Musculoskeletal status and disability of MMPI profile subgroups among patients with low back pain.

Studied Minnesota Multiphasic Personality Inventory (MMPI) profiles of 362 patients with acute and chronic low back pain (LBP) for replicable homogeneous subgroups using 3 cluster-analysis procedures. Two normal and 3 clinically elevated profile subgroups were identified. The 2 normal subgroups were characterized by relatively normal musculoskeletal condition and were least disabled but differed from each other in duration of pain, presence of physical abnormalities, and daily functioning. The most pathologic profile subgroup consisted largely of acute-pain patients whose musculoskeletal condition and daily functioning were similar to those of the normal subgroups. Patients in the 3 abnormal MMPI subgroups were exposed to more LBP physical-risk factors in the workplace. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Design Rules for Reliability & Maintainability in Electronics

The automation of the design of electronics has advanced greatly since the middle 1970s. The state of this development is such that additional considerations are now being incorporated into the automation process. One of the essential elements of a successful electronics design is reaching the reliability and maintainability (R&M) potential that should be achieved in any design effort. The automation of portions of the design process to address R&M must be based upon design rules that are basic to producing a reliable and maintainable system. This paper discusses a framework for considering these R&M design rules and points the developers of computer-aided engineering systems in the direction that is necessary if electronics designs are to realize their potential.     

Toxicity of Detroit River Sediment-Bound Contaminants to Ultraplankton

Four sites in the Detroit River/Lake Erie western basin were evaluated for their toxicity. The evaluation was based on 1) bulk chemical characterization of the sediments, 2) chemical composition of the sediment elutriates, and 3) toxicity of the elutriates to ultraplankton and microplankton/net plankton. A sequence of decreasing contamination was determined from the chemical composition of the elutriates based on the elutriation release of metals such as Zn, Mn, Cd, Ni, and Co. Bioassessment of elutriate toxicity was determined by carbon-14 Algal Fractionation Bioassays (AFB's) which were conducted with various dilutions of standard and Chelex-100 treated elutriates. Site A (near Windsor, Ontario) and Site D (western Lake Erie) were found to be toxic to ultraplankton. The observed toxicity was attributed to the bioavailability and synergistic impact of elutriated metals on ultraplankton production. A direct relationship between the water soluble metal fraction and toxicity was observed. These results confirmed that sediment toxicity should not be evaluated solely on bulk chemical composition of the sediments. The AFB's have been proven useful in the bioassessment of sediments due to their rapidity/sensitivity and hence could be routinely used for the screening and early detection of contaminants affecting fast growing organisms which form the basis of the aquatic food chain.     

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Ohne Zusammenfassung     

Thrombopoietic factors potentially useful in the treatment of acute leukemia

Thrombocytopenia is a major cause of morbidity following intensive chemotherapy for acute leukemia. Over recent years, there has been an increasing use of platelet transfusions which, although generally efficacious to prevent severe hemorrhage, have associated risks of transmitting blood-borne disease and of alloimmunization. Therefore, there is a clinical requirement for a drug that will reliably alleviate the thrombocytopenia associated with leukemia therapy. The c-mpl ligand thrombopoietin is the most interesting factor for the treatment of thrombocytopenia because of its lineage specificity. Phase I and II studies confirm its biological efficacy to induce rise in platelet count in patients with solid tumors and acute leukemia. Several other pleiotropic hematopoietic growth factors are also currently in clinical trials. These include interleukin-6, interleukin-3, interleukin-11, PIXY321 and stem cell factor. The effects of these cytokines appear to be modest at most and, with the exception of interleukin-11, their side effects are likely to limit their clinical application. Combinations of factors may prove more efficacious approaches to enhance platelet recovery.     

EIR1, a root-specific protein involved in auxin transport, is required for gravitropism in Arabidopsis thaliana

The EIR1 gene of Arabidopsis is a member of a family of plant genes with similarities to bacterial membrane transporters. This gene is expressed only in the root, which is consistent with the phenotypes of the eir1 mutants-the roots are agravitropic and have a reduced sensitivity to ethylene. The roots of eir1 mutants are also insensitive to the excess auxin produced by alf1-1 and fail to induce an auxin-inducible gene in the expansion zone. Although they fail to respond to internally generated auxin, they respond normally to externally applied auxin. Expression of the EIR1 gene in Saccharomyces cerevisiae confers resistance to fluorinated indolic compounds. Taken together, these data suggest that the EIR1 protein has a root-specific role in the transport of auxin.     

Mathematical and Scientific Foundations for an Integrative Engineering Curriculum

All fields of engineering, whether chemical, civil, electrical, materials, mechanical, etc., encompass a common body of essential mathematics and science. In the freshman year of Drexels E⁴ program, this common mathematical and scientific foundation is cultivated in the Mathematical and Scientific Foundations of Engineering I, II and III (MSFE I, MSFE II, MSFE III). In an integrated fashion, MSFE I presents the essential calculus, physics and engineering mechanics vital to the freshman engineering student. In the first two quarters, MSFE II presents chemistry with clearly defined engineering applications and significance: in the third quarter, MSFE II presents living systems with the same thrust. Also in the third quarter, MSFE III presents basic circuits and circuit elements, and a brief introduction to electromagnetic theory.