Measurement of thrombus formation on intravascular catheters

War is a complex social situation due to the interplay of multiple factors. Economical and political ones are of utmost importance, but human attitudes and motivations must be also taken into account. Being desirable to modify human transactions in such a way that they do not interfere with the basic right of everyone to a condition of physical and mental well-being, war must be abolished. The author contends that an understanding of behaviour through Psychology can be helpful in that aim. Aggression is considered the principal psychological cause of war. It is worth while to differentiate between aggression as an instrument for attaining a special end, and as pure hostility. Only in the first form, it is held here, does it play an important role in war. Psychogists must deal also with a wide range of states of mind that can be "served" by aggression: feelings of inferiority or insecurity, fear, greed, projections, compensations, rationalizations, etc. Scientific approach is not the only one Physiology brings to war prevention. It is equally important the wide dissemination of its conclusions among the general public. Information on the dynamics that prompt people to decide war would make it easier to control. This applies not only to political or military leaders, but also to civil populations. Concerning those two possible contributions of psychologists, scientific and educative, it is suggested the extensive use of psychodramatic techniques. Their richness lie in the lifelike experiences they convey to the participants, and particular aptitude to promote changes of attitudes. Investigation and information on the psychological processes related to war should be undertaken by international organizations of social scientists, acting simultaneously in several countries. Some of the initial steps they could further: 1) that prevention of war be a current subject matter in psychological courses; 2) that the World Health Organization take interest in this subject; 3) that psychologists participate in international political and economical bodies in order to clarify the psychological factors leading to war.     

Innovative methodology to improve the quality of electronic engineering formation through teaching industrial computer engineering

An innovative educational methodology adapted to the requirements of a new era with new societal and industrial challenges for electronic engineers is proposed in this paper. This active methodology, known as the Educational Innovation Project (EIP), is being studied in the Electronic Engineering (EE) degree of the Higher Technical School of Design Engineering at the Polytechnic University of Valencia, Valencia, Spain. The main objective of the EIP methodology is to improve the process of teaching and learning in order to increase student success. To accomplish this objective, the EIP method addresses various issues. From an organizational viewpoint, different structural aspects of the EE degree have been adapted, such as balancing and integrating lectures and laboratory sessions, advancing into interdisciplinary studies coordinated among all the subjects of the course, and strengthening the work in teams to tackle real engineer problems. The industrial computer engineering (ICE) subject is taken as a reference to show how these aspects have been applied. Regarding the faculty, lecturers participate in an open and permanent process of further training; attitudes toward cooperation and exchanges of experience among them are promoted; and research and reflection on new methodologies is encouraged. One of the challenges of the implementation of the EIP project is the development of multidisciplinary projects by team workers. The knowledge acquired from all the subjects is put into practice through the development of a common project to undertake real engineering problems.     

Effect of Proximity and Dimension of Two Artificial Pitting Holes on the Fatigue Endurance of Aluminum Alloy AISI 6061-T6 Under Rotating Bending Fatigue Tests

This work deals with the study of the two artificial pitting holes effects, caused by their dimensions and proximity, on the fatigue endurance of aluminum alloy AISI 6061-T6 under rotating bending fatigue tests. Stress concentration induced by artificial pitting holes is analyzed and correlated with the experimental fatigue life. It is found that the stress concentration increases exponentially when the two pitting holes approach, and this induces an important reduction in the fatigue life. Concerning the diameter variation of one pitting in regard to the second, no important influence was observed on fatigue life for a given separation between them; this implies that the separation between the two artificial pitting holes and the associated stress concentration is the principal parameter on the fatigue life under these conditions. Finally, results are discussed and conclusions are presented involving the fatigue life, proximity, and dimension of pitting holes, stress concentration factor, and fracture surfaces where the failure origin is identified.     

Impact of N on the atomic-scale Sb distribution in quaternary GaAsSbN-capped InAs quantum dots

The use of GaAsSbN capping layers on InAs/GaAs quantum dots (QDs) has recently been proposed for micro- and optoelectronic applications for their ability to independently tailor electron and hole confinement potentials. However, there is a lack of knowledge about the structural and compositional changes associated with the process of simultaneous Sb and N incorporation. In the present work, we have characterized using transmission electron microscopy techniques the effects of adding N in the GaAsSb/InAs/GaAs QD system. Firstly, strain maps of the regions away from the InAs QDs had revealed a huge reduction of the strain fields with the N incorporation but a higher inhomogeneity, which points to a composition modulation enhancement with the presence of Sb-rich and Sb-poor regions in the range of a few nanometers. On the other hand, the average strain in the QDs and surroundings is also similar in both cases. It could be explained by the accumulation of Sb above the QDs, compensating the tensile strain induced by the N incorporation together with an In-Ga intermixing inhibition. Indeed, compositional maps of column resolution from aberration-corrected Z-contrast images confirmed that the addition of N enhances the preferential deposition of Sb above the InAs QD, giving rise to an undulation of the growth front. As an outcome, the strong redshift in the photoluminescence spectrum of the GaAsSbN sample cannot be attributed only to the N-related reduction of the conduction band offset but also to an enhancement of the effect of Sb on the QD band structure.     

A review of energy efficiency label of street lighting systems

There are very few countries that have provisions addressing the energy efficiency of the whole street lighting system, such as Spain or the Netherlands. Nevertheless, there is not an agreement about how energy efficiency must be assessed. The Spanish Government contemplates it in the Royal Decree 1890/2008 with the goal of improving energy savings and efficiency. However, this has not obtained the expected results. Nowadays, energy efficiency of this kind of systems is assessed using a label. In the case of Spain, this label only assesses one magnitude. The contributions of this paper are two evaluation systems (kiviat diagram and pie chart) which assess five magnitudes: lamps, energy efficiency index, light pollution, renewable energy contribution, and harness of the luminous flux using dimming. After that, a survey was done to study several subjects: (1) if citizens are aware about the efficiency of street lighting systems, (2) whether the sample of colors used in the label is adequate, and (3) if our proposed systems could replace the current evaluation system. Finally, the paper finishes with the conclusions of the survey.     

Design,Synthesis and Evaluation of 2,4-Diaminoquinazoline Derivatives as Potential Tubulin Polymerization Inhibitors

Microtubules are highly dynamic polymers composed of α- and β-tubulin proteins that have been shown to be potential therapeutic targets for the development of anticancer drugs. Currently, a wide variety of chemically diverse agents that bind to β-tubulin have been reported. Nocodazole (NZ) and colchicine (COL) are well-known tubulin-depolymerizing agents that have close binding sites in the β-tubulin. In this study, we designed and synthesized a set of nine 2,4-diaminoquinazoline derivatives that could occupy both NZ and COL binding sites. The synthesized compounds were evaluated for their antiproliferative activities against five cancer cell lines (PC-3, HCT-15, MCF-7, MDA-MB-231, and SK-LU-1), a noncancerous one (COS-7), and peripheral blood mononuclear cells (PBMC). The effect of compounds 4 e and 4 i on tubulin organization and polymerization was analyzed on the SK-LU-1 cell line by indirect immunofluorescence, western blotting, and tubulin polymerization assays. Our results demonstrated that both compounds exert their antiproliferative activity by inhibiting tubulin polymerization. Finally, a possible binding pose of 4 i in the NZ/COL binding site was determined by using molecular docking and molecular dynamics (MD) approaches. To our knowledge, this is the first report of non-N-substituted 2,4-diaminoquinazoline derivatives with the ability to inhibit tubulin polymerization.     

Reading in graduate school: A survey of doctoral students in clinical psychology.

To what extent do graduate students in clinical psychology complete assigned readings? A total of 744 graduate students in American Psychological Association-accredited doctoral programs completed an online survey regarding reading in graduate school (67% response rate, of those viewing the survey). The reported amount of assigned reading varied widely, with an average of 330 pages per week. Compliance ratings suggested that about half the assigned reading is completed thoroughly and that thorough reading is more common than skimming or not reading assigned material. Motivating and hindering factors for reading are reported, and implications for faculty are considered. (PsycINFO Database Record (c) 2010 APA, all rights reserved)