Detecting memory impairment with a modified test procedure: Manipulating retention interval with centrally presented event items.

Suggests that detecting memory impairment with the modified test relies on long retention intervals that provide the necessary forgetting of event information for impairing effects of postevent misinformation to occur. 288 Ss were tested in 4 experiments that presented event items centrally, introduced verbal postevent items to a misled condition, and used the modified test, but differed by using either short (15 min) or long (5–7 days) retention intervals. As evidenced by poorer misled than control test performances, memory impairment only occurred with long retention intervals. Retrieval- and storage-based versions of memory-impairment hypotheses are assessed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Lateral-mode analysis of narrow-stripe semiconductor lasers with acylindrically concave end facet

A beam-propagation method is used to investigate numerically the lateral-mode characteristics of GaAlAs semiconductor lasers having a cylindrically concave facet at one end. Various degrees of index guiding have been considered. Simulations were made for both below- and above-threshold regimes. As expected, the numerical results show that the optical beam divergence parallel to the junction plane can be significantly reduced. In addition, this far-field narrowing is accompanied by lower threshold currents. However, for values of the radius of curvature of the concave facet lying in some specific ranges, the losses of the fundamental lateral mode are higher than that calculated for conventional lasers, and the corresponding eigenvalue shows nonmonotonic variations as the injection current is increased. This phenomenon is due to an enhancement of the index antiguiding over the gain-guiding mechanism     

Genetics of programmed cell death in C. elegans: past, present and future

Genetic studies of the nematode Caenorhabditis elegans have defined a variety of single-gene mutations that have specific effects on programmed cell death. Analyses of the genes defined by these mutations have revealed that cell death is an active process that requires gene function in cells that die. Specific genes are required not only to cause cell death but also to protect cells from dying. Gene interaction studies have defined a genetic pathway for the execution phase of programmed cell death in C. elegans. Molecular and biochemical findings are consistent with the pathway proposed from these genetic studies and have also revealed that the protein products of certain cell-death genes interact directly. This pathway appears to be conserved among organisms as diverse as nematodes and humans. Important questions remain to be answered about programmed cell death in C. elegans. For example, how does a cell decide to die? How is cell death initiated? What are the mechanisms of action of the cell-death protector and killer genes? What genes lie downstream of the cell-death execution pathway? The conservation of the central cell-death pathway suggests that additional genetic analyses of programmed cell death in C. elegans will help answer these questions, not only for this nematode but also for other organisms, including ourselves.     

Using drug chronotherapy to wean patients from mechanical ventilation

Discontinuation of positive pressure mechanical ventilation results in decreased intrathoracic pressure. Although there has been extensive research into factors associated with weaning adults from mechanical ventilatory support, little attention has been paid to the role of left ventricular performance. Research also has not focused on interventions that might optimize ventricular performance. The purpose of this article is to explore the potential effect of cardiac dysfunction in weaning and the role of drug chronotherapy as a strategy to modify patients' responses to weaning from mechanical ventilatory support. Biophysical principles involved are reviewed, and the development of a chronotherapeutic intervention is described. Two case examples illustrate the use of drug chronotherapy during the weaning process.     

Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe

Sinus pericranii is an anomalous extracranial vascular malformation that is in continuity with the intracranial dural venous sinuses. Five case reports, three congenital and two traumatic, are described. Clinical management, including evaluation, diagnosis, and treatment, is discussed. Awareness of this entity by plastic surgeons will allow for earlier diagnosis and appropriate surgical management, resulting in decreased risk of complications.