Neuropsychological functioning in posttraumatic stress disorder and alcohol abuse.

Studies have shown differences in neuropsychological functioning between groups with posttraumatic stress disorder (PTSD) and control participants. Because individuals with PTSD often have a history of comorbid alcohol abuse, the extent to which an alcohol confound is responsible for these differences remains a concern. The current study compares neuropsychological testing scores in 4 groups of veterans with and without PTSD (PTSD+ and PTSD-, respectively) and with and without a history of alcohol abuse (ETOH+ and ETOH-, respectively): n for PTSD+/ETOH- = 30, n for PTSD+/ETOH- = 37, n for PTSD-/ETOH+ = 30, and n for PTSD-/ETOH- = 31. Results showed that PTSD, when alcohol, educational level, vocabulary, and depression are controlled for, was associated with decreased verbal memory, attention, and processing speed performance. Alcohol abuse history was associated with decreased visual memory performance. By controlling for alcohol and depression, the authors can more conclusively demonstrate that verbal memory and attention differences are associated with PTSD. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Endocytosis of androgen-binding protein (ABP) by spermatogenic cells

To test whether Sertoli cell-secreted ABP could serve as steroid carrier to the germ cell (GC) lineage, radiolabeled ABP and SHBG and gold SHBG were used for binding studies and for internalization studies based on transmission electron microscope analyses and autoradiography of the radiolabeled samples. The data clearly showed that: (1) rat and human germ cells possess a single class of binding sites for rat ABP and human SHBG respectively (Kd of 0.78 and 0.56 nM); (2) 1.7 x 10(10) and 2.7 x 10(10) sites/mg protein was found in the corresponding plasma membrane preparations; (3) the receptor peak was eluted in the same position as dextran blue: 2000 kDa (M(r) = 2 x 106) for labeled rat ABP; (4) in the whole GC lineage, the labeled ligand was internalized through an endocytic pathway involving clathrin coated structures and the distribution was similar throughout the maturation step, however striking differences in the internalization rate were revealed with regard to the maturation step; and (5) this internalization occurred even in ligated seminiferous tubules, via the Sertoli cells cytoplasm. When isolated rat GC were incubated in the presence of ABP, a dose dependent increase in labeled secreted protein was observed for spermatocytes (50-250%) whereas ABP had no effect on spermatids. Addition of steroids and ABP caused a 200 and 50% increase in labeled secreted proteins for spermatocytes and spermatids respectively. 2-D SDS-PAGE analysis revealed that ABP alone increased the secretion of specific spermatocyte proteins whereas steroids in the presence of ABP resulted in the synthesis of new spermatocyte secreted proteins. Taken together these results strongly suggest that ABP may be required for spermatogenesis either as a steroid transmembrane carrier or on its own.     

Evaluation of grounded isometric interface for whole‐body navigation in virtual environments

Whole‐body interaction is an effective way to promote the level of presence and immersion in virtual reality systems. In this paper, we introduce “G‐Bar,” a grounded isometric interaction device that naturally induces whole‐body interaction without complicated sensing and active haptic feedback apparatus. G‐Bar takes advantage of the significant passive reaction force feedback sensed throughout the body to produce an enhanced level of presence/immersion and possibly even task performance. For detailed investigation in the contributing factors, two experiments were carried out to assess the comparative effectiveness of G‐Bar to the following: (1) grounded but isotonic device (with force feedback and without); and (2) nongrounded handheld devices (both isotonic and isometric). The results showed that the G‐Bar induced significantly higher presence and competitive task performance (fixed velocity navigation) than the isotonic (grounded or handheld) and nongrounded isometric interfaces. Compared with the grounded isometric device with active force feedback, G‐Bar produced competitive performance. In particular, the analysis of the subjective evaluation revealed a high correlation between the level of presence and whole‐body interaction. On the other hand, whole‐body experience was not induced as much with just the active force‐feedback devices. Thus, for appropriate tasks, the grounded isometric interface can be a viable alternative to expensive and mechanically limiting active force‐feedback devices in enhancing user experience. Copyright © 2013 John Wiley & Sons, Ltd.     

Fatigue life prediction under variable loading based on a new damage model

To examine the performance of nonlinear models proposed in the estimation of fatigue damage and fatigue life of components under random loading, a batch of specimens made of 6082 T 6 aluminium alloy has been studied and some of the results are reported in the present paper. The paper describes an algorithm and suggests a fatigue cumulative damage model, especially when random loading is considered. This paper contains the results of mono-axial random load fatigue tests with different mean and amplitude values performed on 6082 T 6 aluminium alloy specimens. Cycles were counted with rainflow algorithm and damage was cumulated with a new model proposed in this paper and with the Palmgren–Miner model. The proposed model has been formulated to take into account the damage evolution at different load levels and it allows the effect of the loading sequence to be included by means of a recurrence formula derived for multilevel loading, considering complex load sequences. It is concluded that a ‘damaged stress interaction damage rule’ proposed here allows a better fatigue damage prediction than the widely used Palmgren–Miner rule, and a formula derived in random fatigue could be used to predict the fatigue damage and fatigue lifetime very easily. The results obtained by the model are compared with the experimental results and those calculated by the most fatigue damage model used in fatigue (Miner’s model). The comparison shows that the proposed model, presents a good estimation of the experimental results. Moreover, the error is minimized in comparison to the Miner’s model.     

Interferometric investigation and simulation of refractive index in glass matrixes containing nanoparticles of varying sizes

The relationship between refractive index and nanoparticle radii of cadmium selenide (CdSe) nanoparticles embedded within glass matrixes was investigated experimentally and by simulations. A homemade automated Michelson interferometer arrangement employing a rotating table and a He-Ne laser source at a wavelength of 632.8 nm determined the refractive index versus nanoparticle radii of embedded cadmium selenide (CdSe) nanoparticles. The refractive index was found to decrease linearly with nanoparticle radius increase. However, one sample showed a step increase in refractive index; on spectroscopic analysis, it was found that its resonant wavelength matched that of the He-Ne source wavelength. The simulations showed that two conditions caused the step increase in refractive index: low plasma frequency and matched sample and source resonances. This simple interferometer setup defines a new method of determining the radii of nanoparticles embedded in substrates and enables refractive index tailoring by modification of exact annealing conditions.