Reduced performance of male and female athletes at 580 m altitude

Patients with craniocervical mandibular (TMD) disorders can present with tinnitus as a primary or secondary complaint. The embryology and functional anatomy of the middle ear, temporomandibular joint, muscles of mastication and associated tendons, ligaments, blood vessels, nerves and lymphatics was found to be helpful in establishing etiologic concepts which relate tinnitus to these temporomandibular disorders. In addition to etiologic concepts, treatment modalities are described. The authors relate their experiences as well as those of others with different patient populations.     

Effects of TCDD on Ah receptor, ARNT, EGF, and TGF-alpha expression in embryonic mouse urinary tract

Lipoprotein(a) [Lp(a)] biogenesis was examined in primary cultures of hepatocytes isolated from mice transgenic for both human apolipoprotein(a) [apo(a)] and human apoB. Steady-state and pulse-chase labeling experiments demonstrated that newly synthesized human apo(a) had a prolonged residence time (approximately 60 min) in the endoplasmic reticulum (ER) before maturation and secretion. Apo(a) was inefficiently secreted by the hepatocytes and a large portion of the protein was retained and degraded intracellularly. Apo(a) exhibited a prolonged and complex folding pathway in the ER, which included incorporation of apo(a) into high molecular weight, disulfide-linked aggregates. These folding characteristics could account for long ER residence time and inefficient secretion of apo(a). Mature apo(a) bound via its kringle domains to the hepatocyte cell surface before appearing in the culture medium. Apo(a) could be released from the cell surface by apoB-containing lipoproteins. These studies are consistent with a model in which the efficiency of post-translational processing of apo(a) strongly influences human plasma Lp(a) levels, and suggest that cell surface assembly may be one pathway of human Lp(a) production in vivo. Transgenic mouse hepatocytes thus provide a valuable model system with which to study factors regulating human Lp(a) biogenesis.     

Modulation of cardiac sodium current by alpha1-stimulation and volatile anesthetics

BACKGROUND: Alpha1-adrenoceptor stimulation is known to produce electrophysiologic changes in cardiac tissues, which may involve modulations of the fast inward Na+ current (I(Na)). A direct prodysrhythmic alpha1-mediated interaction between catecholamines and halothane has been demonstrated, supporting the hypothesis that generation of halothane-epinephrine dysrhythmias may involve slowed conduction, leading to reentry. In this study, we examined the effects of a selective alpha1-adrenergic receptor agonist, methoxamine, on cardiac I(Na) in the absence and presence of equianesthetic concentrations of halothane and isoflurane in single ventricular myocytes from adult guinea pig hearts. METHODS: I(Na) was recorded using the standard whole-cell configuration of the patch-clamp technique. Voltage clamp protocols initiated from two different holding potentials (V(H)) were applied to examine state-dependent effects of methoxamine in the presence of anesthetics. Steady state activation and inactivation and recovery from inactivation were characterized using standard protocols. RESULTS: Methoxamine decreased I(Na) in a concentration- and voltage-dependent manner, being more potent at the depolarized V(H). Halothane and isoflurane interacted synergistically with methoxamine to suppress I(Na) near the physiologic cardiac resting potential of -80 mV. The effect of methoxamine with anesthetics appeared to be additive when using a V(H) of -110 mV, a potential where no Na+ channels are in the inactivated state. Methoxamine in the absence and presence of anesthetics significantly shifted the half maximal inactivation voltage in the hyperpolarizing direction but had no effect on steady-state activation. CONCLUSION: The present results show that methoxamine (alpha1-adrenergic stimulation) decreases cardiac Na+ current in a concentration- and voltage-dependent manner. Further, a form of synergistic interaction between methoxamine and inhalational anesthetics, halothane and isoflurane, was observed. This interaction appears to depend on the fraction of Na+ channels in the inactivated state. (Key words: Anesthetics, volatile: halothane; isoflurane; methoxamine. Patch clamp: whole-cell configuration; sodium current; ventricular guinea pig myocytes.)     

Nickel Plating for Improved Electrical Contact to Aluminum

A plating for electrical contact surfaces should be selected on the bases of acceptable electrical characteristics (in conjunction with common contact surfaces) and of adequate corrosion resistance in the anticipated environments. One of the problem electrical interfaces which must be considered is between the selected plating and nonplated aluminum contact surfaces.     

Predictive validity of situational assessment at a psychiatric rehabilitation center.

Used situational assessment to predict employment outcomes for 77 individuals (mean age 24.5 yrs) attending a community psychiatric rehabilitation program. The assessment form was a 22-item checklist comprised of 4 dimensions: work readiness, work attitudes, interpersonal relations, and work quality. Ratings were made in 2 work settings: prevocational work crews and transitional employment. Situational assessment predicted outcome better than did work history. Staff ratings were significantly higher for Ss working in transitional employment, although ratings made in both settings were predictive of later employment outcomes. It is concluded that situational assessment may be a method better suited for screening out members who have poor work potential than selecting members who will definitely succeed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Examining the ecological consequences of restoring flow intermittency to artificially perennial lowland streams: Patterns and predictions from the Broken—Boosey creek system in northern Victoria,Australia

The reinstatement of natural flow regimes is a rapidly emerging issue in river restoration worldwide. In northern Victoria, Australia, efforts are presently underway to restore a natural, intermittent flow regime to several streams which have received perennial diversions for both irrigation and stock and domestic water‐supplies for over 100 years. A pipeline to deliver water to landholders will significantly reduce transmission losses throughout the system allowing irrigation canals and diversion weirs to be decommissioned. The motivation for flow alteration in this system lies primarily in reducing inefficiencies in water delivery which, in turn, will be used to meet escalating demands on water resources. The ecological impact of the flow regime shift on these streams is likely to be substantial. This study utilized an existing artificial hydrological gradient (from perennial to intermittent) in two creek systems, to explore relationships between flow regime and a range of ecological variables. These data provide a benchmark against which to assess ecological changes once flow has been altered and form the basis for predicting changes that can assist future management decisions. Data collected from 10 sites across a strong hydrological gradient detected clear differences in geomorphology, water quality and biotic assemblages (macrophytes, macroinvertebrates and fish). By examining the relationship between flow regime and the distribution of biota we identify both the positive and negative outcomes of restoring naturally intermittent flow regimes within artificially perennial lowland streams. The reinstatement of intermittent flow regimes in artificially perennial streams will continue in many parts of the world as water delivery via these systems becomes increasingly uneconomical. While flow restoration may in principle be regarded as a positive step, these findings emphasize the need to consider fully the ecological consequences of restoring historical hydrological regimes to streams within the context of other human induced catchment disturbances. Copyright © 2009 John Wiley & Sons, Ltd.     

Fatty Acids Released from Milk Fat by Lipoprotein Lipase and Lipolytic Psychrotrophs

ABSTRACT: The ability of 13 different strains of psychrotrophs to release free fatty acids in milk was evaluated by using GC analysis. The 13 strains could be categorized into 3 groups: Group 1 consisted of bacteria that grew well and released large quantities of free fatty acids, group 2 consisted of bacteria that grew well but released low amounts of free fatty acids, and group 3 consisted of bacteria that did not grow well nor released large quantities of fatty acids. In group 1, 3 strains were determined to be highly lipolytic, releasing short‐chain fatty acids in amounts greater than reported threshold values. Group 3 consisted of 2 strains, which did not grow well in heat‐treated milk, and the subsequent release of free fatty acids was minor during the 10‐d monitoring time. The other 8 strains tested showed no specific pattern of fatty acid release and quantities of short‐chain fatty acids were not large, despite the ability to grow to high numbers in the treated milk. This work indicates that the lipolytic activity of psychrotrophs common in raw milk is specific to the species and a general prediction of free fatty acid release may not be possible.