A statistical engineering strategy for mixture problems with process variables

Experimenting with both mixture components and process variables, especially when there is likely to be interaction between these two sets of variables, is discussed. We consider both design and analysis questions within the context of addressing an actual mixture/process problem. We focus on a strategy for attacking such problems, as opposed to finding the best possible design or best possible model for a given set of data. In this sense, a statistical engineering framework is used. In particular, when we consider the potential of fitting parsimonious linear additive or nonlinear models as opposed to larger linearized models, we find potential to reduce the size of experimental designs. It is difficult in practice to know what type of model will best fit the resulting data. Therefore, an integrated, sequential design and analysis strategy is recommended. Using two published data sets and one new data set, we find that in some cases nonlinear models, or linear additive models —with no process/mixture interaction terms, enable reduction of experimentation on the order of 50%. In other cases, additive or nonlinear models will not suffice. We therefore provide guidelines as to when such an approach is likely to succeed, and propose an overall strategy for these types of problems.     

From wheat sourdough to gluten‐free sourdough: a non‐conventional process for producing gluten‐free bread

Gluten‐free (GF) sourdough was prepared from wheat sourdough and analysed both in fresh (GFS) and dried forms (DGFS). The gluten content in each GF sourdough sample was <20 mg kg^?1. The dough leavening capacity and the properties of the bread samples were investigated and compared to those of bread prepared using bakery yeast (Saccharomyces cerevisiae). Two commercial rice‐based mixtures (different for the presence/absence of buckwheat flour) were used to prepare bread samples. In GFS, lactic acid bacteria (LAB) and yeasts were found in amounts corresponding to 10⁸ and 10⁷ CFU g^?1, respectively, whereas both LAB and yeasts were detected in lower amounts (about 10⁶ CFU g^?1) in DGFS. When used in bread‐making, both GFS types produced significant dough acidification and exhibited good dough development during proofing, resulting in loaves with specific volume values between 3.00 and 4.12 mL g^?1, values similar to those obtained for reference bread (3.05÷4.15 mL g^?1). The use of GFS was effective in lowering the bread staling rate during storage for up to 7 days.     

A Fluid-Dynamic Traffic Model on Road Networks

We consider a mathematical model for fluid-dynamic flows on networks which is based on conservation laws. Road networks are studied as graphs composed by arcs that meet at some nodes, corresponding to junctions, which play a key-role. Indeed interactions occur at junctions and there the problem is underdetermined. The approximation of scalar conservation laws along arcs is carried out by using conservative methods, such as the classical Godunov scheme and the more recent discrete velocities kinetic schemes with the use of suitable boundary conditions at junctions. Riemann problems are solved by means of a simulation algorithm which processes each junction. We present the algorithm and its application to some simple test cases and to portions of urban network.     

Nutritional quality and safety of European perch (Perca fluviatilis) from three lakes of Central Italy

European perch (Perca fluviatilis) harvested from three lakes of Central Italy were studied in different seasonal periods of a year to evaluate their nutritional quality and some safety aspects related to the pollution of the aquatic environment. The lakes considered, located in the Latium region, differed with respect to their volcanic (Bolsena and Bracciano Lakes) or artificial (Salto Lake) origin. Fillets of fish caught in the three lakes were characterised by good protein (17–19%) and mineral contents and low lipid levels (0.6–1.2%) throughout the year. Total lipids were characterised by low cholesterol levels (41.9–74.7 mg/100 g) and high percentages of total n − 3 polyunsaturated fatty acids (27.7–33.8% of total fatty acids), in particular docosahexaenoic acid (14.2–25.3% of total fatty acids). The qualitative analysis of the stomach content of perch confirmed their predatory feeding behaviour. The chemical and nutritional profiles of perch from the three lakes were comparable except for rubidium and cesium levels, which were higher in the muscle tissues of perch from the volcanic lakes. These minerals may represent elements of traceability of the origin of fish. Low levels of organochlorine pesticides and polychlorinated biphenyls, well below the Italian and European action limits, were detected in the muscle tissue of perch from all three lakes.     

A Mathematical Network Model and a Solution Algorithm for IaaS Cloud Computing

Networks and Spatial Economics - Cloud Computing is a type of Internet-based computing, much used in recent years, that relies on sharing computer processing resources and data to computers and...     

Molecular Modeling Studies on the Human Neuropeptide S Receptor and Its Antagonists

Neuropeptide S (NPS) is a 20‐residue peptide of great interest due to its potential involvement in several biological processes such as arousal, anxiety, and food intake. The NPS receptor belongs to the rhodopsin‐like G‐protein‐coupled receptor superfamily, and several polymorphisms and isoforms of this receptor are associated with asthma, allergies, and bronchial hyper‐responsiveness, in particular the Asn 107 Ile mutation. Limited structural information is available for this peptide–receptor system, particularly regarding the NPS receptor structure, its nonpeptide ligands, and the molecular aspects of agonist and antagonist binding processes. In this work, rhodopsin‐based homology models of the NPS receptor and its Asn 107 Ile variant were built and refined in a membrane bilayer model, and binding modes for nonpeptide antagonists were simulated. This study provides the first structural study of the human NPS receptor, and the results provide a starting point for further characterization of the binding modes of its antagonists, and for the rational design of new NPS receptor ligands.     

On the use of TEM cells for the calibration of power frequency electric field meters

This paper focuses on the performances of TEM cells when used in the calibration of power frequency environmental electric field meters. The spatial non-uniformity of the electric field inside a TEM cell is analyzed through experimental investigations and three-dimensional Boundary Element modeling to evaluate the field experienced by the sensing elements of actual 3D meter probes. The perturbation caused by the probe support is also taken into account. The uncertainty component associated with the spatial non-uniformity in the volume taken up by typical power and low frequency field probes is estimated. The field non-uniformity is also evaluated in relation to the use of TEM cells of reduced size. Finally, the field non-uniformity is exploited to predict the performance of an actual field meter operating in significant field gradients.     

Photopolarimeter based on two gratings recorded in thin organic films

A photopolarimeter based on two different kinds of diffraction gratings (a two-grating photopolarimeter) has been developed for real-time measurements of the four elements of the Stokes vector. The main elements of the device are a pure polarization grating and an ordinary transmission grating, both recorded by means of holographic techniques in thin films of organic materials. The first one consists of a diffraction grating recorded by two interfering opposite circularly polarized beams in a Langmuir-Blodgett film of an azo-compound material. The second component is a grating recorded by two interfering parallel circularly polarized beams in a thin film of a photosensitive polymer. Both gratings offer long time stability and good diffraction efficiency. Four photodiodes collect the first-order diffracted beams from these gratings, the output signals of which are read through an analog-to-digital converter by a PC. The optical alignment of the device is easy and the calibration is realized in a one-step procedure.