Effects of dextran, gelatine and homologous plasma on circulation in shock caused by severe anemia in the dog

Irreversible shock is produced in 28 anaesthetized mongrel dogs by withdrawal of erythrocytes and substitution by dextran, gelatine or plasma to an average Hb of 4.5g%. In contrast to other shock models cardiac output and perfusion pressure are not decreased by this preparation. In order to maintain arterial blood pressue above 90 mm Hg significantly more gelatine than dextran or serum has to be infused. There is no difference in hemodynamic responses after treatment with dextran or gelatine respectively. Both groups treated with colloidal solutions have the same survival rate of 38%. In the serum substituted dogs, however,survival rate is significantly greater (83%). Very likely this is due to a greater buffer capacity preventing severe acidosis, which is observed in the animals treated with colloidal solutions.     

Evaluation of Stabilisers for Peroxide Bleaching

A composite experimental design has been used to investigate the effect of stabiliser concentration, alkali concentration and treatment time on the reflectance (whiteness) and fluidity of hydrogen peroxide bleached cotton fabric. Four stabilisers were investigated under short and long dwell steaming conditions. The results show that this experimental method is well suited to the comparison of stabilisers for peroxide bleaching. The work shows that the conditions required to provide optimum whiteness with low chemical damage vary considerably from stabiliser to stabiliser and from system to system.     

Evaluation of nefazodone as a serotonin uptake inhibitor and a serotonin antagonist in vivo

Nefazodone (2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one) has been reported to be effective in the treatment of depression. Antagonism of serotonin type 2A (5HT2A) receptors, as well as inhibition of the serotonin (5HT) uptake carrier, has been suggested to contribute to the antidepressant action of nefazodone in vivo (Eison et al., 1990). Nefazodone weakly antagonized the quipazine-induced rise in rat serum corticosterone levels and the quipazine-induced increase in rat hypothalamic 3-methoxy-4-hydroxy-phenylglycol sulfate, suggesting blockade of 5HT2A receptors in vivo. Nefazodone, however, failed to antagonize the p-chloroamphetamine-induced depletion of mouse or rat brain 5HT, displaying a lack of effect on the 5HT uptake carrier. These data extend previous in vitro and in vivo data (Eison, et al. 1990) reporting nefazodone to be an antagonist at 5HT2A receptors, but fail to show inhibition of the 5HT uptake carrier in the same dose range.     

A computer-controlled spraying-freezing apparatus for millisecond time-resolution electron cryomicroscopy

The application of gene therapy techniques to the clinical problem of coronary restenosis has generated tremendous attention and enthusiasm. Use of gene transfer technology to prevent a common intractable illness would represent a watershed event for human gene therapy. However, the time is not yet right to initiate gene therapy trials for restenosis. The biology of restenosis is incompletely understood, catheter-based gene delivery is poorly adapted to the coronary circulation, and current gene transfer vectors are ill-suited for safe and effective gene delivery to the coronary artery wall. Basic research designed to overcome these obstacles is currently more appropriate than the initiation of clinical trials.     

Bimetallic Pt-Metal catalysts for the decomposition of methanol: Effect of secondary metal on the oxidation state, activity, and selectivity of Pt

We present here a study of methanol (MeOH) decomposition over a series of bimetallic Pt-M catalysts, with M = Au, Pd, Ru, Fe. All samples have the same initial size distribution (3 nm nanoparticle height), support (ZrO₂), and preparation conditions. Therefore, differences in the electronic and catalytic properties of the samples tested are related directly to the addition of the secondary metals (M). We find that the oxidation state as well as the activity of Pt is heavily influenced by the addition of the secondary metal. PtO is found to be highly stable in these systems and increasing concentrations of metallic Pt are associated with the surface segregation of metal M due to its affinity for the oxygen present during air annealing.     

Exposure assessment of carcass disposal options in the event of a notifiable exotic animal disease: application to avian influenza virus

We present a generalized exposure assessment of 28 disposal options for poultry carcasses in the event of a highly pathogenic avian influenza (HPAI) outbreak. The analysis supports a hereto unverified disposal hierarchy for animal carcasses, placing waste processing (e.g., incineration and rendering) above controlled disposal (e.g., landfill), above uncontrolled disposal (e.g., burial on-farm). We illustrate that early stages of the disposal chain (on-farm) pose greater opportunities for exposure to hazardous agents than later stages, where agents are generally contained, wastes are treated, and residues are managed by regulated processes. In selecting carcass disposal options, practitioners are advised to consider the full range of hazards rather than focusing solely on the HPAI agent, and to give preference to technologies that (i) offer high destruction efficiencies for target pathogens; (ii) do not give rise to significant releases of other pathogenic organisms; and (iii) do not release unacceptable concentrations of toxic chemicals. The approach offers an exposure assessment perspective for carcass disposal, thus providing a risk-informed basis for contingency planning and operational intervention. The authors recognize that relevant legislation, public perception, available capacity, and cost also need to be considered when selecting disposal options in the event of HPAI.     

扔掉眼镜吧!——裸眼3D技术略览

喜欢欣赏3D大片的你,有否觉得沉重的3D眼镜让你鼻梁倍感压力？有否觉得3D眼镜束缚了你的视野？连2012广州海心沙跨年盛典都采用裸眼3D舞台了,你还固执地坚持一定要带上眼镜看3D吗？扔掉眼镜,一同感受裸眼3D的魅力吧!     

将电影下载到平板电脑TF卡中

当前主流安卓平板电脑存储容量依旧以8GB为主,除掉系统和必要软件占用空间后,消费者实际能使用的存储空间在5GB左右,用于安装软件足矣,不过对于电影、电视剧迷来说,5GB空间远远不够。于是,