Human immunodeficiency virus infection, Part II

The acceptance of highly active antiretroviral therapy (HAART) among patients and health care providers has had a dramatic impact on the epidemiology and clinical characteristics of many opportunistic infections associated with human immunodeficiency virus (HIV). Previously intractable opportunistic infections and syndromes are now far less common. In addition, effective antibiotic prophylactic therapies have had a profound impact on the risk of patients developing particular infections and on the incidence of these infections overall. Most notable among these are Pneumocystis carinii, disseminated Mycobacterium avium complex, tuberculosis, and toxoplasmosis. Nevertheless, infections continue to cause significant morbidity and mortality among patients who are infected with HIV. The role of HAART in many clinical situations is unquestioned. Compelling data from clinical trials support the use of these therapies during pregnancy to prevent perinatal transmission of HIV. HAART is also recommended for health care workers who have had a "significant" exposure to the blood of an HIV-infected patient. Both of these situations are discussed in detail in this article. In addition, although more controversial, increasing evidence supports the use of HAART during the acute HIV seroconversion syndrome. An "immune reconstitution syndrome" has been newly described for patients in the early phases of treatment with HAART who develop tuberculosis, M avium complex, and cytomegalovirus disease. Accumulating data support the use of hydroxyurea, an agent with a long history in the field of myeloproliferative disorders, for the treatment of HIV. Newer agents, particularly abacavir and adefovir dipivoxil, are available through expanded access protocols, and their roles are being defined and clarified.     

Is computational complexity a barrier to manipulation?

When agents are acting together, they may need a simple mechanism to decide on joint actions. One possibility is to have the agents express their preferences in the form of a ballot and use a voting rule to decide the winning action(s). Unfortunately, agents may try to manipulate such an election by mis-reporting their preferences. Fortunately, it has been shown that it is NP-hard to compute how to manipulate a number of different voting rules. However, NP-hardness only bounds the worst-case complexity. In this survey article, we summarize the evidence for and against computational complexity being a barrier to manipulation. We look both at techniques identified to increase complexity (for example, hybridizing together two or more voting rules), as well as other features that may change the computational complexity of computing a manipulation (for example, if votes are restricted to be single peaked then some of the complexity barriers fall away). We discuss recent theoretical results that consider the average case, as well as simple greedy and approximate methods. We also describe how computational ??phase transitions??, which have been fruitful in identifying hard instances of propositional satisfiability and other NP-hard problems, have provided insight into the hardness of manipulating voting rules in practice. Finally, we consider manipulation of other related problems like stable marriage and tournament problems.     

Accelerating geoscience and engineering system simulations on graphics hardware

Many complex natural systems studied in the geosciences are characterized by simple local-scale interactions that result in complex emergent behavior. Simulations of these systems, often implemented in parallel using standard central processing unit (CPU) clusters, may be better suited to parallel processing environments with large numbers of simple processors. Such an environment is found in graphics processing units (GPUs) on graphics cards.This paper discusses GPU implementations of three example applications from computational fluid dynamics, seismic wave propagation, and rock magnetism. These candidate applications involve important numerical modeling techniques, widely employed in physical system simulations, that are themselves examples of distinct computing classes identified as fundamental to scientific and engineering computing. The presented numerical methods (and respective computing classes they belong to) are: (1) a lattice-Boltzmann code for geofluid dynamics (structured grid class); (2) a spectral-finite-element code for seismic wave propagation simulations (sparse linear algebra class); and (3) a least-squares minimization code for interpreting magnetic force microscopy data (dense linear algebra class). Significant performance increases (between 10× and 30× in most cases) are seen in all three applications, demonstrating the power of GPU implementations for these types of simulations and, more generally, their associated computing classes.     

Water,image, gesture and sound: composing and performing an interactive audiovisual work

Performing and composing for interactive audiovisual system presents many challenges to the performer. Working with visual, sonic and gestural components requires new skills and new ways of thinking about performance. However, there are few studies that focus on performer experience with interactive systems. We present the work Blue Space for oboe and interactive audiovisual system, highlighting the evolving process of the collaborative development of the work. We consider how musical and technical demands interact in this process, and outline the challenges of performing with interactive systems. Using the development of Blue Space as a self-reflective case study, we examine the role of gestures in interactive audiovisual works and identify new modes of performance.     

Schools as healthful environments: prerequisite to comprehensive school health?

The development of healthy schools to support and nature the well-being of students, teachers, and staff is proposed as a first step toward the goal of comprehensive health education. A focus on healthy schools incorporates elements of an expanded concept of comprehensive health education that demands careful consideration of the physical, psychological, and social environment of the nation's schools--worksite to 51 million (students, teachers, and staff). The active participation of all stakeholders in environmental assessments, health and safety audits, and restructuring of schools is an essential part of the school reform movement. A healthy worksite concept supports the transformation of the school environment to increase "productivity" by enhancing the ability of teachers, staff, and students to function well.     

Graduate school origins of Journal of Counseling Psychology authors: Volumes 15-28.

Examined the graduate school origins of authors of Journal of Counseling Psychology (JCP) articles in Volumes 15–28 to extend a previous analysis of Volumes 1–24 by the 3rd author et al (1969). Comparisons of the 2 14-yr periods reveal that some universities retained the same or similar ranks across both periods, some declined in importance as sources of authors, and others emerged as major sources of JCP authors. (6 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Examining infants' preferences for tempo in lullabies and playsongs.

Caregivers around the world sing to their infants. Infants not only prefer to listen to infant-directed singing over adult-directed singing, but infant-directed singing also serves a function, communicating affective information to preverbal infants to aid in adjusting arousal levels. Pitch variation has previously been identified as one performance feature that may help to convey the message. Earlier research has indicated that infants' pitch preferences are context dependent, suggesting that infants are tuned in to the communicative intent of infant-directed singing. However, there are several other performance-based features present in infant-directed singing that may also contribute to the affective message. The current study examined the role of context on infants' tempo preferences in sung playsongs and lullabies. Using a head-turn preference procedure, we measured 24 preverbal infants' natural preferences for foreign language playsongs and lullabies as a function of tempo. Infants showed a preference for fast over slow tempo playsongs, but no such context dependent preference was found within lullabies. Results partially support the role of tempo as a communicative feature of infant directed singing. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

超越“纳米级”设计时代

毫无疑问,我们正在跨入“纳米级”设计时代（处于1000nm到1nm级别的设计）的后期阶段。在未来18个月内,我们将开始部署32nm设计流程;而且,从32nm跨越到22nm所存在的障碍已经被攻克。我们将会在65nm和45/40nm之间采用有效率的、以价值为基础的设计流程。我们将乐于获得多CPU芯片和虚拟软件支持带来的优越性,凭借着新型设计平台的威力,迎来产品和应用新一轮的蓬勃发展。新型设计平台使设计公司可以充分发挥各种成本／功能／价值工艺节点之所长,满足当前市场上的定制需求。