The pharmacokinetics of methimazole in pregnant patients after oral administration of carbimazole

1 A high performance liquid chromatographic (HPLC) method was used to study the pharmacokinetics of methimazole after oral administration of carbimazole to women in various stages of pregnancy. 2 In one patient it was possible to conduct the study in the first and third timesters: there was an appreciable increase in the apparent clearance of methimazole. 3 Based on the assumption of complete absorption and hydrolysis of carbimazole to methimazole the mean apparent clearance was found to be significantly higher in pregnant patients receiving 10 mg carbimazole than in non-pregnant patients receiving the same dose.     

Control of larval Aedes aegypti (Diptera: Culicidae) by cyclopoid copepods in peridomestic breeding containers

HIV infection and AIDS create a unique dilemma for women in their potential for vertical transmission of these conditions. Selected feminist perspectives in ontology, epistemology, and axiology are reviewed to illuminate possible social, cultural, and political circumstances of these women. Drawing both on these perspectives and various sources of data about women with HIV/AIDS, some implications for nursing complete this discussion.