Functional and metabolic evaluation of the hypertrophied heart using MRI and31P-MRS

4. Conclusions Diastolic LV function and myocardial HEP metabolism are impaired only when LVH is caused by permanent pressure or volume overload, and not by a temporary increase in cardiac workload during part of the day as in elite athletes. Therefore, training-induced and pressure/volume-overload-induced LVH seem to represent different phenotypes of LVH, possibly related to genetic reprogramming which only occurs during permanent cardiac overload [17]. Moreover, there is an association between impaired LV diastolic function and altered myocardial HEP metabolism in patients with hypertension and in patients with aortic valve disease. Finally we did not find a correlation between myocardial HEP metabolism and LV mass in any of the groups studied. The latter indicates that LVH should be regarded as an epiphenomenon to cardiac overload, and not as a primary factor causing abnormal HEP metabolism.     

APROMORE: An advanced process model repository

Business process models are becoming available in large numbers due to their widespread use in many industrial applications such as enterprise and quality engineering projects. On the one hand, this raises a challenge as to their proper management: how can it be ensured that the proper process model is always available to the interested stakeholder? On the other hand, the richness of a large set of process models also offers opportunities, for example with respect to the re-use of existing model parts for new models. This paper describes the functionality and architecture of an advanced process model repository, named APROMORE. This tool brings together a rich set of features for the analysis, management and usage of large sets of process models, drawing from state-of-the art research in the field of process modeling. A prototype of the platform is presented in this paper, demonstrating its feasibility, as well as an outlook on the further development of APROMORE.     

Reduction rules for YAWL workflows with cancellation regions and OR-joins

As the need for concepts such as cancellation and OR-joins occurs naturally in business scenarios, comprehensive support in a workflow language is desirable. However, there is a clear trade-off between the expressive power of a language (i.e., introducing complex constructs such as cancellation and OR-joins) and ease of verification. When a workflow contains a large number of tasks and involves complex control flow dependencies, verification can take too much time or it may even be impossible. There are a number of different approaches to deal with this complexity. Reducing the size of the workflow, while preserving its essential properties with respect to a particular analysis problem, is one such approach. In this paper, we present a set of reduction rules for workflows with cancellation regions and OR-joins and demonstrate how they can be used to improve the efficiency of verification. Our results are presented in the context of the YAWL workflow language.     

Evaluation of the effect of a paver’s trolley on productivity, task demands, workload and local discomfort

The objective of this study was to determine the differences in the number of paving stones laid (productivity), task demands, energetic workload, body region discomfort and preference when laying paving stones with or without use of a paver’s trolley (n = 8) in a within-subject controlled study of pavers. The number of paving stones laid and the task demands were measured by means of systematic observations at the workplace. The energetic workload was determined using the percentage of heart rate reserve (%HRR). Body region discomfort was measured using visual analog scales, and the workers’ preference was ascertained via interview. The use of a paver’s trolley had no effect on productivity, %HRR or body region discomfort compared to working without a paver’s trolley. The duration of knee-straining activities did not differ between working with (141 min) and without (146 min) the paver’s trolley. However, six of the eight pavers indicated that, given suitable circumstances, they wanted to use the paver’s trolley.

Relevance to industry

To reduce the chance of work-related low back and knee complaints among pavers, the duration, frequency and intensity of lower back and knee-straining activities should be limited by means of technical measures such as mechanical paving. The paver’s trolley does not appear to reduce knee-straining activities and therefore does not appear useful in reducing the risk of knee complaints and disorders.     

Computing three-dimensional two-phase flows with a mass-conserving level set method

A method is described to compute three- dimensional two-phase flow, allowing large density ratios and coalescence and break-up of bubbles. The level set method is used to describe interfaces, and the volume-of-fluid method is used to ensure mass conservation. Efficiency in computing the interface dynamics is achieved by using a functional relation between the level set and volume-of-fluid functions. Difficulties and remedies in re-initialization of the level set function and inaccurate compution of surface tension are discussed. Test cases for validation are described, and demanding two-bubble computations to show the generality and the versatility of the method are presented.     

State Observation and Diagnosis of Discrete-Event Systems Described by Stochastic Automata

The problems ofstate observation and diagnosis are solved for discrete–eventsystems, which are described by stochastic automata. As manysystems are not observable in the sense that it is possible toreconstruct the state unambiguously, the observation problemis set up as the problem of determining the smallest possibleset of states that are compatible with the measured input andoutput sequences. The diagnostic problem is shown to be, in principle,an observation problem. Conditions for the observability anddiagnosability of stochastic automata are presented. The resultsare illustrated by examples.     

MVA-vaccine in primovaccination against smallpox after the age of three (author's transl)

These are the results of 417 primary vaccinations against smallpox with MVA, an attenuated vaccine. All of the patients were over three years old. In Europe, this group has an increased risk of postvaccinal encephalitis. The intracutaneous inoculation produced a light local infiltration and only 11.7% showed a light generalized reaction. In order to attain a reliable immunity, a second inoculation was performed one week later, epicutaneously with Elstree-vaccine. The local reaction was in general that of a normal revaccination, and 79.4% of our patients had neither fever nor general symptoms. Among the others no one became seriously ill. We did not observe any complications specific for a smallpox vaccination. In comparison to the other vaccination methods currently used, the MVA "Two-step"-vaccination is probably the safest. Its risk of a postvaccinal encephalitis is supposed to be lower according to animal experiments and theoretical considerations. This hypothesis has been confirmed meanwhile by the results of several thousand vaccinations in the already mentioned age-group.     

An ENO-Based Method for Second-Order Equations and Application to the Control of Dike Levels

This work aims to model the optimal control of dike heights. The control problem leads to so-called Hamilton-Jacobi-Bellman (HJB) variational inequalities, where the dike-increase and reinforcement times act as input quantities to the control problem. The HJB equations are solved numerically with an Essentially Non-Oscillatory (ENO) method. The ENO methodology is originally intended for hyperbolic conservation laws and is extended to deal with diffusion-type problems in this work. The method is applied to the dike optimisation of an island, for both deterministic and stochastic models for the economic growth.