Experimental observations of chemical and thermal gradients in an experimental BOF

The objective of this investigation was to determine the chemical and thermal gradients during steel making in a pilot size basic oxygen furnace. It was postulated that if these gradients could be determined under different conditions, conflicting theories of operation could be tested and optimum operating conditions would be indicated. New sample probe techniques were developed in which the probes are inserted through the side of the vessel to desired locations. Shortly after reaching the desired locations, the tip of an evacuated tube inside the probe opens and delivers metal to the other end of the probe outside the vessel. Temperatures were determined throughout the bath by specially reinforced but sensitive thermocouple probes. Important differences in both chemical and thermal gradients were found. The gradients were greatest with shallow penetration of the jet-for example after 3 min in a heat with about 1 in. penetration, the P content varied from 0.05 to 0.17 pct, silicon from 0.05 to 0.20 pct and the temperature from 2500° to 2900° F. These variations were found in a bath only 6 in. deep and 15 in. diam. By contrast, with deeper jet penetration to the center of the bath, the gradients were greatly reduced. Regardless of the operating conditions employed, the data indicate a metal circulation pattern which is upward from the jet cavity and radially outward at the surface. Even more important, by inserting a spray collector above the bath, it was found that with hard blowing the jet pumps out a volume of droplets during a heat which is equal to the bath volume. These droplets are rapidly oxidized,e.g. from 3.6 to 0.4 pct C, in their flight above the bath and are an important consideration in refining.     

Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir

Despite recent advances in the application of data-dependent liquid chromatography/tandem mass spectrometry (LC/MS/MS) to the identification of drug metabolites in complex biological matrixes, a prior knowledge of the likely routes of biotransformation of the therapeutic agent of interest greatly facilitates the detection and structural characterization of its metabolites. Thus, prediction of the [M + H]+ m/z values of expected metabolites allows for the construction of user-defined MS(n) protocols that frequently reveal the presence of minor drug metabolites, even in the presence of a vast excess of coeluting endogenous constituents. However, this approach suffers from inherent user bias, as a result of which additional "survey scans" (e.g., precursor ion and constant neutral loss scans) are required to ensure detection of as many drug-related components in the sample as possible. In the present study, a novel approach to this problem has been evaluated, in which knowledge-based predictions of metabolic pathways are first derived from a commercial database, the output from which is used to formulate a list-dependent LC/MS(n) data acquisition protocol. Using indinavir as a model drug, a substructure similarity search on the MDL metabolism database with a similarity index of 60% yielded 188 "hits", pointing to the possible operation of two hydrolytic, two N-dealkylation, three N-glucuronidation, one N-methylation, and several aromatic and aliphatic oxidation pathways. Integration of this information with data-dependent LC/MS(n) analysis using an ion trap mass spectrometer led to the identification of 18 metabolites of indinavir following incubation of the drug with human hepatic postmitochondrial preparations. This result was accomplished with only a single LC/MS(n) run, representing significant savings in instrument use and operator time, and afforded an accurate view of the complex in vitro metabolic profile of this drug.     

Pavlovian appetitive contingencies and approach versus withdrawal to conditioned stimuli in pigeons.

Investigated the directed skeletal movements of 21 female White Carneaux pigeons toward signals of food or no food in 3 experiments. Ss approached and pecked an illuminated key that was positively correlated with food delivery, and positioned themselves relatively far from an illuminated key that was negatively correlated with food delivery. Key illuminations alone, random presentations of key illuminations and food, and backward pairings of key illuminations and food did not produce keypecking or consistent approach-withdrawal. Therefore, directed skeletal behavior-often believed to be conditioned and maintained primarily or exclusively by operant procedures-also emerges on Pavlovian procedures. Several kinds of alternative explanations (e.g., conditioned reinforcement effects, and stimulus substitution) for these phenomena are considered, and some potential implications for operant discrimination learning are briefly explored. (17 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Securing the Operating System: Does lesser-known mean less at risk? Is the OS an example of security though obscurity?

It is no secret that Microsoft Windows NT is the hacker’s favourite Operating System (OS). According to defacement-tracking site Attrition.org, (www.Attrition.org) Windows NT received 54.41% of all recorded OS attacks between August 1999 and April 2001. In stark contrast, some of the lesser-known Operating Systems made up for as little as 0.1% of all OS attacks. However, despite the huge difference in the quantity of attacks, companies that employ the lesser-known systems may be at greater risk…     

Comparison of data gap-filling methods for Landsat ETM+ SLC-off imagery for monitoring forest degradation in a semi-deciduous tropical forest in Mexico

A number of methods to overcome the 2003 failure of the Landsat 7 Enhanced Thematic Mapper (ETM+) scan-line corrector (SLC) are compared in this article in a forest-monitoring application in the Yucatan Peninsula, Mexico. The objective of this comparison is to determine the best approach to accomplish SLC-off image gap-filling for the particular landscape in this region, and thereby provide continuity in the Landsat data sensor archive for forest-monitoring purposes. Four methods were tested: (1) local linear histogram matching (LLHM); (2) neighbourhood similar pixel interpolator (NSPI); (3) geostatistical neighbourhood similar pixel interpolator (GNSPI); and (4) weighted linear regression (WLR). All methods generated reasonable SLC-off gap-filling data that were visually consistent and could be employed in subsequent digital image analysis. Overall accuracy, kappa coefficients (κ), and quantity and allocation disagreement indices were used to evaluate unsupervised Iterative Self-Organizing Data Analysis (ISODATA) land-cover classification maps. In addition, Pearson correlation coefficients (r) and root mean squares of the error (RMSEs) were employed for estimates agreement with fractional land cover. The best results visually (overall accuracy > 85%, κ < 9%, quantity disagreement index < 5.5%, and allocation disagreement index < 12.5%) and statistically (r > 0.84 and RMSE < 7%) were obtained from the GNSPI method. These results suggest that the GNSPI method is suitable for routine use in reconstructing the imagery stack of Landsat ETM+ SLC-off gap-filled data for use in forest-monitoring applications in this type of heterogeneous landscape.     

Sex-and age-related differences in ceramide dihexosides of primary human brain tumors

Neutral glycolipids (NGL) are promising diagnostic markers of human gliomas, but differences in NGL with age and sex have not been examined. Previous work demonstrated that ceramide dihexosides (CDH) levels in mouse kidney are age- and sex-dependent, probably due to levels of sex hormones. We quantitated CDH in 181 human gliomas and found significant differences with sex and age, particularly menopause and male puberty. This emphasizes the importance of assessing results of studies on glycolipids in disease states with respect to age and sex in order to avoid erroneous conclusions concerning the relationship of glycolipid composition with diagnosis and pathogenesis.     

Isolation of a novel Helicobacter species, Helicobacter cholecystus sp. nov., from the gallbladders of Syrian hamsters with cholangiofibrosis and centrilobular pancreatitis

A filamentous, gram-negative, motile bacterium with a single polar sheathed flagellum was isolated from gallbladders of hamsters with cholangiofibrosis and centrilobular pancreatitis. Bacteria grew under microaerophilic conditions at 37 and 42 degrees C, were oxidase, catalase, arginine aminopeptidase, and L-arginine arylamidase positive, reduced nitrate to nitrite, were resistant to cephalothin, and exhibited intermediate susceptibility to nalidixic acid. Sequence analysis of the 16S rRNA gene indicated that the bacterium was a novel member of the Helicobacter genus, most closely related to Helicobacter pametensis. We propose to name this bacterium Helicobacter cholecystus. In epidemiologic studies, isolation of H. cholecystus correlated strongly with the presence of cholangiofibrosis and centrilobular pancreatitis; however, further studies are needed to define the role of this bacterium in pathogenesis.     

甲烷市场化合作计划——煤矿煤层气项目开发的机遇

煤矿煤层气的排放是全球甲烷排放的一个重要来源，“甲烷市场化合作计划”的发起是为了识别并开发相关的工程项目，减少煤矿、垃圾填埋场和石油天然气系统等各领域中的甲烷排放。煤矿煤层气项目是“甲烷市场化合作计划”的三个核心领域之一，对推动煤炭行业的甲烷减排发挥重要作用。     

Voronoi diagrams with barriers and on polyhedra for minimal path planning

Two generalizations of the Voronoi diagram in two dimensions (E²) are presented in this paper. The first allows impenetrable barriers that the shortest path must go around. The barriers are straight line segments that may be combined into polygons and even mazes. Each region of the diagram delimits a set of points that have not only the same closest existing point, but have the same topology of shortest path. The edges of this diagram, which has linear complexity in the number of input points and barrier lines, may be hyperbolic sections as well as straight lines. The second construction considers the Voronoi diagram on the surface of a convex polyhedron, given a set of fixed source points on it. Each face is partitioned into regions, such that the shortest path to any goal point in a given region from the closest fixed source point travels over the same sequence of faces to the same closest point.