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381.
AA Amato K Kagan-Hallet CE Jackson S Lampkin GI Wolfe M Ferrante EH Bigio RJ Barohn 《Canadian Metallurgical Quarterly》1998,51(6):1646-1655
BACKGROUND: Myofibrillar myopathy (MFM) is characterized by nonhyaline lesions (foci of myofibrillar destruction) and hyaline lesions (cytoplasmic inclusions composed of compacted myofibrillar residues) on light and electron microscopy. Immunocytochemistry demonstrates the abnormal expression of desmin and numerous other proteins. The clinical, laboratory, and histologic features of MFM are heterogeneous, making a diagnosis difficult. RESULTS: We diagnosed eight patients with MFM over the preceding 3 years. MFM was inherited in an autosomal dominant pattern in one patient, developed sporadically in five patients, and was induced by an experimental chemotherapy, Elinafide (Knoll, Parsippany, NJ), in two patients. Age at onset ranged from 14 to 64 years. The pattern of weakness was variable but involved proximal and distal muscles. Five patients had evidence of a cardiomyopathy. Electromyography demonstrated muscle membrane instability and small, polyphasic motor unit potentials. Serum creatine kinase levels were normal to moderately elevated (<10x normal). Light and electron microscopy demonstrated the characteristic pattern of nonhyaline and hyaline lesions and the associated abnormalities on immunocytochemistry. CONCLUSIONS: Patients demonstrate a wide spectrum of clinical, laboratory, and histologic abnormalities. Chemotherapy-induced MFM has abnormalities on immunocytochemistry similar to the those of hereditary and sporadic cases. The pathogenesis of MFM is likely heterogeneous. However, MFM is distinctive in that it can preferentially affect distal muscles and has a frequent association with cardiomyopathy. The cardiomyopathy may be amenable to treatment with pacemaker insertion or cardiac transplantation. 相似文献
382.
EH Hani L Suaud P Boutin JC Chèvre E Durand A Philippi F Demenais N Vionnet H Furuta G Velho GI Bell B Laine P Froguel 《Canadian Metallurgical Quarterly》1998,101(3):521-526
OBJECTIVE: Results from several recent studies suggest that the levels of antigenic keratan sulfate (agKS) and hyaluronan (HA) in serum provide useful information about changes taking place in injured or diseased synovial joints. To improve our understanding of the significance of such changes, we investigated the points of entry of these molecules into the blood circulation and their subsequent clearance after experimentally induced injury to rabbit knee joint. METHODS: Chymopapain was injected into knee joints of 8 young adult rabbits to induce aggrecan degradation in articular cartilage within the injected joint. Levels of agKS and HA in serum from various blood vessels were measured before and 5 h after the injury. The statistical significance of injury related changes and differences among the different vessels were evaluated. RESULTS: After the injury, the level of agKS rose most significantly in the popliteal vein draining the injected knee joint and dropped rapidly by the time the blood reached the femoral vein. The level of agKS was similar, although lower, in other blood vessels but, in each case, it was significantly higher than before the injection. The level of HA showed a different pattern of changes after injection. While highest in the popliteal vein draining the injected knee, HA was markedly elevated in the cranial vena cava, close to the entry of lymph into the circulation, and was 50% lower in the hepatic than in the portal vein. CONCLUSION: (1) Measurement of agKS and HA in a blood vessel draining or close to an injured/diseased knee joint may provide more specific information about degradative changes taking place in that joint than measurement of levels of these markers in other blood vessels; (2) some HA molecules but no measurable amounts of agKS enter the blood circulation via the lymphatic system: and (3) HA but not agKS is very rapidly cleared from the blood by the liver. 相似文献
383.
The paper presents 5 cases of histologically verified tuberculous peritonitis followed up by the author in 1994-1996. All patients were admitted to hospital and undergone surgical intervention for emergency indications. The main symptoms were intoxication, abdominal pain and enlargement. Two typical cases are described. Tuberculous peritonitis is recommended to be included into the differential diagnostic list of acute surgical abdominal diseases. 相似文献
384.
HY Dai GI Troseth M Gunleksrud T Bruland LA Solberg H Aarset LI Kristiansen A Dalen 《Canadian Metallurgical Quarterly》1998,72(2):1244-1251
385.
STATEMENT OF PROBLEM: Flexible die materials have been introduced to facilitate the fabrication of indirect provisional or definitive restorations in 1 appointment. PURPOSE: This study compared the surface detail reproduction of 7 potential flexible die materials when used in combination with 7 elastomeric impression materials. METHODS: Surface detail reproduction of 17 impression material/flexible die material systems was compared with a control system containing an elastomeric impression material and a Type IV dental stone. Test dies of each system were prepared in a random order with the American Dental Association apparatus for testing detail reproduction, compatibility, and dimensional stability. RESULTS: One flexible die system had better surface detail reproduction than the control stone die, other systems had similar or worse reproduction. Surface detail reproduction was adversely affected when a separator was required between the impression and flexible die material. CONCLUSIONS: Impregum F die material with Extrude Light impression material produced better surface detail reproduction than the control dies. Impregum F impressions were incompatible with Blu-Mousse, Impregum F, or Imprint die materials. Polyvinyl siloxane impressions were incompatible with polyvinyl siloxane dies unless a separator was used. When a separator was used, the surface detail reproduction was not as good as the control die system or the Extrude Light impression material/Impregum F die material combination. 相似文献
386.
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389.
B Ibarra-Molero GI Makhatadze JM Sanchez-Ruiz 《Canadian Metallurgical Quarterly》1999,1429(2):384-390
Temperature induced unfolding of bovine ubiquitin in solutions with different concentrations of guanidinium hydrochloride (GdmCl) has been measured using differential scanning calorimetry. It has been shown that at high concentrations of GdmCl the ubiquitin molecule can undergo both heat and cold induced denaturation. Analysis of the enthalpy of unfolding of ubiquitin in the presence of GdmCl shows a good agreement with the thermodynamic denaturant binding model. The unfolding Gibbs energy is found to change linearly with guanidine concentration up to zero denaturant concentration. 相似文献
390.
CE Jackson AA Amato WW Bryan GI Wolfe K Sakhaee RJ Barohn 《Canadian Metallurgical Quarterly》1998,50(6):1795-1799
BACKGROUND: An association between primary hyperparathyroidism (PHP) and amyotrophic lateral sclerosis (ALS) has been noted; however, a causal relation between these disorders has not been confirmed. PATIENTS/ METHODS: We report five patients (three men, two women) meeting El Escorial criteria for ALS who also had PHP. In three patients, the diagnosis of PHP was made during the laboratory evaluation for motor neuron disease, and in one patient, the diagnosis of PHP preceded the onset of weakness by 5 months and in another by 2 years. Serum calcium levels in all five patients were elevated, ranging from 11.2 to 12.8 mg/dL (normal, <10.4 mg/dL), as were levels of parathyroid hormone (PTH). RESULTS: All five patients underwent parathyroid adenoma resection with subsequent normalization of serum calcium and PTH levels. Each patient had progressive weakness resulting in death 1 to 3 years following parathyroidectomy. CONCLUSION: Resection of parathyroid adenomas in patients meeting El Escorial criteria for ALS did not alter the course of ALS. PHP and ALS appear to be coexisting but unrelated disorders. 相似文献