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排序方式: 共有2049条查询结果,搜索用时 46 毫秒
231.
Brian D. Badgley John FergusonAmy Vanden Heuvel Gregory T. KleinheinzColleen M. McDermott Todd R. SandrinJulie Kinzelman Emily A. JunionMuruleedhara N. Byappanahalli Richard L. WhitmanMichael J. Sadowsky 《Water research》2011,45(2):721-731
High concentrations of Escherichia coli in mats of Cladophora in the Great Lakes have raised concern over the continued use of this bacterium as an indicator of microbial water quality. Determining the impacts of these environmentally abundant E. coli, however, necessitates a better understanding of their ecology. In this study, the population structure of 4285 Cladophora-borne E. coli isolates, obtained over multiple three day periods from Lake Michigan Cladophora mats in 2007-2009, was examined by using DNA fingerprint analyses. In contrast to previous studies that have been done using isolates from attached Cladophora obtained over large time scales and distances, the extensive sampling done here on free-floating mats over successive days at multiple sites provided a large dataset that allowed for a detailed examination of changes in population structure over a wide range of spatial and temporal scales. While Cladophora-borne E. coli populations were highly diverse and consisted of many unique isolates, multiple clonal groups were also present and accounted for approximately 33% of all isolates examined. Patterns in population structure were also evident. At the broadest scales, E. coli populations showed some temporal clustering when examined by year, but did not show good spatial distinction among sites. E. coli population structure also showed significant patterns at much finer temporal scales. Populations were distinct on an individual mat basis at a given site, and on individual days within a single mat. Results of these studies indicate that Cladophora-borne E. coli populations consist of a mixture of stable, and possibly naturalized, strains that persist during the life of the mat, and more unique, transient strains that can change over rapid time scales. It is clear that further study of microbial processes at fine spatial and temporal scales is needed, and that caution must be taken when interpolating short term microbial dynamics from results obtained from weekly or monthly samples. 相似文献
232.
Balmer BC Schwacke LH Wells RS George RC Hoguet J Kucklick JR Lane SM Martinez A McLellan WA Rosel PE Rowles TK Sparks K Speakman T Zolman ES Pabst DA 《The Science of the total environment》2011,409(11):2094-2101
Bottlenose dolphins (Tursiops truncatus) are apex predators in coastal southeastern U.S. waters; as such they are indicators of persistent organic pollutants (POPs) in coastal ecosystems. POP concentrations measured in a dolphin's blubber are influenced by a number of factors, including the animal's sex and ranging pattern in relation to POP point sources. This study examined POP concentrations measured in bottlenose dolphin blubber samples (n = 102) from the Georgia, USA coast in relation to individual ranging patterns and specifically, distance of sightings from a polychlorinated biphenyl (PCB) point source near Brunswick, Georgia. Dolphin ranging patterns were determined based upon 5 years of photo-identification data from two field sites approximately 40 km apart: (1) the Brunswick field site, which included the Turtle/Brunswick River Estuary (TBRE), and (2) the Sapelo field site, which included the Sapelo Island National Estuarine Research Reserve (SINERR). Dolphins were categorized into one of three ranging patterns from photo-identification data. Individuals with sighting histories exclusively within one of the defined field sites were considered to have either Brunswick or Sapelo ranging patterns. Individuals sighted in both field sites were classified as having a Mixed ranging pattern. Brunswick males had the highest concentrations of PCBs reported for any marine mammal. The pattern of PCB congeners was consistent with Aroclor 1268, a highly chlorinated PCB mixture associated with a Superfund site in Brunswick. PCB levels in Sapelo males were lower than in Brunswick males, but comparable to the highest levels measured in other dolphin populations along the southeastern U.S. Female dolphins had higher Aroclor 1268 proportions than males, suggesting that the highly chlorinated congeners associated with Aroclor 1268 may not be offloaded through parturition and lactation, as easily as less halogenated POPs. Individuals sighted farther from the Superfund point source had lower Aroclor 1268 proportions. 相似文献
233.
RJ Butterfield JD Sudweeks EP Blankenhorn R Korngold JC Marini JA Todd RJ Roper C Teuscher 《Canadian Metallurgical Quarterly》1998,161(4):1860-1867
Experimental allergic encephalomyelitis (EAE), the principal animal model of multiple sclerosis, is a genetically determined phenotype. In this study, analyses of the cumulative disease frequencies in parental, F1 hybrid, and F2 mice, derived from the EAE-susceptible SJL/J strain and the EAE-resistant B10.S/DvTe strain, confirmed that susceptibility to EAE is not inherited as a simple Mendelian trait. Whole genome scanning, using 150 informative microsatellite markers and a panel of 291 affected and 390 unaffected F2 progeny, revealed significant linkage of EAE susceptibility to marker loci on chromosomes 7 (eae4) and 17, distal to H2 (eae5). Quantitative trait loci for EAE severity, duration, and onset were identified on chromosomes 11 (eae6, and eae7), 2 (eae8), 9 (eae9), and 3 (eae10). While each locus reported in this study is important in susceptibility or disease course, interactions between marker loci were not statistically significant in models of genetic control. One locus, eae7, colocalizes to the same region of chromosome II as Orch3 and Idd4, susceptibility loci in autoimmune orchitis and insulin-dependent diabetes mellitus, respectively. Importantly, eae5 and eae7 are syntenic with human chromosomes 6p21 and 17q22, respectively, two regions of potential significance recently identified in human multiple sclerosis genome scans. 相似文献
234.
235.
Chassin Laurie; Presson Clark C.; Todd Michael; Rose Jennifer S.; Sherman Steven J. 《Canadian Metallurgical Quarterly》1998,34(6):1189
A longitudinal multigenerational design was used to examine the intergenerational transmission of smoking and the correlated transmission of parental support and control. Whether maternal socialization of adolescent smoking (both general parenting practices and smoking-specific strategies) would predict adolescent smoking both directly and indirectly by affecting peer affiliations was tested. There was strong evidence for the intergenerational transmission of cigarette smoking and for the relation between peer smoking and adolescent smoking. Both general parenting practices and smoking-specific discussion and punishment were significantly related to adolescents' smoking, especially for adolescent-reported parenting. Support for the intergenerational transmission of parenting practices emerged only in mothers' reports of support. Results suggest expanding current peer-focused prevention efforts to include parental socialization strategies. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
236.
Todd A. Kuntz Haydn N. G. Wadley David R. Black 《Metallurgical and Materials Transactions A》1993,24(5):1117-1124
An X-ray technique for the measurement of internal residual strain gradients near the continuous reinforcements of metal matrix
composites has been investigated. The technique utilizes high intensity white X-ray radiation from a synchrotron radiation
source to obtain energy spectra from small (10-3 mm3) volumes deep within composite samples. The energy peak positions satisfy Bragg’s law and allow determination of the lattice
parameter. As the probe volume is translated, the peaks of the spectra shift and are used to infer lattice spacing changes
and thus strains with a precision of 10-3 to 10-4 (depending on the sample grain size/probe volume ratio). The viability of the technique has first been tested using a model
system with 800 μm A12O3 fibers and a commercial purity titanium matrix. For this system (which remained elastic on cooling), good agreement was observed
between the measured residual radial and hoop strain gradients and those estimated from a simple elastic concentric cylinders
model. The technique was then used to assess the strains near (SCS-6) silicon carbide fibers in a Ti-14Al-21Nb matrix after
consolidation processing. Reasonable agreement between measured and calculated strains was seen provided the probe volume
was located 50 μm or more from the fiber/matrix interface. Close to the interface, the measured elastic strains were smaller
than anticipated, due to relaxation of the residual stress by plasticity and radial cracking during sample cooling.
Formerly Graduate Student, Department of Materials Science, University of Virginia, Charlottesville 相似文献
237.
Buss David M.; Haselton Martie G.; Shackelford Todd K.; Bleske April L.; Wakefield Jerome C. 《Canadian Metallurgical Quarterly》1998,53(5):533
Adaptation and natural selection are central concepts in the emerging science of evolutionary psychology. Natural selection is the only known causal process capable of producing complex functional organic mechanisms. These adaptations, along with their incidental by-products and a residue of noise, comprise all forms of life. Recently, S. J. Gould (1991) proposed that exaptations and spandrels may be more important than adaptations for evolutionary psychology. These refer to features that did not originally arise for their current use but rather were co-opted for new purposes. He suggested that many important phenomena—such as art, language, commerce, and war—although evolutionary in origin, are incidental spandrels of the large human brain. The authors outline the conceptual and evidentiary standards that apply to adaptations, exaptations, and spandrels and discuss the relative utility of these concepts for psychological science. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
238.
Todd Swanstrom 《Journal of Urban Affairs》1993,15(1):55-78
ABSTRACT: Urban political economy has been prone to two errors: overgeneralizing to abstract theory and overemphasizing the role of economic interests. Drawing on postmodern philosophy, the author examines these two errors, which he labels economism, and suggests a more concrete culturally rooted approach to urban political economy. The author develops his argument through a critique of the conventional concept of urban economic restructuring. Far from being a unified global process, urban economic restructuring is, in fact, highly fragmented and rooted in particular political and cultural relations. Geographically rooted political and cultural loyalties are not drags on economic growth but are essential, the author argues, for a well-functioning economy. The paper concludes with some policy implications for the problem of concentrated urban poverty. 相似文献
239.
240.
LJ Conley TJ Bush SP Buchbinder KA Penley FN Judson SD Holmberg 《Canadian Metallurgical Quarterly》1996,10(10):1121-1126
OBJECTIVE: To clarify the effect of cigarette smoking on the development of conditions associated with HIV infection. DESIGN: Prospective and retrospective cohort study, with interview and examination twice a year since 1988. METHODS: Data on 516 HIV-infected men from cohorts of homosexual and bisexual men in San Francisco, Denver and Chicago, who were repeatedly interviewed and examined between 1988 and 1992, were analysed. After excluding men who did not have well-defined dates of seroconversion and those who were classified as ex- or intermittent smokers, 232 men remained for analysis: 106 were smokers and 126 were non-smokers. Univariate and Kaplan-Meier survival analyses were performed to assess the relationship between cigarette smoking and loss of CD4+ T-lymphocytes, diagnosis of any AIDS-defining illness, and specific diagnosis of Kaposi's sarcoma, Pneumocystis carinii pneumonia (PCP), oral candidiasis, hairy leukoplakia, and community-acquired pneumonia. RESULTS: By univariate analyses, cigarette smoking was not associated with clinical AIDS, loss of CD4+ cells, Kaposi's sarcoma or PCP, but was significantly associated with oral candidiasis [relative risk (RR), 1.32; 95% confidence interval (CI), 1.02-1.70], hairy leukoplakia (RR, 1.51; 95% CI, 1.15-1.99), and community-acquired pneumonia (RR, 2.62; 95% CI, 1.30-5.27). Dose-response effect was also evident for these three conditions (all P < 0.01). Kaplan-Meier survival analysis indicated no association between cigarette smoking and time of progression to clinical AIDS, Kaposi's sarcoma (KS), or PCP (P = 0.62, 0.54 and 0.11, respectively) but showed that cigarette smokers developed oral candidiasis, hairy leukoplakia, and pneumonia more quickly than non-smokers (P = 0.031, 0.006 and 0.009, respectively). CONCLUSIONS: Cigarette smoking was not associated with an increased likelihood or rate of developing KS, PCP or AIDS, but was associated with developing community-acquired pneumonia, oral candidiasis, and hairy leukoplakia in these HIV-infected men. 相似文献