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1.
J Westhuyzen AD Cochrane PJ Tesar T Mau DB Cross MP Frenneaux FA Khafagi SJ Fleming 《Canadian Metallurgical Quarterly》1997,113(5):942-948
Augmentation of antioxidant defenses may help protect tissues against ischemia-reperfusion injury associated with operations involving cardiopulmonary bypass. In this study we examined the effect of pretreating patients with alpha-tocopherol (vitamin E) and ascorbic acid (vitamin C) or placebo on injury to the myocardium. Seventy-six subjects undergoing elective coronary artery bypass grafting participated in a prospective, double-blind, placebo-controlled randomized trial, receiving either placebo or both 750 IU dl-alpha-tocopherol per day for 7 to 10 days and 1 gm ascorbic acid 12 hours before the operation. Plasma alpha-tocopherol concentrations, raised fourfold by supplementation, fell by 70% after the operation in the supplemented group and to negligible levels in the placebo group. There were no significant differences between the groups with respect to release of creatine kinase MB isoenzyme over 72 hours, nor in the reduction of the myocardial perfusion defect determined by thallium 201 uptake. Electrocardiography provided no evidence of a benefit from antioxidant supplementation. Thus the supplementation regimen prevented the depletion of the primary lipid soluble antioxidant in plasma, but provided no measurable reduction in myocardial injury after the operation. 相似文献
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A remarkably good correlation between the rate of proton transfer from excited protonated 1-aminopyrene and the gas phase basicities of the organic component in water: organic solvent binary mixtures has been found. We suggest that use of anilinium acids minimizes the effect of anion solvation and Coulomb interactions and enables the influence of the organic cosolvent on the proton transfer to be clearly observed. The model proposed is one in which the proton is always transferred to a water molecule and a concerted proton transfer to a water molecule solvated by the organic cosolvent also occurs. The cosolvent influence is then on this latter species via hydrogen bond interactions. The correlation holds in pure water but not in pure organic solvents where, clearly, the proton must be transferred to the organic molecule. 相似文献
4.
Comparison of Markov model and fault tree approach in determining initiating event frequency for systems with two train configurations 总被引:1,自引:0,他引:1
This study explores the use of Markov models in some areas of systems analysis in which time evolution of the system may be a significant factor in influencing the system reliability or availability. Comparisons are made between the Markov models and the time-averaged fault tree models for determining support system failure initiating event frequency in a nuclear power plant, for both power and shutdown conditions. Factors affecting consistency between the fault tree approach and the Markov model approach are studied for systems with common two train configurations. A correlation is developed to estimate the ratio between initiator frequencies through both approaches for a two parallel component system. Insights are developed as to when time averaged and simplified fault tree models support a good approximation to the more rigorous time-dependent Markov models. 相似文献
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The letter describes the properties of the two most useful definitions of the mode field radius of a single-mode optical fibre when they are evaluated in the presence of noise for both near-field and far-field measurements. 相似文献
7.
A national effort, begun in 1972 to increase the numbers of minorities in engineering, has made substantial progress, but the attrition for minority students is still estimated at 70%. To address the problem, Project Preserve was designed to confirm, by demonstration, the results of previous research showing that the combination of explicit cognitive development, close relationships with faculty, and strong bonds to an institution can raise the performance and retention of minority engineering students. The project enrolled over 100 minority engineering students who had been dismissed from freshman engineering studies on other campuses or placed on academic probation, but whose high school grades and SAT scores were indicative of success. They were channeled into participating institutions chosen for their record of basic support services, willingness to augment or restructure those services, and for variation among institutional variables: Xavier University of Louisiana (XU), California State University at Northridge (CSUN), and City College of the City University of New York (CCNY). A 2 1/2 hour battery of evaluation instruments was given to 79 students upon entry and to 26 students upon their attaining Junior status after two years in the program. The results demonstrated that: (1) an admirable 64% of would-be drop outs had achieved Junior status or were still enrolled in engineering at the conclusion of two years; (2) cognitive growth occurred on basic memory skills and one critical thinking skill, but there were institutional differences in the extent of intellectual development, with Xavier producing the most change; (3) closer relationships to faculty were outcomes; (4) the most positive feelings about, or bonding to, the institution occurred at Xavier University, while the most evidence of social participation and connectedness occurred at CSUN. 相似文献
8.
On the Evolutionary Optimization of Many Conflicting Objectives 总被引:2,自引:0,他引:2
This study explores the utility of multiobjective evolutionary algorithms (using standard Pareto ranking and diversity-promoting selection mechanisms) for solving optimization tasks with many conflicting objectives. Optimizer behavior is assessed for a grid of mutation and recombination operator configurations. Performance maps are obtained for the dual aims of proximity to, and distribution across, the optimal tradeoff surface. Performance sweet-spots for both variation operators are observed to contract as the number of objectives is increased. Classical settings for recombination are shown to be suitable for small numbers of objectives but correspond to very poor performance for higher numbers of objectives, even when large population sizes are used. Explanations for this behavior are offered via the concepts of dominance resistance and active diversity promotion. 相似文献
9.
AF Fleming 《Canadian Metallurgical Quarterly》1996,347(9015):1634-1635
10.
M Tristam AS Alaamer JS Fleming VJ Lewington MA Zivanovic 《Canadian Metallurgical Quarterly》1996,37(6):1058-1063
In the treatment of neural crest tumors, such as pheochromocytoma, with[131I]MIBG, bone marrow toxicity limits the amount of administered activity and, thus, a therapeutically useful tumor dose. METHODS: We calculated tumor doses in a series of diagnostic studies with [123I]MIBG using accurate quantification of SPECT and planar scintigraphy. By extrapolating diagnostic results to therapeutic activities of [131I]MIBG, we could compare the results with whole-body doses from a series of therapies. RESULTS: The tumor dose was DT = 2.2 mGy MBq(-1) (median value of 27 measurements, range 0.04 < or = DT < or = 20 mGy MBq(-1) and the whole-body dose in a series of 16 patients undergoing 50 therapies was DWB = 0.12 +/- 0.04 mGy MBq(-1) (mean +/- s.d.). The therapeutic ratio varied between 130 to below 10 in some patients. CONCLUSION: The results were compared with published data. We found clearly skewed distribution of tumor doses, with a majority of tumors receiving only a few mGy per MBq administered activity. In some patients, however, doses did reach 20 mGy MBq(-1). 相似文献