DRYING OF OPTICALLY SEMITRANSPARENT MATERIALS BY COMBINED RADIATIVE-CONVECTIVE HEATING

The objective of this work has been to basically elucidate the drying characteristics of an optically semitransparent material by combined radiative and convective heating. The experiments were conducted for a graphite suspension, a slurry of surplus activated sludge and a wet silica sand. The time-change of the drying rate as well as of the surface temperature of the brimfully wet material layer were measured under the step heating conditions using an infrared lamp bundle and a blast of hot air heated by an electric heater.

The experimental data obtained show satisfactory agreement with the calculated results from unsteady heat and mass transfer equations derived on the basis of a semitransparent drying model during the preheating and the constant drying rate periods.     

Soft Margins for AdaBoost

Recently ensemble methods like ADABOOST have been applied successfully in many problems, while seemingly defying the problems of overfitting.ADABOOST rarely overfits in the low noise regime, however, we show that it clearly does so for higher noise levels. Central to the understanding of this fact is the margin distribution. ADABOOST can be viewed as a constraint gradient descent in an error function with respect to the margin. We find that ADABOOST asymptotically achieves a hard margin distribution, i.e. the algorithm concentrates its resources on a few hard-to-learn patterns that are interestingly very similar to Support Vectors. A hard margin is clearly a sub-optimal strategy in the noisy case, and regularization, in our case a mistrust in the data, must be introduced in the algorithm to alleviate the distortions that single difficult patterns (e.g. outliers) can cause to the margin distribution. We propose several regularization methods and generalizations of the original ADABOOST algorithm to achieve a soft margin. In particular we suggest (1) regularized ADABOOST_REG where the gradient decent is done directly with respect to the soft margin and (2) regularized linear and quadratic programming (LP/QP-) ADABOOST, where the soft margin is attained by introducing slack variables.Extensive simulations demonstrate that the proposed regularized ADABOOST-type algorithms are useful and yield competitive results for noisy data.     

Gustatory disturbance due to cerebrovascular disorder

In the presence of denaturant and thiol catalyst, a disulfide-containing protein denatures and converts to a mixture of scrambled isomers, which can be purified and structurally characterized. Scrambled isomers adopt a different conformation and a varied extent of unfolding. Their relative concentration (composition) signals the state of unfolding of the denatured protein and is determined by the denaturing condition. In this report, tick anticoagulant peptide (TAP) (60 amino acids and 3 disulfides) has been denatured in the presence of urea, guanidine hydrochloride, guanidine thiocyanate, organic solvents, and at elevated temperature. The recoveries of scrambled TAP were analyzed. The results demonstrate that each denaturing condition generates a unique structure (composition of scrambled species) of denatured TAP. Among various species of scrambled TAP, the beads-form species contains the smallest disulfide loop and appears to represent the most extensively unfolded state. The yield of the beads-form species as a fraction of the total denatured TAP is invariably determined by the strength of the denaturing condition.     

Effect of Alkali Ions on the Crystallization of 3BaO·5SiO2 Glass

In this study we have investigated the effects of alkali additions on the spherulitic crystallization process in 3BaO·5SiO₂ glass. Both Li⁺ and Na⁺ increased the growth rate of the spherulites and reduced the crystallization temperature from that in the base glass. Li⁺ and Na⁺ also reduced the temperature at which the microstructural transformation from spherulites to laths took place. Dielectric loss measurements suggest that the effect of the alkali additions on crystallization temperature is due to their concentration in grain boundaries, thereby lowering the viscosity of the remaining glass, and increasing mobility rates.     

Relation of endothelium, thrombogenesis, and hemorheology in systemic hypertension to ethnicity and left ventricular hypertrophy

Although the arterial tree is exposed to increased pressure in hypertensive patients, paradoxically, the complications of hypertension (heart attacks, stroke) are mainly thrombotic rather than hemorrhagic. Patients with left ventricular (LV) hypertrophy are at high risk of the complications of hypertension. We performed a cross-sectional study of 178 patients attending a hypertension clinic in a city center teaching hospital, and measured plasma levels of the soluble adhesion molecule P-selectin (associated with platelet activity/function and atherosclerosis), the von Willebrand factor (vWf; a marker of endothelial dysfunction), fibrin D-dimer (an index of thrombogenesis), plasminogen activator inhibitor (PAI, an index of fibrinolysis), lipoprotein(a) (Lp(a), associated with thrombogenesis and atherogenesis) and hemorheological indexes (fibrinogen, hematocrit, plasma viscosity, hemoglobin) in patients with essential hypertension, in whom the LV mass and LV mass index were determined using echocardiography. The 178 patients (86 men, mean age 54 +/- 15 years) were compared with 47 normotensive healthy controls (aged 56 +/- 20 years). Hypertensive patients had higher P-selectin, PAI, vWf, fibrin D-dimer, Lp(a), plasma fibrinogen, and plasma viscosity when compared with controls. Black hypertensive patients had higher Lp(a) levels and LV septal and posterior wall thickness on echocardiography, but lower plasma PAI levels. Patients with LV hypertrophy (defined as a LV mass index > 134 g/m2 in men or > 110 g/m2 in women) had higher plasma fibrinogen compared with those without LV hypertrophy. Systolic blood pressures were significantly correlated to age, plasma viscosity, plasma fibrinogen, and vWf. Diastolic blood pressures were significantly correlated with age and plasma fibrinogen. Fibrinogen levels were correlated with LV mass, LV mass index, left atrial size, plasma viscosity, and vWf. Fibrin D-dimer levels were significantly correlated with vWf and fibrinogen levels. Thus, hypertensive patients have high plasma fibrinogen levels, thrombogenesis, and impaired fibrinolysis (as indicated by high D-dimer and PAI levels, respectively), platelet activation (raised soluble P-selectin), and endothelial dysfunction (high vWF). The high plasma fibrinogen levels were related to blood pressures, LV mass index (and LV hypertrophy), and left atrial size. These abnormalities in hemorheologic factors and markers of thrombogenesis and endothelial function may act synergistically to increase the risk of thrombogenesis and atherosclerosis in hypertensive patients.     

Preparation of smooth and dense composite films consisting of MEHPPV and neat C60 by means of electrophoretic deposition

A procedure to prepare flat and dense composite films of a conjugated polymer poly[2-methoxy-5-(2′-ethylhexyloxy)-1,4-phenylene vinylene] (MEHPPV) and various amounts of neat C₆₀ by means of electrophoretic deposition from dilute suspensions is reported. It has been observed that deposition from suspensions containing both components results in pinhole-free films, which are applicable to photovoltaic devices, while inhomogeneous films are formed from the suspensions containing only one of the components. The applicability of electrophoretic deposition to obtain polymer-C₆₀ composite films showing photovoltaic effects has been successfully demonstrated.     

Electrophoretic deposition of conjugated polymer: Deposition from dilute solution and PEDOT coating effect

It has been shown that the films of a soluble conjugated polymer poly[(9,9-dioctyl-2,7-divinylene fluorenylene)-alt-{2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene}] for electronic devices can be prepared by the electrophoretic deposition with polymer suspensions derived from dilute polymer solutions which are so dilute that the conventional spin-coating technique is not applicable. For example, a 100 nm-thick film can be prepared on an indium-tin-oxide (ITO) electrode from a suspension from solution containing 0.1 g/l of the polymer. The thickness of the polymer film deposited is found to be almost proportional to the concentration of the polymer, and the linearity down to 5.0 × 10^?3 g/l is confirmed. On the other hand, it has been found that coating the ITO electrode with poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) salt results in low and nonlinear deposition rate.     

Aberrant methylation of p16INK4a and deletion of p15INK4b are frequent events in human esophageal cancer in Linxian, China

Esophageal transit scintigraphy seems to be a valid methodology to assess impaired esophageal motility in early stages of disease. The purpose of this study was to discriminate patients with primary Raynaud's phenomenon (RP) and patients with systemic sclerosis (SSc) from healthy subjects by esophageal scintigraphy with a semisolid meal. METHODS: We studied 32 patients with primary RP, 18 with SSc and 13 healthy subjects. Dysphagia, acid regurgitation and heartburn were scored. After an overnight fast, all subjects underwent esophageal scintigraphy, using a semisolid orally ingested bolus (10 mL apple puree) labeled with 99mTc-sulfur colloid. Esophageal transit and emptying time and integral value were evaluated with the subjects in the upright (sitting) and supine positions. Transit time was defined as the time from the entry of 50% of radioactivity into the upper esophagus until the clearance of 50% of the bolus from the whole esophagus. Emptying time was defined as the time from the entry of 50% of radioactivity into the upper esophagus, until the clearance of 100% of the bolus from the whole esophagus. Integral value was defined as the total counts under the time-activity curve normalized to the maximum. RESULTS: Esophageal transit and emptying time and integral value, evaluated in both positions, were significantly higher in patients with SSc than in healthy subjects and than in patients with RP. Moreover, patients with RP had all three parameters, assessed in supine position, significantly longer compared to healthy subjects. Clinical scores regarding dysphagia, acid regurgitation and heartburn were not significantly different between patients with RP and SSc. CONCLUSION: Esophageal transit and emptying time and integral value appear to be able to discriminate patients with primary RP from patients with SSc and patients with RP from healthy subjects, suggesting an early mild esophageal dysfunction in RP.