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11.
F Thonney FL Munier A Balmer G Pescia DF Schorderet 《Canadian Metallurgical Quarterly》1996,85(35):1058-1062
Retinoblastoma, a tumor of the immature retina concerns babies and young infants in particular. They make up for 14% of malignomas in the first years of life. There are two types of retinoblastoma: In the first two alleles of the gene Rb1 must be inactivated sequentially in the same retinoblast cell until this may escape control. In this case the retinoblastoma is always unilateral and unifocal. This is explained by the lower frequency of two mutations in one retinoblast. The other type, however, is inherited: One allele Rb1 is inactivated in all cells of the organism by mutation. The probability that a second mutation arrives in different retinoblasts is thus high. In this case bilateral multifocal tumors develop. Characterization of the Rb1 gene has permitted identification or at least determination of a haplotype in persons at risk. This knowledge is decisive for early recognition of babies at risk and for genetic counselling. 相似文献
12.
Rutten PE 《The Review of scientific instruments》2011,82(7):073705
Disclosed is the design of a high speed two-dimensional optical beam position detector which outputs the X and Y displacement and total intensity linearly. The experimental detector measures the displacement from DC to 123 MHz and the intensity of an optical spot in a similar way as a conventional quadrant photodiode detector. The design uses four discrete photodiodes and simple dedicated optics for the position decomposition which enables higher spatial accuracy and faster electronic processing than conventional detectors. Measurements of the frequency response and the spatial sensitivity demonstrate high suitability for atomic force microscopy, scanning probe data storage applications, and wideband wavefront sensing. The operation principle allows for position measurements up to 20 GHz and more in bandwidth. 相似文献
13.
SR Cohen ML Corrigan FL Bookstein CA Trotman A Burdi M Barr 《Canadian Metallurgical Quarterly》1995,6(3):184-189
Trisomy 21 develops as a result of nondisjunction of two homologous chromosomes during either the first or second meiotic division. One of the more important consequences of these genetic alterations is the predictable, although variable disturbance in the architecture of the craniofacial region [1]. Postnatal craniofacial morphology has been extensively studied in Down's syndrome (DS). However, little information is available on human prenatal development of the head and face in such patients. The time at which changes in craniofacial phenotype first emerge in Down's syndrome fetuses and at which physical growth begins to diverge from normal is unknown. To explore these questions, we compared prenatal craniofacial growth in 50 Down's syndrome fetuses with that of 555 fetuses judged to be "typical for body weight and age" using the method of log-linear allometry [2]. 相似文献
14.
OBJECTIVE: Primary aortoenteric fistula is a rare disorder of which only four patients have been reported in the Dutch literature so far. The objective of our study was to obtain more realistic figures on the incidence of this condition, with data on the clinical presentation, diagnostic procedures, treatment and results in a group of patients not previously reported as "case histories". METHODS: A questionnaire was sent to all surgical clinics in The Netherlands. Out of 180 questionnaires, 102 have been returned reporting 27 patients to which data of eight others treated in our own institution were added. RESULTS: In all but one of these 29 patients the fistula was caused by an atherosclerotic aneurysm, the one exception being caused by an ingested cocktail pin. Gastrointestinal haemorrhage was the predominant symptom, being present in 28 of the patients, while the complete triad of haemorrhage, pain and a pulsating mass was found in only eight patients. Twenty-seven patients were treated with an in situ graft of which 14 are doing well at long term follow-up. CONCLUSIONS: Primary aortoenteric fistula is far more common than one would expect from the number of patients reported in literature. A high index of suspicion based on a complete physical examination remains the key to a correct diagnosis. Direct closure of the intestine and in situ grafting of the aorta is the treatment of first choice. 相似文献
15.
Huafeng Yu Abdoulaye Gamatié Éric Rutten Jean-Luc Dekeyser 《Innovations in Systems and Software Engineering》2008,4(3):215-222
In this paper, we use the UML MARTE profile to model high-performance embedded systems (HPES) in the GASPARD2 framework. We address the design correctness issue on the UML model by using the formal validation tools associated with
synchronous languages, i.e., the SIGALI model checker, etc. This modeling and validation approach benefits from the advantages of UML as a standard, and from the
number of validation tools built around synchronous languages. In our context, model transformations act as a bridge between
UML and the chosen validation technologies. They are implemented according to a model-driven engineering approach. The modeling
and validation are illustrated using the multimedia functionality of a new-generation cellular phone. 相似文献
16.
Of 160 patients who underwent Nissen fundoplication for treatment of symptomatic peptic reflux esophagitis, five patients (3.1%) developed gastric ulcers. Four of these five patients experienced the "gas-bloat" syndrome. All ulcers were located on the lesser curvature of the stomach. Analyses of our experience with use of various types of hiatal hernia repair suggests that creation of the valvuloplastic mechanism unique to the Nissen procedure may be of etiologic significance in the development of gastric ulcers following this procedure. 相似文献
17.
Bowfield A Barrett DA Alexander MR Ortori CA Rutten FM Salter TL Gilmore IS Bradley JW 《The Review of scientific instruments》2012,83(6):063503
The authors report on a modified micro-plasma assisted desorption/ionisation (PADI) device which creates plasma through the breakdown of ambient air rather than utilising an independent noble gas flow. This new micro-PADI device is used as an ion source for ambient mass spectrometry to analyse species released from the surfaces of polytetrafluoroethylene, and generic ibuprofen and paracetamol tablets through remote activation of the surface by the plasma. The mass spectra from these surfaces compare favourably to those produced by a PADI device constructed using an earlier design and confirm that the new ion source is an effective device which can be used to achieve ambient mass spectrometry with improved spatial resolution. 相似文献
18.
19.
This study was undertaken to determine the relative effects of morphine and halothane anesthesia on coronary blood flow. Right heart bypass was instituted in 20 dogs by draining the vena cava blood into a cardiotomy reservoir and returning it to the main pulmonary artery. Coronary sinus drainage was measured by a right ventricular cannula. Group I (10 dogs) was sequentially given 0.5, 1, 1.5, 2.0, and 2.5% halothane. Group II (10 dogs) was given 1, 2, 3, 4, and 5 mg per kilogram of morphine intravenously. Arterial pressure, coronary sinus blood flow, cardiac output, arterial pH, PCO2, and PO2 were determined and repeated at each dose level of anesthesia and compared to the control values. Morphine significantly increased coronary flow at 3, 4, and 5 mg/kg without pressure adjustment and at 2 mg/kg after pressure adjustment. Coronary flow with halothane was unchanged from control values except for a decrease at 2.5%. Coronary flow was significantly greater with 3, 4, and 5 mg/kg of morphine than with 1.0 and 1.5% halothane. 相似文献
20.
There are currently about 6 million – mainly older – people with dementia in the European Union. With ageing, a number of sensory changes occur. Dementia syndrome exacerbates the effects of these sensory changes and alters perception of stimuli. People with dementia have an altered sensitivity for indoor environmental conditions, which can induce problematic behaviour with burdensome symptoms to both the person with dementia and the family carer. This paper, based on literature review, provides an overview of the indoor environmental parameters, as well as the integrated design and implementation of relevant building systems. The overview is presented in relation to the intrinsic ageing of senses, the responses of older people with dementia and the impact on other relevant stakeholders through the combined use of the International Classification of Functioning, Disability and Health, and the Model of Integrated Building Design. Results are presented as indicators of the basic value, functional value and economic value, as well as a synthesis of building-related solutions. Results can help designers and building services engineers to create optimal environmental conditions inside the living environments for people with dementia, and can be used to raise awareness among health care professionals about of the influence of the indoor environment on behaviour of the person with dementia. 相似文献