The effect of cholesterol supplementation on glutamate-induced hypocholesterolemia in the Mongolian gerbil

The effect of cholesterol supplementation on the hypocholesterolemia induced by glutamic acid feeding has been studied in the Mongolian gerbil. Serum triglycerides and phospholipids and hepatic cholesterol and triglyceride contents have also been studied during the control and glutamate feeding. Cholesterol supplementation (0.05% and 1.0%) did not diminish the hypocholesterolemic response (20–24% decrease in serum cholesterol). The glutamate amino acid formula diet caused no change in serum triglyceride, serum phospholipid, hepatic cholesterol and hepatic triglyceride content when compared to the control formula diet. No lesions of the hypothalamic or paraventricular areas of the brain were noted on histological preparation in adult gerbils given large amounts of glutamic acid orally.     

Parents' job insecurity affects children's academic performance through cognitive difficulties.

The authors developed and tested a model in which children who perceive their parents to be insecure about their jobs are distracted cognitively, which in turn affects their academic performance negatively. Participants were 102 female and 18 male undergraduates (mean age?=?18 years), their fathers (mean age?=?49 years), and their mothers (mean age?=?47 years). Students completed questionnaires measuring perceived parental job insecurity, identification with parents, and cognitive difficulties; 3 months later, they also reported their midyear grades. Fathers and mothers each completed questionnaires assessing their job insecurity. Support for the model was obtained using LISREL 8, and as predicted, children's identification with their mothers and fathers moderated the relationship between their perceptions of their mothers' and fathers' job insecurity and their own cognitive difficulties. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The role of religion in medical rehabilitation outcomes: A longitudinal study.

ABSTRACT. Objective: To investigate the protective and consolation models of the relationship between religion and health outcomes in medical rehabilitation patients. Design: Longitudinal study, data collected at admission, discharge, and 4 months postadmission. Measures: Religion measures were public and private religiosity, acceptance, positive and negative religious coping, and spiritual injury. Outcomes were self-report of activities of daily living (ADL), mobility, general health, depression, and life satisfaction. Participants: 96 medical rehabilitation inpatients; diagnoses included joint replacement, amputation, stroke, and other conditions. Results: The protective model of the relationship between religion and health was not supported; only limited support was found for the consolation model. In regression analyses, negative religious coping accounted for significant variance in follow-up ADL (5%) over and above that accounted for by admission ADL, depression, social support, and demographic variables. Subsequent item analysis indicated that anger with God explained more variance (9%) than the full negative religious coping scale. Conclusions: Religion did not promote better recovery or adjustment… (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Hematological and lipid changes in newborn piglets fed milk-replacer diets containing erucic acid

Canola oil is not presently permitted in infant formulations in the United States because of lack of information concenring the effects of feeding canola oil to the newborn. We have previously reported a transient decrease in platelet counts and an increase in platelet size in newborn piglets fed canola oil for 4 wk, and have confirmed this in the present study. In canola oil-fed piglets, changes in platelet size and number were overcome by adding either long-chain saturated fatty acids from cocoa butter (16:0 and 18:0), or shorter-chain saturates from coconut oil (12:0 and 14:0). Feeding a high erucic acid rapeseed (HEAR) oil, with 20% 22:1n−9, led to an even greater platelet reduction and increased platelet size throughout the 4-wk trial. Bleeding times were longer in piglets fed canola oil or HEAR oil compared to sow-reared and soybean oil-fed piglets. There were no other diet-related changes. Diet-induced platelet changes were not related to platelet lipid class composition, but there were fatty acid changes. The incorporation of 22:1n−9 into platelet phospholipids of piglets fed canola oil was low (0.2–1.2%), and even for the HEAR oil group ranged from only 0.2% in phosphatidylinositol to 2.4% in phosphatidylserine. A much greater change was observed in the concentration of 24:1n−9 and in the 24:1n−9/24:0 ratio in platelet sphingomyelin (SM). The 24:1n−9 increased to 49% in the HEAR oil group compared to about 12% in animals fed the control diets (sow-reared piglets and soybean oil-fed group), while the 24:1n−9/24:0 ratio increased from about 1 to 12. Even feeding canola oil, prepared to contain 2% 22:1n−9, led to a marked increase in 24:1n−9 to 29% and had a 24:1n−9/24:0 ratio of 5. The canola oil/cocoa butter group, which also contained 2% 22:1n−9, showed a lower level of 24:1n−9 (20%) and the 24:1n−9/24:0 ratio (3) compared to the canola oil group. The results suggest that the diet-related platelet changes in newborn piglets may be related to an increase in 24:1n−9 in platelet SM, resulting from chain elongation of 22:1n−9. The inclusion of canola oil as the sole source of fat in the milk-replacer diets of newborn piglets resulted in significant platelet and lipid changes.     

Oil supply limits and the continuing financial crisis

Since 2005, (1) world oil supply has not increased, and (2) the world has undergone its most severe economic crisis since the Depression. In this paper, logical arguments and direct evidence are presented suggesting that a reduction in oil supply can be expected to reduce the ability of economies to use debt for leverage. The expected impact of reduced oil supply combined with this reduced leverage is similar to the actual impact of the 2008–2009 recession in OECD countries. If world oil supply should continue to remain generally flat, there appears to be a significant possibility that oil consumption in OECD countries will continue to decline, as emerging markets consume a greater share of the total oil that is available. If this should happen, based on these findings we can expect a continuing financial crisis similar to the 2008–2009 recession including significant debt defaults. The financial crisis may eventually worsen, to resemble a collapse situation as described by Joseph Tainter in The Collapse of Complex Societies (1990) or an adverse decline situation similar to adverse scenarios foreseen by Donella Meadows in Limits to Growth (1972).     

Excess false positive rate caused by population stratification and disease rate heterogeneity in case-control association studies

Case-control association studies using unrelated cases and controls may suffer from potential confounding due to population stratification. Bias and variance distortion caused by population stratification in the commonly used allele-based tests can considerably inflate the Type I error rate. It is shown that the bias vanishes in the absence of disease rate heterogeneity. If only population stratification exists, a proper estimate of the variance of the allele-based test statistic is developed. Using this estimated variance yields a valid Type I error. However, when the frequencies of the allele under study and the disease rates differ among the subpopulations, it is difficult to correct for this bias. Explicit expressions for the excess false positive rate (EFPR) of the test due to bias and variance distortion are derived. It turns out that the bias created when both population stratification and disease rate heterogeneity are present usually has a greater effect on the EFPR than variance distortion. Comprehensive simulation studies strongly support these results.     

Moral reasoning, classroom behavior, and sociometric status among elementary school children.

Relations among moral reasoning, classroom behavior, and sociometric status were investigated in a sample of 133 2nd and 3rd graders. It was hypothesized that hedonistic and needs-oriented moral reasoning, 2 forms of L. Kohlberg's (1984) Stage 2 moral reasoning, would be differentially related to teachers' ratings of classroom behavior and to sociometric status. Among boys, hedonistic moral reasoning was associated with the lack of social competencies, acting-out behavior, and low social preference. In addition to influencing sociometric status indirectly through social behavior, moral reasoning was found to explain variance in sociometric status not accounted for by either acting out or social competencies. Results support N. Eisenberg's (1986) claim that hedonistic and needs-oriented reasoning are qualitatively distinct. Although both forms of reasoning characterize Kohlberg's Stage 2, it is hedonistic reasoning, not needs-oriented reasoning, that appears to be associated with poor social behavior and, in turn, low sociometric status. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Structural breakdown of starch-based foods during gastric digestion and its link to glycemic response: In vivo and in vitro considerations

The digestion of starch-based foods in the small intestine as well as factors affecting their digestibility have been previously investigated and reviewed in detail. Starch digestibility has been studied both in vivo and in vitro, with increasing interest in the use of in vitro models. Although previous in vivo studies have indicated the effect of mastication and gastric digestion on the digestibility of solid starch-based foods, the physical breakdown of starch-based foods prior to small intestinal digestion is often less considered. Moreover, gastric digestion has received little attention in the attempt to understand the digestion of solid starch-based foods in the digestive tract. In this review, the physical breakdown of starch-based foods in the mouth and stomach, the quantification of these breakdown processes, and their links to physiological outcomes, such as gastric emptying and glycemic response, are discussed. In addition, the physical breakdown aspects related to gastric digestion that need to be considered when developing in vitro–in vivo correlation in starch digestion studies are discussed. The discussion demonstrates that physical breakdown prior to small intestinal digestion, especially during gastric digestion, should not be neglected in understanding the digestion of solid starch-based foods.