Experimentelle und theoretische Untersuchungen von Infrarot reflektierenden Dämmmaterialien

Manche Hersteller von Infrarot reflektierenden Dämmmaterialien werben mit hohen Dämmeigenschaften ihrer Produkte, die angeblich nicht mit Hilfe der klassischen Bauphysik beschrieben werden können. Um deren Dämmqualität zu überprüfen, werden In‐situ‐Messungen durchgeführt. Dazu werden zwei verschiedene Dachaufbauten parallel untersucht: einmal mit Mineralwolle, einmal mit IR‐reflektierender Dämmung. Die Ergebnisse werden mit klassischen Labormessungen verglichen. Die Untersuchungen werden durch Simulationsrechnungen ergänzt. Aus allen Untersuchungen resultiert: die Dachkonstruktion mit der IR‐reflektierenden Dämmung zeigt typische Merkmale eines Aufbaus mit geringerer Dämmwirkung. Außerdem lässt sich das Verhalten des Dachaufbaus mit der IR‐reflektierenden Dämmung während der In‐situ‐Messung sehr gut mit den Ergebnissen aus den klassischen Labormessungen in Übereinstimmung bringen. Experimental and theoretical investigations on infrared reflective insulation. Some manufacturers of IR‐reflective insulation products claim, that their products feature a high insulation quality that cannot be described by traditional methods of building physics. In situ measurements are carried out to verify. Two different roof systems are investigated parallel: one with mineral wool, the other with IR‐reflective insulation. The results of the in situ tests are compared to those of traditional laboratory measurements. Further the examinations are completed by dynamic calculations. As a result it follows from all investigations, that the roof with IR‐reflective insulation shows a typical characteristic of insulation with lower quality. The values of the traditional measurement match with the results of the in situ measurements.     

Photochemische Reaktionen von Pyrazolidon-(3)-betainen. VI. Substituenteneinfluß auf die Photochemische Diaziridinbildung aus Pyrazolidon-(3)-azomethiniminen

Photochemical Reactions of 3-Pyrazolidone Betains. VI. Influence of Substituents on Photochemical Diaziridine Formation from 3-Pyrazolidone Azomethinimines UV-irradiation of 3-pyrazolidone azomethinimines 1a–g in methanol as a solvent produces 40–92% yields of the corresponding 1-(methoxycarbonylethyl)-3-aryl-diaziridines 3a–g . The formation of these products occurs by ring opening of the bicyclic diaziridines 2a–g primarily formed. Although the bicyclic diaziridines 2h and 2i are formed on UV-irradiation in methanol, the betains 1h and 1i do not yield the corresponding diaziridine esters 3 . Kinetical investigations of the acid catalyzed re-formation of the betaines 1a, c, h , and i from the corresponding bicyclic diaziridines show that the basicity of the diaziridine ring in 2 , influenced by substituents in the phenyl ring, is responsible for the re-formation to 1 and the reaction to 3 , respectively. In contrast to the behaviour of the other betains 1 , compound 1j does not react photochemically to yield the bicyclic diaziridine 2j . This shows that an extension of the 4-electron system of the dipolaric azomethinimine group in 1 is necessary for the photochemical cyclization to diaziridines 2 .     

带有转移线圈的改进型缝编织物

介绍了普通缝编设备的改造,即在原有编织功能的基础上,赋予织针的横移运动,因此可在缝编织物中任意加入单层纱线而不受限制.基于此编织原理,采用改进的缝编设备和研制的手动样机成功地进行了试生产,所生产产品与普通缝编织物或其他纺织设备加工的产品相比,具有更好的性能,更适合于制作复合材料.     

Lack of Major Genome-Wide DNA Methylation Changes in Succinate-Treated Human Epithelial Cells

The tricarboxylic acid (TCA) metabolite, succinate, is a competitive inhibitor of dioxygenase enzymes that require alpha ketoglutarate as a cofactor. One family of dioxygenases are the ten-eleven translocation (TET) proteins, which oxidize 5-methylcytosine to promote DNA demethylation. Inhibition of DNA demethylation is expected to lead to DNA hypermethylation, at least at genomic regions at which TET proteins are engaged. We treated human bronchial epithelial cells with succinate for five days and confirmed its effect on TET protein function by observing diminished formation of 5-hydroxymethylcytosine, the first oxidation product of the TET enzymatic reaction. We then analyzed global DNA methylation patterns by performing whole-genome bisulfite sequencing. Unexpectedly, we did not observe differentially methylated regions (DMRs) that reached genome-wide statistical significance. We observed a few regions of clustered DNA hypomethylation, which was also not expected based on the proposed mechanisms. We discuss potential explanations for our observations and the implications of these findings for tumorigenesis.