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91.
Suman Sarkar 《Sequential Analysis》2016,35(2):207-215
We consider two treatment comparison in a clinical trial setup where the responses from one treatment are a priori known for a fixed number of individuals and patients are allocated in a groupsequential way for the other treatment using inverse sampling. We consider the odds ratio as the measure of treatment difference at the end of each group, where for the calculation of odds ratios we consider the full data on one treatment, which are a priori known, and the available data on the other treatment up to that point of time. We have calculated the optimal number of index subjects for inverse sampling and examine the effects of different type I and type II error spending functions on group sequential testing in this context. The methodology is illustrated by using a real data set. 相似文献
92.
Rohit Kumar Avik Sarkar William Ketterhagen Bruno Hancock Jennifer Curtis Carl Wassgren 《American Institute of Chemical Engineers》2018,64(6):1986-2001
How the choice of elastic normal contact force model affects predictions from discrete element method simulations of spherocylindrical particles is investigated in this article. Three force models were investigated: (1) a Hertzian force model (HFM) which assumes a circular contact area; (2) a linear force model (LFM) with a constant stiffness; and (3) a modified HFM (MFM) that accounts for various contact areas and contact transitions. With the MFM, transitions between contact area types must be accounted for otherwise discontinuities in the contact force can occur. It is found that simple force models (HFM, LFM) can be substituted for more accurate force models if only force data and bulk properties are of interest. However, if more detailed contact information, such as contact area, contact overlap, contact duration, or collision frequency, are needed, for example, in population balance models and transient liquid bridge modeling, then a more accurate force model should be used. © 2018 American Institute of Chemical Engineers AIChE J, 64: 1986–2001, 2018 相似文献
93.
Hyun-Jin HongSwapan Kumar Sarkar Byong-Taek Lee 《Journal of the European Ceramic Society》2012,32(3):657-663
In this study, needle-shape TiO2 fibers were successfully fabricated inside a micro-channeled Al2O3-ZrO2 composite porous membrane system using sol-gel method. The micro-channeled Al2O3-ZrO2 composite was fabricated using the fibrous monolithic (FM) process. Pure anatase phase TiO2 was crystallized from the as-coated amorphous phase during calcination at 510 °C. The TiO2 fibers grew on the surface frame of the micro-channeled Al2O3-ZrO2 composite membrane and fully covered the inside of the micro-channeled pores. The specific surface area of the TiO2 coated membrane system was dramatically increased by over 100 fold compared to that of the non-coated system. The photocatalytic activity of the membrane was also assessed and was shown to very effectively convert organic materials. Thus, this novel membrane holds promise for use as an advanced filtration system. 相似文献
94.
Development of Bigels Based on Stearic Acid–Rice Bran Oil Oleogels and Tamarind Gum Hydrogels for Controlled Delivery Applications 下载免费PDF全文
Suprio R. Paul Dilshad Qureshi Yamini Yogalakshmi Suraj K. Nayak Vinay K. Singh Irshaan Syed Preetam Sarkar Kunal Pal 《Journal of surfactants and detergents》2018,21(1):17-29
In the last few decades, different types of gels have been widely studied as potential drug delivery carriers. In this paper, we propose the synthesis of an oleogel, a tamarind gum hydrogel, and bigels for applications as drug delivery matrices. The oleogel was prepared by mixing stearic acid and rice bran oil, whereas the hydrogel was prepared by mixing tamarind gum with a hydroethanolic solution. Hydrogel‐in‐oleogel and oleogel‐in‐hydrogel bigels were prepared by mixing the hydrogel and the oleogel. The suitability of the formulations for controlled drug release applications was thoroughly examined using microscopy, Fourier transform infrared (FTIR) spectroscopy, as well as mechanical, electrical, thermal, drug release, and antimicrobial studies. An alteration in the microarchitecture of the bigels is observed when the oleogel and the hydrogel are mixed in varying proportions. The associative interactions within the formulations increase with the increase in the hydrogel content. The bigels exhibit the presence of stearic acid melting endotherm (associated with the oleogel) and water evaporation endotherm (associated with the hydrogel). This study suggests that the hydrogel has lowest bulk resistance compared to the other formulations. The structural breakdown of the bigels is composition‐dependent, and the bulk electrical resistance is mainly governed by the oleogel phase. An increase in the diffusion of the moxifloxacin HCl from the formulations is observed with the increase of the hydrogel proportion, which in turn increases the rate of release of the drug. The proposed formulations also exhibit good antimicrobial efficacy. The analysis of these properties suggests that specific formulations can be tailored by need‐based applications of the drug release rate. 相似文献
95.
Raw and dewaxed jute felt composites were prepared with resol and lignin modified phenol formaldehyde resin. Four different types of lignin modified resins were used by replacing phenol with lignin. The lignin modified resins were prepared from purified lignin obtained from paper industry waste black liquor. To investigate bonding between jute and resin, IR spectroscopy of jute felts and composites was carried out. The thermal stability of the composites was assessed by DSC and TGA. It was found that the lignin resin jute composite is thermally more stable than resol composite. XRD of jute felt and composite shows that the crystallinity of the jute fiber increases after composite preparation. The lignin resin composites were tested for water absorption and thickness swelling, and it was found that the results are comparable with those of resol jute composite. Composites prepared from lignin phenol formaldehyde resin with 50% phenol replacement has shown 75% tensile strength retention to that of pure resol jute composite. 相似文献
96.
CFD simulations of pulsed disc and doughnut columns are performed to understand the effects of operating and geometric parameters on axial dispersion and pressure drop in single-phase flow. CFD simulations have been carried out using a two-step approach. In the first step, the flow field is obtained by solving the continuity and the momentum equations along with the equations of the standard k–ε model of turbulence. In the second step, the species transport equation is additionally solved to obtain the residence time distribution and hence the Peclet number and axial dispersion coefficient. The computational approach is validated by comparing its predictions with the experimental data reported in the literature and then used for detailed parametric analysis. 相似文献
97.
The Oxidation of Hydrophobic Aromatic Substrates by Using a Variant of the P450 Monooxygenase CYP101B1 下载免费PDF全文
Md. Raihan Sarkar Joel H. Z. Lee Dr. Stephen G. Bell 《Chembiochem : a European journal of chemical biology》2017,18(21):2119-2128
The cytochrome P450 monooxygenase CYP101B1, from a Novosphingobium bacterium is able to bind and oxidise aromatic substrates but at a lower activity and efficiency than norisoprenoids and monoterpenoid esters. Histidine 85 of CYP101B1 aligns with tyrosine 96 of CYP101A1, which, in the latter enzyme forms the only hydrophilic interaction with its substrate, camphor. The histidine residue of CYP101B1 was mutated to phenylalanine with the aim of improving the activity of the enzyme for hydrophobic substrates. The H85F mutant lowered the binding affinity and activity of the enzyme for β-ionone and altered the oxidation selectivity. This variant also showed enhanced affinity and activity towards alkylbenzenes, styrenes and methylnaphthalenes. For example the rate of product formation for acenaphthene oxidation was improved sixfold to 245 nmol per nmol CYP per min. Certain disubstituted naphthalenes and substrates, such as phenylcyclohexane and biphenyls, were oxidised with lower activity by the H85F variant. Variants at H85 (A and G) designed to introduce additional space into the active site so as to accommodate these larger substrates did not improve the oxidation activity. As the H85F mutant of CYP101B1 improved the oxidation of hydrophobic substrates, this residue is likely to be in the substrate binding pocket or the access channel of the enzyme. The side chain of the histidine might interact with the carbonyl groups of the favoured norisoprenoid substrates of CYP101B1. 相似文献
98.
A. Sarkar K. Boopathy J. Eapen K. L. Murty 《Journal of Materials Engineering and Performance》2014,23(10):3649-3656
Zirconium (Zr) alloys are the primary structural materials of most water reactors. Creep is considered to be one of the important degradation mechanisms of Zr alloys during reactor operating and repository conditions. Zr alloys pick up hydrogen (H2) during their service from the coolant water. Hydrogen can be present in solid solution or precipitated hydride form in Zr alloys depending upon the temperature and concentration. This study reviews the effect of hydrogen on creep behavior of Zr alloys used in the water reactors. 相似文献
99.
DP590 steel sheets were joined by friction stir spot welding using polycrystalline cubic boron nitride tool with an objective to produce bond diameters similar to conventional spot welding nuggets. A range of spindle rotation (400–2400 rev min?1) and plunge speeds (0·03–3·8 mm s?1) were exercised to attain defect free welds in 1·6 mm thick sheets. A bond diameter of 4t1/2, alike minimum nugget diameter criteria for resistance spot welds, resulted in superior mechanical properties than conventional spot welds. The heat inputs corresponding to different welding parameters influenced the weld microstructure, including grain size, phases and their morphology. The bond diameter was higher for higher heat inputs. However, low heat input welds with weld time cycles ~4 s produced more refined microstructure and exhibited similar strengths even with reduced bond size. Plug type failure was associated with larger bond diameters (~7·1 mm), while interfacial failure was observed with smaller welds (~5·4 mm). 相似文献
100.
Ashvi Sanjay Jain Pranita Subhash Pawar Aira Sarkar Vijayabhaskarreddy Junnuthula Sathish Dyawanapelly 《International journal of molecular sciences》2021,22(21)
Among the various types of nanoparticles and their strategy for synthesis, the green synthesis of silver nanoparticles has gained much attention in the biomedical, cellular imaging, cosmetics, drug delivery, food, and agrochemical industries due to their unique physicochemical and biological properties. The green synthesis strategies incorporate the use of plant extracts, living organisms, or biomolecules as bioreducing and biocapping agents, also known as bionanofactories for the synthesis of nanoparticles. The use of green chemistry is ecofriendly, biocompatible, nontoxic, and cost-effective. We shed light on the recent advances in green synthesis and physicochemical properties of green silver nanoparticles by considering the outcomes from recent studies applying SEM, TEM, AFM, UV/Vis spectrophotometry, FTIR, and XRD techniques. Furthermore, we cover the antibacterial, antifungal, and antiparasitic activities of silver nanoparticles. 相似文献