Biologic effects of 17 alpha-dihydroequilin sulfate

OBJECTIVE: To determine the independent biologic effects of 17 alpha-dihydroequilin sulfate. DESIGN: Prospective randomized study. SETTING: University of Southern California Medical Center. PATIENTS(S): Twenty-one postmenopausal women, mean age 50 +/- 2 (+/-SEM) years, and mean body mass index 27 +/- 2. INTERVENTION(S): Women were randomized to receive daily oral doses of either 1.25 mg of estrone sulfate (E1S), 0.2 mg of 17 alpha-dihydroequilin sulfate, or a combination. Three blood and urine samples were obtained before and after 30 and 90 days of treatment. RESULT(S): After 30 and 90 days of treatment, E1S alone increased sex hormone-binding globulin (SHBG) levels significantly, 19.7% +/- 6.0% and 61.3% +/- 13.0%, whereas 17 alpha-dihydroequilin sulfate reduced SHBG levels, 20.8% +/- 68% and 12.4% +/- 7.5%, respectively. Nevertheless, the combination of E1S and 17 alpha-dihydroequilin sulfate significantly increased SHBG levels, 103% +/- 27.9% and 98.2% +/- 19.1%, compared with baseline at 30 and 90 days. Fewer changes were evident with corticosteroid-binding globulin (CBG). After 90 days of treatment, CBG levels significantly increased 30.9% +/- 5.5% with E1S, decreased by 7.2% +/- 5.0% with 17 alpha-dihydroequilin sulfate, and, with the combination, significantly increased by 10.5% +/- 2.4% compared with baseline. Changes in lipids and lipoproteins were more variable. However, high-density-lipoprotein cholesterol increased significantly with E1S at 30 and 90 days compared with baseline, 96.5% +/- 39% and 91.5% +/- 22.6%, and with the combination increased 66.4% +/- 13.3% and 79.2% +/- 24.4%, respectively. Fewer changes were evident with 17 alpha-dihydroequilin sulfate alone, decreasing 4.4% +/- 22% and 2.6% +/- 21.3%. Urinary ratios of bone collagen equivalents-creatinine and calcium-creatinine decreased in all three groups. However, the combination group resulted in a significantly greater percentage decrease in bone collagen equivalents-creatinine than with E1S alone. CONCLUSIONS(S): 17 alpha-Dihydroequilin sulfate could modify some of the first-pass effects of conjugated equine estrogens and act synergistically with other conjugated equine estrogens to reduce bone resorption.     

Improving the social behavior and peer acceptance of rejected boys: Effects of social skill training with instructions and prohibitions.

Thirty-two boys who were rejected by their peers in Grades 1–3 were identified on the basis of negative sociometric nominations and negative social behavior. They were randomly assigned to one of four treatment conditions: (a) instructions to promote positive social behavior, (b) prohibitions to reduce negative social behavior, (c) a combination of instructions and prohibitions, or (d) no treatment. Interventions were applied during 10 half-hour school play sessions. Behavioral observations and peer and teacher ratings were collected prior to treatment, immediately after treatment, and at a follow-up assessment 6 weeks after treatment. Additional peer and teacher ratings were collected at a 1-year follow-up. Prohibitions combined with a response cost for negative behaviors resulted in immediate and stable declines in negative behavior and led to temporary increases in positive responses received from peers. Instructions and the reinforcement of specific social skills promoted sustained positive peer interactions 6 weeks after treatment. Only the combination of instructions and prohibitions led to improved sociometric ratings from nontarget treatment partners. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Application of the SRIF to systems with time delay

Square-root information falter formulations of the discrete-time Kalman filter are sometimes thought to be restricted by a requirement that the state transition matrix be nonsingular. In a recent publication [1], Boncelet, Jr. and Dickinson have shown that this restriction is not necessary. For problems where both formulations can be applied, the generalized formulation is, however, more computation intensive than the direct formulation described by Bierman [2]. Also, it is shown here that transition singularities associated with time delays are removable and can be efficiently handled in the SRIF.     

Examining clinical judgment in an adaptive intervention design: The fast track program.

Although clinical judgment is often used in assessment and treatment planning, rarely has research examined its reliability, validity, or impact in practice settings. This study tailored the frequency of home visits in a prevention program for aggressive- disruptive children (n = 410; 56% minority) on the basis of 2 kinds of clinical judgment: ratings of parental functioning using a standardized multi-item scale and global assessments of family need for services. Stronger reliability and better concurrent and predictive validity emerged for the 1st kind of clinical judgment than for the 2nd. Exploratory analyses suggested that using ratings of parental functioning to tailor treatment recommendations improved the impact of the intervention by the end of 3rd grade but using more global assessments of family need did not. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Functional MR of frontal lobe activation: comparison with Wada language results

PURPOSE: Our purpose was to determine the utility of functional MR imaging in conjunction with a word-generation paradigm in the assessment of language lateralization. METHODS: Functional MR imaging and Wada testing for language lateralization was performed in patients with complex partial seizures during the performance of word-generation tasks. A language lateralization quotient was calculated from the number of activated pixels in the right and left hemispheres. A language laterality score was derived from the Wada results as the percentage of correct responses during right internal carotid artery injection minus the percentage of correct responses during left internal carotid injection. A correlation coefficient between the functional MR imaging results and the Wada language laterality scores was calculated. RESULTS: In 13 patients, hemispheric dominance based on Wada testing was confirmed by functional MR imaging during silent word generation. The Wada laterality scores varied from 100 to -100 and the functional MR imaging scores varied from 100 to -10. The language lateralization scores determined by functional MR imaging correlated significantly with the language lateralization scores derived from Wada testing. CONCLUSION: Functional MR imaging performed during word generation is an accurate method for lateralizing language function in patients with complex partial epilepsy.     

Voyager orbit determination at Jupiter

This paper summarizes the Voyager 1 and Voyager 2 orbit determination activity extending from encounter minus 60 days to the Jupiter encounter, and includes quantitative results and conclusions derived from mission experience. The major topics covered include an identification and quantification of the major orbit determination error sources and a review of salient orbit determination results from encounter, with emphasis on the Jupiter approach phase orbit determination. Special attention is paid to the use of combined spacecraft-based optical observations and Earth-based radiometric observations to achieve accurate orbit determination during the Jupiter encounter approach phase.