A time optimal wavelength rerouting algorithm for dynamic trafficin WDM networks

In this paper, we consider wavelength rerouting in wavelength routed wavelength division multiplexed (WDM) networks with circuit switching, wherein lightpaths between source-destination pairs are dynamically established and released in response to a random pattern of arriving connection requests and connection holding times. The wavelength continuity constraint imposed by WDM networks leads to poor blocking performance. Wavelength rerouting is a viable and cost effective mechanism that ran improve the blocking performance by rearranging certain existing lightpaths to accommodate a new request. Recently, a rerouting scheme called “parallel move-to-vacant wavelength retuning (MTV-WR)” with many attractive features such as shorter disruption period and simple switching control, and a polynomial time rerouting algorithm, for this scheme, to minimize the weighted number of rerouted lightpaths have been proposed. This paper presents a time optimal rerouting algorithm for wavelength-routed WDM networks with parallel MTV-WR rerouting scheme. The algorithm requires only O(N²W) time units to minimize the weighted number of existing lightpaths to be rerouted, where N is the number of nodes in the network and W is the number of wavelength channels available on a fiber link. Our algorithm is an improvement over the earlier algorithm proposed in that it requires O(N³W+N²W²) time units, which is not time optimal. The simulation results show that our algorithm improves the blocking performance considerably and only very few lightpaths are required to be rerouted per rerouting. It is also established through simulation that our algorithm is faster than the earlier rerouting algorithm by measuring the time required for processing connection requests for different networks     

Parallel feed travelling wave distributed pin photodetectors withintegrated MMI couplers

The fabrication and performance of a parallel feed travelling wave photodetector with pin diodes operating at 1550 nm is presented. A parallel optical feed using an integrated multimode interference (MMI) power splitter helps increase the maximum linear photocurrent through a more uniform distribution of photocurrent. The maximum DC linear current measured is 52.2 mA. Maximum linear RF power at 10 GHz was 9 dBm     

Intelligent Biohybrid Materials for Therapeutic and Imaging Agent Delivery

Many molecular imaging techniques rely on tracer methods to visualize specific physiological processes in cells, animals, and humans. A new family of "smart" delivery systems for biomolecules has opened new opportunities for the molecular imaging field. One class of polymeric carriers reversibly become membrane destabilizing in response to sharp pH changes and were designed for delivering proteins and nucleic acids to intracellular compartments. These carriers could enable the use of imaging agents and intracellular reporters whose site of action made them previously inaccessible. A second class of stimuli-responsive polymer-biomolecule conjugates can be reversibly formed into particles of closely defined sizes. The ability to control when and where the protein or DNA species is in the free versus particle form may allow imaging applications that exploit their differential size and diffusion properties.     

Design and Dimensioning of a WDM Mesh Network to Groom Dynamically Varying Traffic

In this paper, we address the traffic grooming problem in WDM mesh networks when the offered traffic is characterized by a set of traffic matrices—a variant of dynamically changing traffic. We justify the need to address this problem in mesh networks and also argue for the validity of our approach to solve this problem. Our primary objective is to design the network in terms of the number of wavelengths and transceivers required to support any offered traffic matrix. We provide a simple and generic framework to minimize the number of transceivers needed in the network. Simulation results have been presented in contrast with a possible approach, to enable comparison with our solution strategy. An ILP formulation of our approach is also presented.     

Targeting Efficiency and Biodistribution of Zoledronate Conjugated Docetaxel Loaded Pegylated PBCA Nanoparticles for Bone Metastasis

In an attempt to improve tumor localization of docetaxel (DTX)‐loaded nanoparticles (NPs), zoledronic acid (ZOL) is used as a ligand to target bone metastasis. DTX‐loaded ZOL‐conjugated polyethylene glycol (PEG)ylated polybutyl cyanoacrylate (PBCA) NPs are prepared using an anionic polymerization technique. PBCA‐PEG‐ZOL NPs are subjected to cytotoxic assay in both BO2 and MCF‐7 cell lines. Cell cycle arrest and apoptosis induced by the PBCA‐PEG‐ZOL NPs are studied. Quantitative cellular uptake, NP uptake route characterization, confocal microscopy and IPP/ApppI levels are performed. PBCA‐PEG‐ZOL NPs show an enhanced cytotoxic effect in both BO2 as well as MCF‐7 cell lines due to higher uptake following ZOL‐mediated endocytosis. The molecular basis of apoptosis reveals the involvement of a cytoplasmic protein in activating the programmed cell death pathway. Route characterization studies reveal that PBCA‐PEG‐ZOL NPs uptake is not completely blocked even by using both inhibitors (genistein and phenyl arsinoxide) simultaneously, conferring that uptake is not entirely based upon clathrin or caveolae. PBCA‐PEG‐ZOL NPs showed 7 and 5.3 times increase in IPP and ApppI production, in comparison to ZOL treatment, and 138 times higher than the control group in MCF‐7 cell line. In BO2 cell line, after treatment with NPs, IPP was 5.35 times higher than ZOL solution. No ApppI in BO2 cell line after treatment with NPs and ZOL solution was found. NP distribution in tumor infected bone is also significantly high in comparison to the normal bone at any time point. It is concluded that ZOL‐conjugated NPs provide an efficient and targeted delivery of DTX, with synergistic effects. Thus, these NPs present a promising treatment in the near future, by actively targeting metastatic tumor.     

Strategic warranty management: a life-cycle approach

The role of warranty has become increasingly important, both as a promotional (particularly where competing products are nearly indistinguishable) and as a protectional device (for complex and expensive products where customers need some assurance). Offering warranty implies additional cost to the manufacturer over the period from product launch to obsolescence. This cost is influenced by technical decisions made prior to the launch. This paper develops a strategic approach to warranty management where warranty-related decisions are made in a framework encompassing the product life cycle and from a business perspective which links technical and commercial issues     

Performance modeling of DTN routing with heterogeneous and selfish nodes

The performance modeling study of Delay-Tolerant Network routing, in general, assumes the nodes to be homogeneous (in terms of features such as the coverage range) and uncompromised (in terms of forwarding messages). However, in realistic settings this may not be the case. The routing performance modeling of such realistic scenarios that involve multifariously-featured and egotistic nodes would be interesting and insightful. To this end, in this paper, we analytically model the routing behavior of such nodes using Ordinary Differential Equations for two different routing protocols namely, Epidemic Routing and Two-Hop Routing. Furthermore, we also study the degradation in the routing performance caused by an increase in the fraction of selfish nodes present in the heterogeneous node population. The proposed analytical model is validated via extensive simulations.     

Provable secure lightweight hyper elliptic curve‐based communication system for wireless sensor networks

It is widely believed that hyper elliptic curve cryptosystems (HECCs) are not attractive for wireless sensor network because of their complexity compared with systems based on lower genera, especially elliptic curves. Our contribution shows that for low cost security applications HECs cryptosystems can outperform elliptic curve cryptosystems. The aim of this paper is to propose a discrete logarithm problem‐based lightweight secure communication system using HEC. We propose this for different genus curves over varied prime fields performing a full scale study of their adaptability to various types of constrained networks. Also, we propose to evaluate the performance of the protocol for computational times with respect to different genus for main operations like Jacobian, Divisor identifications, key generation, signature generation/verification, message encryption, and decryption by changing the size of the field. A formal security model was established based on the hardness of HEC‐Decision Diffie‐Hellman (HEC‐DDH). Finally, a comparative analysis with ECC‐based cryptosystems was made, and satisfactory results were obtained.     

Modeling and Analysis of On-Chip Single and H-tree Distributed RLC Interconnects

This paper presents novel methods for modeling and analysis of on-chip Single and H-tree distributed resistance inductance capacitance interconnects. The matrix pade-type approximation and scaling and squaring methods are employed for the numerical estimation of delay in single interconnect, and H-tree interconnects. The proposed models, which are based on these methods, provide rational function approximation for obtaining a passive interconnect model. Multiple single input single output model approximated transfer functions are developed for H-tree interconnects structure. With the equivalent reduced order lossy interconnect transfer functions, finite ramp responses are obtained, and line delay is estimated for various line lengths, input ramp rise times, source resistances, parasitic capacitances and load capacitances. In order to demonstrate the accuracy of proposed models, the estimated 50 % delay values are compared with the standard HSPICE W-element model and are found to be in good agreement. The proposed models worst case 50 % delay errors of single interconnect are 0.27 and 0.24 % respectively, while the worst case 50 % delay errors of H-tree structure are 5.73 and 3.94 % respectively.