Unveiling the Effects of In Situ Layer–Layer Interfacial Reaction in Multilayer Polymer Films via Multilayered Assembly: From Microlayers to Nanolayers

Multilayered polymer films are increasingly used in the daily life, but their macroscopic properties are always limited by the layer–layer interfacial compatibility. In this work, the influence of interface modification through in situ layer–layer interfacial reaction during a multilayered assembly is revealed from micro‐ to nanolayer films, based on maleated poly(vinylidene fluoride) and polyamide‐6. In the presence of interfacial reaction and confinement, layer architecture and microstructure are highly dependent on the number of layers. Specifically, for nanolayer films having smaller layer thicknesses and higher reaction extent, layer integrity is reduced with the occurrence of interfacial instabilities. Depending on the microstructural evolution from multilayer assembly, those films exhibit quantitatively different extensional rheological and dielectric properties from micro‐ to nanolayers. More importantly, dielectric spectroscopy reveals the contribution of copolymer‐rich interphases to the dielectric performance of micro/nanolayered films. Additionally, charge transport dynamics in nanolayered films also differ significantly from their microlayered counterparts. They are attributed to the strong dependence of interfacial reaction extent and resulting microstructure on the number of layers and layer thicknesses. This work clearly illustrates how the control of layer–layer interfacial reaction in micro/nanolayer assembly can tune the interfacial, microstructure, and macroscopic properties of multilayered products.     

The effect of resultant force at the pushrim on shoulder kinetics during manual wheelchair propulsion: a simulation study

The aim of this study was to determine, by simulation on real data, the effect of modifying the direction or effectiveness of a given force amplitude on the load sustained by the shoulder estimated by joint forces and moments. Kinematics and kinetics data were recorded on 14 manual wheelchair users 68.2+/-5.2 years for 10 s at sub-maximal speed (0.96-1.01 m/s). The simulation consisted in modifying force effectiveness at the pushrim while maintaining the same initial force amplitude. Shoulder kinetics were computed for simulated resultant forces from radial to tangent directions and also for initial force effectiveness. The results show that as the force was simulated tangent to the wheel, there was a significant increase in the average proximal and anterior shoulder joint forces. Also, significant increases in average internal rotation, flexion in the sagittal and horizontal plane moments were reported. Higher shoulder kinetics could accelerate the onset of fatigue and increase the risk of injury. A single-case analysis revealed an improvement window for force effectiveness ( approximately 10%) in which shoulder kinetics were not substantially increased. Our results provide useful information on what would happen to shoulder kinetics if we were able to teach manual wheelchair users to modify their force pattern at the pushrim. The results suggest that for an elderly population, it is not wise to aim at producing a mechanically optimal resultant force at the pushrim (i.e., tangent). Smaller increases of the initial force effectiveness would be preferable.     

TRPM8 as an Anti–Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination

In the fight against prostate cancer (PCa), TRPM8 is one of the most promising clinical targets. Indeed, several studies have highlighted that TRPM8 involvement is key in PCa progression because of its impact on cell proliferation, viability, and migration. However, data from the literature are somewhat contradictory regarding the precise role of TRPM8 in prostatic carcinogenesis and are mostly based on in vitro studies. The purpose of this study was to clarify the role played by TRPM8 in PCa progression. We used a prostate orthotopic xenograft mouse model to show that TRPM8 overexpression dramatically limited tumor growth and metastasis dissemination in vivo. Mechanistically, our in vitro data revealed that TRPM8 inhibited tumor growth by affecting the cell proliferation and clonogenic properties of PCa cells. Moreover, TRPM8 impacted metastatic dissemination mainly by impairing cytoskeleton dynamics and focal adhesion formation through the inhibition of the Cdc42, Rac1, ERK, and FAK pathways. Lastly, we proved the in vivo efficiency of a new tool based on lipid nanocapsules containing WS12 in limiting the TRPM8–positive cells’ dissemination at metastatic sites. Our work strongly supports the protective role of TRPM8 on PCa progression, providing new insights into the potential application of TRPM8 as a therapeutic target in PCa treatment.     

Does Blood Pressure Control by Gentle Ultrafiltration Improve Survival in Hemodialysis Patients?

Agentle ultrafiltration can be achieved using a long and slow hemodialysis. It is easier to achieve gentle ultrafiltration if the interdialytic weight intake is moderate ( i.e., if the patient maintains a low sodium diet) and if diffusion allows for a negative or nil sodium balance during the session ( i.e., dialysate sodium < 140 mmol/L). A gentle ultrafiltration allows control of blood pressure by reducing the extracellular volume to its ideal level, the “dry weight,” at the end of the session. Controlling blood pressure reduces cardiovascular mortality, which is by far the foremost cause of death in hemodialysis. Controlling blood pressure means reducing the occurrence of both hypertension and hypotension. Hypotension has been reported to correlate with mortality in hemodialysis as much as or more than hypertension itself. This “U‐curve” phenomenon is not paradoxical. It displays two distinct facts on the same figure: an increased early mortality in hypotensive patients (hypotension is a marker of frailty or congestive heart failure, both of which cause increased mortality) and, on the other hand, the well‐established, long‐term increased mortality in hypertensive patients. Hypotension is not a mandate to undertreat hypertension.     

Particle size characterisation of in-flow milling products by video image analysis using global features

The objective of this work was to characterise the particle size of milling products by image analysis. Four classes of milling products were obtained by varying the roll gap of the second break roll of the mill. Images were acquired by using an in-flow imaging system implemented in the mill, and 1300 images were recorded for each class. Three methods of image analysis were investigated: morphological opening, constant grey level run lengths and grey level spatial interdependences. Discriminant analyses were applied to the data extracted from the images by the three methods in order to identify each class of milling product. More than 77% of the samples were correctly assigned to their group, both for the calibration and validation sets. The best results were obtained by applying morphological openings or by computing parameters from the co-occurrence matrices. The number of correct classifications rose to 81% of samples with only three variables selected for the opening curves and to 83% with three co-occurrence parameters. © 1998 Society of Chemical Industry     

Improving realism of a surgery simulator: linear anisotropic elasticity,complex interactions and force extrapolation

In this article, we describe the latest developments of the minimally invasive hepatic surgery simulator prototype developed at INRIA. The goal of this simulator is to provide a realistic training test bed to perform laparoscopic procedures. Therefore, its main functionality is to simulate the action of virtual laparoscopic surgical instruments for deforming and cutting tridimensional anatomical models. Throughout this paper, we present the general features of this simulator including the implementation of several biomechanical models and the integration of two force‐feedback devices in the simulation platform. More precisely, we describe three new important developments that improve the overall realism of our simulator. First, we have developed biomechanical models, based on linear elasticity and finite element theory, that include the notion of anisotropic deformation. Indeed, we have generalized the linear elastic behaviour of anatomical models to ‘transversally isotropic’ materials, i.e. materials having a different behaviour in a given direction. We have also added to the volumetric model an external elastic membrane representing the ‘liver capsule’, a rather stiff skin surrounding the liver, which creates a kind of ‘surface anisotropy’. Second, we have developed new contact models between surgical instruments and soft tissue models. For instance, after detecting a contact with an instrument, we define specific boundary constraints on deformable models to represent various forms of interactions with a surgical tool, such as sliding, gripping, cutting or burning. In addition, we compute the reaction forces that should be felt by the user manipulating the force‐feedback devices. The last improvement is related to the problem of haptic rendering. Currently, we are able to achieve a simulation frequency of 25 Hz (visual real time) with anatomical models of complex geometry and behaviour. But to achieve a good haptic feedback requires a frequency update of applied forces typically above 300 Hz (haptic real time). Thus, we propose a force extrapolation algorithm in order to reach haptic real time. Copyright © 2002 John Wiley & Sons, Ltd.     

Parallel object monitors

Coordination of parallel activities on a shared memory machine is a crucial issue for modern software, even more with the advent of multi‐core processors. Unfortunately, traditional concurrency abstractions force programmers to tangle the application logic with the synchronization concern, thereby compromising understandability and reuse, and fall short when fine‐grained and expressive strategies are needed. This paper presents a new concurrency abstraction called POM, parallel object monitor, supporting expressive means for coordination of parallel activities over one or more objects, while allowing a clean separation of the coordination concern from application code. Expressive and reusable strategies for concurrency control can be designed, thanks to a full access to the queue of pending requests, parallel execution of dispatched requests together with after‐actions, and complete control over reentrancy. A small domain‐specific aspect language is provided to adequately configure pre‐packaged, off‐the‐shelf synchronizations. Copyright © 2007 John Wiley & Sons, Ltd.     

基于最小能量法的无线传感器网络节点能量有效性研究

分析了传统无线网络系统模型中的能耗.利用最小能量编码（ME-Coding）作为信源编码的On/Off Keying(OOK)调制方法,对节点间传输的信号序列进行了优化,结果提高了信噪比,降低了误码率.但实验模拟仿真结果表明,当将链路能耗考虑进总体能量消耗中后,若使用传统系统模型,其总能耗并未得到优化. 因此提出并验证了更加适合最小能量法的系统模型,以便降低系统能耗和延长传感器网络节点的寿命.