PPG在上海举办紧固件电泳漆推介会

<正>最近,PPG工业涂料事业部在上海成功举办了紧固件电泳漆推介会,向来自国内外知名汽车制造企业嘉宾和媒体代表介绍了PPG业内领先的电泳漆及其在紧固件涂装领域的优势。紧固件是PPG近年重点关注的市场之一,PPG中国区工业涂料总经理蒋永辉表示,我们希望通过举办这种面对面的交流、互动活动,让更多的企业了解我们产     

中海油采用杜邦液相加氢技术实现超低能耗生产国六柴油

<正>最近,杜邦清洁技术公司很高兴地宣布,中海油惠州石化成功实现了其340万t/a IsoTherming柴油液相加氢装置的工业化应用。2018年9月,中海油以100%负荷完成了IsoTherming柴油液相加氢装置性能考核,装置满足所有设计要求和产品质量目标。中海油惠州另一套260万t/a蜡油液相加氢装置也     

索尔维推出可持续防腐蚀Halar ECTFE水性涂料

<正>索尔维最近宣布,其新型水性涂料系列Halar ECTFE材料进一步提升了金属防腐蚀在化工行业中的应用。这一涂料系列由高黏结性的底漆和面漆组成,用标准的液体喷涂设备即可涂装,施工十分方便。索尔维的Halar ECTFE粉末涂料已用于防腐超过40年,适用于制酸、采矿、纸浆与造纸、制药、食品饮料、半导体等众多行业设备。新推出的水性Halar ECTFE液体涂料技术则将终端应用拓展到了原来粉末涂料无法或者难以涂装的地方,包括形状复杂的结     

巴斯夫多项本土研发的创新产品助力可持续发展

<正>2019年3月12日,巴斯夫在其上海创新园建设全新研发设施,提升在亚太区的创新能力,以进一步加强与汽车行业的合作,并为化工行业提供新型工艺催化剂。新设施包括亚太区汽车应用研发中心和工艺催化研发中心,总共投资近3 400万欧元,占地面积5000 m~2。在开幕仪式上,巴斯夫还展示了一系列本地研发的创新产品,为汽车、建筑和消费品等行业     

亨斯迈携五大创新产品高调亮相2019中国国际染料工业及有机原料、纺织化学品展览会

<正>4月10—12日,2019中国国际染料工业及有机原料、纺织化学品展览会在上海世博展览馆举行。一家致力于提供创新技术和可持续发展的染料、化学助剂及印花墨水的全球领先者——亨斯迈纺织染化事业部展出了染料、化学助剂、印花墨水等方面的领先技术和创新产品,其技术和产品适用于各种纤维及其混纺织物。亨斯迈纺织染化事业部总裁Rohit Aggarwal先生表示:我们     

佐敦工业保护涂料入驻摩贝品牌馆开启电商新渠道

<正>最近,佐敦工业保护涂料与全球领先的化学品电商综合服务平台——摩贝(MOLBASE.CN)达成合作协议,佐敦工业保护涂料摩贝官方旗舰店正式开业,并率先上线了专为零售行业客户量身打造的Easy Pro系列产品。此次合作,是双方通过数字化手段推动渠道多元化发展的积极尝试,以创新的服务模式为行业客户提供更便捷、更高效的采购流程以及焕然一新的采     

伊士曼庆祝Crystex不溶性硫黄品牌成立75周年

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Correction to: Herd concentration areas create greenhouse gas hotspots

Nutrient Cycling in Agroecosystems -     

An esterification protocol for cis-parinaric acid-determined lipid peroxidation in immune cells1,2

Loss of fluorescence from cis-parinaric acid (cPnA) is a sensitive indicator of lipid peroxidation. The purpose of this study was to utilize cPnA to determine, at the level of the intact immune cell, whether enrichment of membranes with polyunsaturated fatty acids (PUFA) increased lipid peroxidation. P388D1 macrophages were labeled by addition of cPnA as an ethanolic solution. Within two minutes of addition, in the absence of serum, cPnA rapidly intercalated into the plasma membrane. Lipid peroxidation was initiated by addition of Fe²⁺-EDTA resulting in a dose-dependent decrease in fluorescence with increased oxidant concentration. Cells previously enriched with PUFA and labeled by intercalation showed no differences in spontaneous or Fe²⁺-induced lipid peroxidation. In separate experiments, 20 μM cPnA in ethanolic solution was injected into cell culture media containing 0.1% essentially fatty acid free bovine serum albumin (BSA). Cells were resuspended and incubated for 90 min at 37°C. After washing with BSA to remove cPnA which had not incorporated, 0.5% (0.1 μM) of the added cPnA was found esterified within cellular lipids. This level of cPnA provided a 100-fold increase over basal autofluorescence levels. Cells labeled in this manner also lost fluorescence in a dose-dependent manner as levels of oxidant stress increased. Cells enriched with PUFA and labeled by esterification had significantly increased rates and total amounts of lipid peroxidation. Co-incubation with α-tocopherol and PUFA resulted in a decrease in lipid peroxidation which was not significantly different from control cells. In conclusion, esterification of cPnA into membrane phospholipids can sensitively detect changes in lipid peroxidation induced by alteration of membrane PUFA and/or vitamin E content. Presented in part at the Experimental Biology Meetings, Anaheim, California, April 1994. Contribution from the Missouri Agriculture Extention Station, Journal #12,495.     

A New Potent and Selective Monoamine Oxidase-B Inhibitor with Extended Conjugation in a Chalcone Framework: 1-[4-(Morpholin-4-yl)phenyl]-5-phenylpenta-2,4-dien-1-one

The general blueprint for the design of monoamine oxidase-B (MAO-B) inhibitors has been based on two phenyl or heteronuclei linked via a spacer of appropriate length. In this study, 1-[4-(morpholin-4-yl)phenyl]-5-phenylpenta-2,4-dien-1-one (MO10) was prepared by the condensation of 4′-morpholinoacetophenone and cinnamaldehyde in basic alcoholic medium. MO10 was assessed for inhibitory activity against two human MAO isoforms, MAO-A and MAO-B. Interestingly, MO10 showed a remarkable inhibition against MAO-B with an IC₅₀ value of 0.044 μM along with a selectivity index of 366.13. The IC₅₀ value was better than that of lazabemide (IC₅₀ value of 0.063 μM), which was used as a reference. Kinetics studies revealed that MO10 acted as a competitive inhibitor of MAO-B, with a K_i value of 0.0080 μM. The observation of recovery of MAO-B inhibition, compared to reference levels showed MO10 to be a reversible inhibitor. MTT assays showed that MO10 was nontoxic to normal VERO cells with an IC₅₀ value of 195.44 μg/mL. SwissADME predicted that MO10 provided advantageous pharmacokinetics profiles for developing agents acting on the central nervous system, that is, high passive human gastrointestinal absorption and blood–brain barrier permeability. Molecular docking simulations showed that MO10 properly entered the aromatic cage formed by Y435, Y398, and FAD of the active site of MAO-B. On the basis of these results, MO10 can be considered a promising starting compound in development of agents for the treatment of various neurodegenerative disorders.