantially lower than that seen in HIV-positive homosexuals. We infer that type 2 EBV is relatively rare in the general Caucasian population but has become endemic in the homosexual community.     

Non-random associations between fears, beliefs and behaviors among panic patients

Self-report questionnaires have been used to compare panic patients' fears, anxious thoughts and behaviors with those of a group of controls. Individual items revealed significant differences between groups in all three areas: factor analysis revealed group differences in the pattern of intraquestionnaire associations between items. Correlational analysis of factor scores revealed significant group differences in the pattern of interquestionnaire associations. These findings only partly support a formulation of panic based upon "catastrophic interpretations." On the other hand, they do provide evidence of cognitive rigidity among panic patients which can be interpreted as evidence of impaired effortful processing when anxious.