Proteomics of plaques and novel sources of potential biomarkers for atherosclerosis

Cardiovascular disease (CVD) is the leading cause of death and loss of productive life years in the world. The underlying syndrome of CVD, atherosclerosis, is a complex disease process, which involves lipid metabolism, inflammation, innate and adaptive immunity, and many other pathophysiological aspects. Furthermore, CVD is influenced by genetic as well as environmental factors. Early detection of CVD and identification of patients at risk are crucial to reduce the burden of disease and to allow personalized treatment. As established risk factors fail to accurately predict which part of the population is likely to suffer from the disease, novel biomarkers are urgently needed. Proteomics can play a significant role in identifying these biomarkers. In this review, we describe the progress made in proteome profiling of the atherosclerotic plaque and several novel sources of potential biomarkers, including circulating cells and plasma extracellular vesicles. The importance of longitudinal biobanking in biomarker discovery is highlighted and exemplified by several plaque proteins identified in the biobank study Athero-Express. Finally, we discuss the PTMs of proteins that are involved in atherosclerosis, which may become one of the foci in the ongoing quest for biomarkers through proteomics of plaque and other matrices relevant to the progression of atherosclerosis.     

The design of a collision avoidance system for use by Pilots operating on the airport ramp and in taxiway areas

Ground collisions have serious implications from both a safety and a commercial perspective. This paper reports on human computer interaction (HCI) research related to the advancement of a collision avoidance system, for use by Pilots operating on the airport ramp and in taxiway areas. Primarily, this paper focuses on the key findings of this research and the emerging HCI design solution.     

Thin and thick YBCO films grown by MOCVD processes. Study of the angular magnetic field dependence of current transport properties

Thin and thick YBCO Films have been grown by Aerosol Assisted as well as by thermal MOCVD. The Aerosol Assisted MOCVD technique allows the growth of YBCO films from a single liquid source at deposition rates of up to 10m/h.Transport measurements (I-V) on etched microbridges using a single pulse technique have been performed. The angular magnetic field dependence J_c() of the critical current density from T_c down to 50 K has been measured. Transport properties are reported and discussed with respect to the microstructural features as determined by X-ray diffraction and electron microscopy.     

An Experimental Economics Investigation of Shipper-carrier Interactions in the Choice of Mode and Shipment Size in Freight Transport

The paper discusses the theoretical and empirical evidence on the subject and concludes that freight mode choice can be best understood as the outcome of interactions between shippers and carriers, and that mode choice depends to a large extent on the shipment size that results from shipper-carrier interactions. These conclusions are supported by economic experiments designed to test the hypothesis of cooperative behavior. This was accomplished by conducting two sets of experiments (ones with the shipper playing the lead role in selecting the shipment size; and others in which the shipment size decision was left to the carriers), and by comparing their results to the ones obtained numerically under the assumption of perfect cooperation. The comparison of results indicated that the experiments converged to the perfect cooperation case. This is in line with the conclusion from game theory that indicates that under typical market conditions the shipper and carrier would cooperate. These results also imply that it really does not matter who “makes” the decision about the shipment size and mode to be used at a given time period, as over time the shipper—that is the customer—ends up selecting the bids more consistent with its own interest. In other words, these results do not support the assumption that freight mode choice is solely made by the carriers.     

Cobra: a light-weight tool for static and dynamic program analysis

Static source code analysis tools have become indispensable for the development of reliable software applications. The best analyzers can reveal subtle flaws in a code base, but they can also be slow. In part this is due to the collection of detailed information about the possible data and control flow of an application to support the broadest possible range of analyses. For larger code bases it is not unusual that even the best of breed static analyzers can take an hour or more to complete an analysis. In this paper we describe a framework for a much faster, but more light-weight type of static analysis that can support interactive use for standard types of queries. The Cobra tool we designed for this purpose can scale to explore millions of lines of code interactively. The tool is mostly language agnostic, and can therefore easily be configured to resolve even dynamic program analysis queries.     

INTAMAP: The design and implementation of an interoperable automated interpolation web service

INTAMAP is a Web Processing Service for the automatic spatial interpolation of measured point data. Requirements were (i) using open standards for spatial data such as developed in the context of the Open Geospatial Consortium (OGC), (ii) using a suitable environment for statistical modelling and computation, and (iii) producing an integrated, open source solution. The system couples an open-source Web Processing Service (developed by 52°North), accepting data in the form of standardised XML documents (conforming to the OGC Observations and Measurements standard) with a computing back-end realised in the R statistical environment. The probability distribution of interpolation errors is encoded with UncertML, a markup language designed to encode uncertain data. Automatic interpolation needs to be useful for a wide range of applications and the algorithms have been designed to cope with anisotropy, extreme values, and data with known error distributions. Besides a fully automatic mode, the system can be used with different levels of user control over the interpolation process.     

Customising agile methods to software practices at Intel Shannon

Tailoring of methods is commonplace in the vast majority of software development projects and organisations. However, there is not much known about the tailoring and engineering of agile methods, or about how these methods can be used to complement each other. This study investigated tailoring of the agile methods, eXtreme programming (XP) and Scrum, at Intel Shannon, and involved experienced software engineers who continuously monitored and reflected on these methods over a 3-year period. The study shows that agile methods may individually be incomplete in supporting the overall development process, but XP and Scrum complement each other well, with XP providing support for technical aspects and Scrum providing support for project planning and tracking. The principles of XP and Scrum were carefully selected (only six of the 12 XP key practices were implemented, for example) and tailored to suit the needs of the development environment at Intel Shannon. Thus, the study refutes the suggestion that agile methods are not divisible or individually selectable but achieve their benefits through the synergistic combination of individual agile practices; rather, this study shows that an a la carte selection and tailoring of practices can work very well. In the case of Scrum, some local tailoring has led to a very committed usage by developers, in contrast to many development methods whose usage is limited despite being decreed mandatory by management. The agile practices that were applied did lead to significant benefits, including reductions in code defect density by a factor of 7. Projects of 6-month and 1-year duration have been delivered ahead of schedule, which bodes well for future ability to accurately plan development projects.     

Multiaxial fatigue and failure analysis of helical compression springs

Multiaxial fatigue criteria are applied to the analysis of helical compression springs. The critical plane approaches, Fatemi–Socie and Wang–Brown, and the Coffin–Manson method based on shear deformation, were used to predict fatigue lives of the springs under constant amplitude loading. Experimental fatigue lives are compared with the multiaxial fatigue criteria predictions. The stress analysis was carried out in the finite element code ANSYS, and the multiaxial fatigue study was performed using the fatigue software nCode. A failure analysis was conducted in order to determine the fatigue crack initiation point and a comparison of that location with the most damaged zone predicted by the numerical analysis is made. The Fatemi–Socie critical plane approach gives a good prediction of fatigue life. While the Wang–Brown criterion overestimates spring fatigue life, the Coffin–Mason model gives conservative results.     

The Effects of Hippocampal Lesions on Response, Direction, and Place Learning in Rats.

Rats with hippocampal or sham lesions were trained to find food on a T maze located at 2 positions. Response rats were required to make a right or left turn. Direction rats were required to go in a consistent direction (east or west). Place rats were required to go to a consistent location, relative to room cues. One place group had distinguishable start points at the 2 maze positions, whereas another place group had start points facing the same side of the room. Controls took longer to solve a place problem than the response and direction problems when the start points were not distinguishable. Rats with hippocampal lesions were not different than controls on the response problem but were impaired on the direction and place problems. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

How Does Negative Life Change Following Disaster Response Impact Distress Among Red Cross Responders?

The American Red Cross is the largest nongovernmental organization responding to disasters in the United States. This study investigated the impact of negative life change occurring in the year following the September 11, 2001, terrorist attacks on levels of distress among 757 Red Cross Disaster Services Human Resources (national disaster team) employees and volunteers who responded to this disaster. Negative life change in the year following disaster response fully mediated the relationship between disaster response and symptoms of depression and partially mediated the responses between disaster response and posttraumatic stress and anxiety symptoms. Results highlight the importance of life experiences in the year following disaster response and, therefore, the education and follow-up services provided to disaster workers prior to and following disaster assignment. Suggestions for monitoring disaster-related stress during and following assignment are provided. (PsycINFO Database Record (c) 2010 APA, all rights reserved)